Liz Szabo Profile picture
5 Mar, 18 tweets, 7 min read
LIVE @NC4HR: Dr. Paul G. Auwaerter of @JohnsHopkinsDOM notes that people infected with B.1.1.7 variant are infectious longer -- eight days instead of five days.
LIVE @NC4HR: Dr. Paul G. Auwaerter of @JohnsHopkinsDOM notes effectiveness of mRNA vaccines in Israel as good as in clinical trials.
Good protection in people over 70, who normally don't do as well with vaccines. Image
LIVE @NC4HR: Dr. Paul G. Auwaerter notes Houston has four variants circulating in the city.
LIVE @NC4HR: Keeping viral transmission low is the best way to prevent more variants, says Dr. Paul G. Auwaerter. That includes social distancing, masks, vaccination. Image
LIVE @NC4HR: Stuart C. Ray, MD notes that a year ago, everyone assumed coronavirus wouldn't mutate much, that it mutates 5x less than flu. But the spread has been so enormous that coronavirus has had lots of chances to mutate.
LIVE @NC4HR: Stuart C. Ray says coronavirus mutating at rate of 22 mutations per year. In contrast, flu mutates 5x as fast.
LIVE @NC4HR: Stuart C. Ray explains how variants develop. If a person stays infected for weeks b/c of weak immune system, the virus has more chance to mutate. Exposure to convalescent plasma/monoclonal antibodies can pressure virus to adapt.
Why are so many variants all of a sudden? Is coronavirus evolution going faster? Stuart Ray says variants are in the fast lane, moving faster.
LIVE @NC4HR
Dr. Stuart Ray on variants. "A little bit of speeding up might be expected, but this is a significant jump."
If infected people die, the virus doesn't mutate and spread. If infected ppl survive long w/ infection, that gives virus time to mutate. Image
LIVE @NC4HR
Dr. Stuart Ray on variants:
"Convalescent plasma and other selective pressures may be driving evolution" of variants.
LIVE @NC4HR
Dr. Stuart Ray on variants: Why is B.1.1.7 more lethal?

"The number of people infected is the real driver of death. More people will die b/c more people will be infected."
LIVE @NC4HR
Dr. Stuart Ray on variants: Picture a smoker with a cloud of smoke around their head. Someone near them is going to inhale more smoke. A person with a coronavirus variant has a bigger cloud of viruses around them, so people near them more likely to be infected.
LIVE @NC4HR
Dr. Stuart Ray: Some infections could be deep in lungs, which aren't detected on a nasopharyngeal swab.
LIVE @NC4HR:
Paul G. Auwaerter says we may need to change isolation/quarantine rules if variants become dominant/ bc ppl shed infectious varraint virus longer.

For this reason, Dr. Stuart Ray says people need to wear masks as they recover.
LIVE @NC4HR: Dr. Stuart Ray: "Getting a vaccine is not a 'go to the gym free card' or 'go out to bars free card." Given the uncertainty about variants, says we need to be extra cautious. We don't know how variants will spread, be affected by vaccine.
LIVE @NC4HR: Dr. Stuart Ray: If one cell is infected with two different variants, they can shuffle genomes and recombine to create a new, monster variant, with mutations from both and totally new characteristics.
LIVE @NC4HR: Paul G. Auwaerter says we're not likely to vaccinate enough Americans to eradicate coronavirus, which is likely to stick around for years.

Dr. Stuart Ray says tracking deaths doesn't capture the full extent of harm, given the huge number of long haulers.
Black and Hispanic Americans explain why they got vaccinated, in spite of high rates of vaccine hesitancy in their communities.
cnn.com/2021/03/05/us/…

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More from @LizSzabo

3 Mar
This slide includes data that could be used to argue both for/against giving everyone one dose before giving people a second.
Here's another slide contrasting the arguments for/against giving everyone one dose before anyone gets the second. One major point: The one-dose strategy would violate the FDA's emergency use authorization.
CDC advisory panel yesterday also debated whether people who've had covid need 2 shots or 1. Once again, giving only one shot would violate the FDA's emergency authorization.
Read 16 tweets
1 Mar
An advisory committee to the CDC is meeting as we speak. You can watch here: #acip ustream.tv/channel/VWBXKB…
@InfectiousPS said she's gotten 80% of her staff vaccinated, with 10% waiting to see how others do. Dr. Tom Shimabakuru is speaking now about safety monitoring. Here's his presentation. #acip
cdc.gov/vaccines/acip/…
Who serves on the CDC vaccine advisory group? Here's the list: #ACIP cdc.gov/vaccines/acip/…
Read 27 tweets
17 Feb
@WHCOVIDResponse is holding another live briefing. I'll be live tweeting. @KHNews
Live @JeffZients: 13.5 million doses going out this week. On track to have vaccines for 300 million Americans by July. 700 federal personnel to be vaccinators. 1000 members of military will support community vaccination sites.
Live @JeffZients: Covid vaccines will be available at community centers, high school gyms, churches, stadiums, pharmacies.
Read 30 tweets
11 Feb
LIVE @DrPaulOffit: Good news. No difference in rates of Bell's palsy between vaccinated people and non-vaccinated.

Some ppl have developed bleeding issues a day after vaccine, but that's "too soon" for the vaccine to have caused the bleeding.
I'm live tweeting another great interview w/ Dr. Howard Bauchner. He notes that we have 6 months now of vaccine data, since first large study began. No serious safety issues. He said he's reassured.
LIVE: "Here's when to worry" about covid variants eluding vaccines, @drpauloffit says, when people who were vaccinated gets covid again and is hospitalized."
Read 27 tweets
27 Jan
LIVE @DrNunezSmith: "We're removing all out-of-pocket costs for these vaccines."
LIVE @DrNunezSmith said people need paid time off to go get the vaccine.
LIVE @DrNunezSmith: Biden team is launching a public relations campaign so everyone can learn facts about vaccines.
Read 16 tweets
27 Jan
FAUCI LIVE is updating us on therapeutics. Dexamethasone reduces mortality late in the disease. Remdesivir works earlier in the disease, as well as some monoclonal antibodies and convalescent plasma.
FAUCI LIVE: Here are the vaccines in development.
FAUCI LIVE: Covid variants are more infectious and possibly more deadly. B.1.1.7, the UK variant, has a "very slight if at all" vaccine-induced antibodies. "Things get a bit more problematic" for the South African variant.
Read 6 tweets

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