Encouraging news from #covaxin Phase 3, 1st interim analysis:

✅ Estimated efficacy of 80.6%.

Efficacy based on first 43 cases amongst the 25.8k trial participants. 36/43 in placebo group and 7 in vaccine group = 80.6% estimated efficacy.

1/3
Note that as per initial P3 trial design, 130 +ve cases is the target to analyze final P3 efficacy. Interim efficacy was to be analysed at 43 and 87 cases. So, be aware that this is the first milestone (43 cases) and efficacy can change over the course of trial.

2/3
We will have to see the detailed paper on these results to flag any exclusions etc.

Nevertheless, this should bolster public confidence, especially at a time when larger groups are being vaccinated.

3/3
Post note: The critical discussions around #covaxin have been around the 'process' leading to it's approval, rather than the vaccine itself. Discussions triggered by the new efficacy data, should differentiate between questions on process vs. questions on vaccine.

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More from @covid19indiaorg

3 Mar
A wonderful compilation of vaccination experience shared by our readers across different cities.

It's a diverse set - some fully through Co-WIN, some walk-in, some Co-WIN + walk in etc.
Different locations have different ways of making it work.

Catch the thread below 👇

1/n
Bengaluru:
My mother was the 1st person to be vaccinated in KA. We registered sharp at 9AM got the appointment and went and got vaccinated at 12 noon after inauguration. It's important to repeatedly try as server is loaded some of my relatives got appt after multiple tries.

2/n
Faridabad, Haryana:
Yes parents did it today at a private hospital. It was walk-in and took less than 30mins, was seamless process very well managed.

3/n
Read 13 tweets
1 Mar
Experience of a volunteer in our team who was able to book vaccination appointment on cowin.gov.in today:

➡️ Accessed the website few minutes past 9am. Entered mobile number to receive OTP.
➡️ Initially there was a delay in receiving the OTP.

1/n
➡️ The website took quite a while to move from the first screen to the next where OTP could be entered.
➡️ Received the OTP after a wait of 5 to 10 minutes. This looked to be an initial issue. Subsequent requests for OTP happened without delays.

2/n
➡️ Was presented with a screen to enter details of vaccine beneficiary. The data entry was straightforward with ID card type, number, name gender and year of birth required to be entered.
➡️ After doing the registration, there was option to enter additional beneficiaries.

3/n
Read 12 tweets
27 Feb
Initial guidelines on next phase of vaccination starting on 1st March.
Important read.

✅ Eligible groups: (a) All citizens above 60 yrs. of age. (b) Those between 45 to 59 yrs of age, but with SPECIFIC COMORBIDITIES.

✅ Empanelled private sector hospitals to be included.

1/n
✅ 3 Modes of registration:
➡️ Advance Self Registration: Prior registration using CoWIN 2.0 app (yet to be available for public?).
➡️ On-site Registration: Walk-in registration at vaccination centers.
➡️ Facilitated Cohort Registration: Specific groups mobilized by...

2/n
the state and brought to the vaccination centers.

✅ All beneficiaries, irrespective of mode of registration to carry one photo id card as per acceptable list of documents.

✅ Free at Govt. Centers.
Pvt. Centers can charge upto INR 250/dose.

3/n
Read 4 tweets
22 Feb
With news of Dr. Reddy's applying for accelerated approval of 'Sputnik V' vaccine, here is a quick summary of the potential candidate:

✅ Vaccine platform: Viral vector technology using Adenovirus as the vector. Covishield uses the same platform, but there is a difference.

1/n
✅ Sputnik V uses 2 different variants of the human adenovirus for the 1st and 2nd dose, unlike Covishield where both doses use the same variant of a chimpanzee adenovirus.

✅ Who is developing this vaccine? Gamaleya Research Institute, Russia.

2/n
✅ Has the vaccine got approval in other countries? Russia stirred critical discussions when use of Sputnik V was authorized in Russia before completion of trials. Subsequently Phase 3 interim results have been published.
20+ countries have given emergency approval.

3/n
Read 9 tweets
21 Feb
In an earlier analysis, we had seen how the TPR and CPM of Kerala, spiked post September, 2020.

Results of the 3 national sero surveys give clues to interpret this.

➡️ As of August 2020, KL had a seroprevalence of only 0.8% compared to national avg. of 6.6%.

1/5
➡️ This relatively low prevalence in KL correlates with the lower case load seen in the state till August.

➡️ In Dec, the prevalence saw a multi fold increase to 11.6% (national 21%) from 0.8% in August. This is reflected in the significant spike seen in KL from September.

2/5
➡️ It is notable that in Aug, KL had a relatively low prevalence of 0.8% - reflecting the initial control of spread.
➡️ It left a high % of population vulnerable to infection, which would have contributed to the spike post August. Furthered by local body elections and Onam.

3/5
Read 5 tweets
20 Feb
How has Covid19 and the changes brought by it, affected different spheres of your life?
Let us know in this series of polls:

1. What impact did Covid19 have on your job and career prospects?

1/7
2. How did Covid19 affect your personal relationships with your dearest ones?

2/7
3. How did Covid19 affect your physical health?

3/7
Read 7 tweets

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