Share this page!

Mac n’ Chise 🧬🦠🧫 Profile picture
Twitter logo
7 Mar, 5 tweets, 2 min read
I figured it was important to highlight this, especially when you might see fear-inducing headlines about this variant spreading quickly. B.1.1.7 now accounts for 20% of our cases in the U.S., HOWEVER we are seeing our lowest case counts now since October.
nytimes.com/interactive/20…
Even in states with low-restrictions we’re not seeing a resurgence in overall infections. While we are not fully in the clear yet, a combination of increased vaccinations, higher levels of natural immunity, and other mitigation efforts will help us avoid sharp spikes in cases.
Yesterday, the U.S. set a record of 2.9M vaccines administered, getting closer to the goal of 3M+ administered daily. This is the opportune time to gain an advantage with mass vaccination efforts as vaccine supply increases.
And clearly we can see here for other areas, despite B.1.1.7 spreading the overall case count is decreasing.
As I stated before, this works to our advantage as we witness this selective pressure. B.1.1.7 may essentially allow us time to administer booster vaccinations against this variant and it’s added E484K. We know our vaccines are effective and boosters for B.1.351 are on their way.

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Mac n’ Chise 🧬🦠🧫

Mac n’ Chise 🧬🦠🧫 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @sailorrooscout

Mac n’ Chise 🧬🦠🧫 Profile picture
9 Mar
How long does natural immunity last? Vaccine-induced? Let’s talk about the importance of cell-mediated immunity. A novel study reveals robust and functional SARS-CoV-2-specific T-cell responses are still retained at 6 months following infection. 🧵
rdcu.be/cgobr
The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predis- pose some to reinfection. We are aware antibody levels decline after clearance of primary infection and there is currently considerable interest in the
relative maintenance of humoral responses over the longer term. Although initial analyses had shown loss of detectable virus-specific antibodies in a proportion of individuals, from what researchers have seen, antibodies can be detected for at least 6-7 months in most people.
Read 14 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
8 Mar
Look at those antibodies!
The latest from the New England Journal of Medicine shows the effective neutralization assessed with serum from participants vaccinated with 2 doses of Pfizer’s BNT162b2 COVID-19 vaccine against VOCs B.1.1.7, B.1.351, and P.1.
nejm.org/doi/full/10.10…
To analyze effects on neutralization elicited by Pfizer’s vaccine, researchers engineered spike mutations from the from the current VOC lineages. They then performed 50% plaque reduction neutralization testing (PRNT50) using 20 serum samples that had been obtained from
15 participants in the pivotal trial 2 or 4 weeks after the administration of the second dose of 30 μg of Pfizer’s vaccine (which occurred 3 weeks after the first immunization). All the serum samples efficiently neutralized their isolate and all the viruses with variant spikes.
Read 6 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
8 Mar
The CDC says fully vaccinated people do not need masks or social distancing when meeting indoors with those at low risk for COVID-19. The rest of the guidelines are as follows. 🧵
The CDC defines people who are fully vaccinated as those who are two weeks past their second dose of the Moderna and Pfizer Covid-19 vaccine or two weeks past a single dose of the Johnson & Johnson vaccine.
The CDC says fully vaccinated people can:
-Visit other vaccinated people indoors without masks or physical distancing

-Visit indoors with unvaccinated people from a single family without masks or physical distancing, if the unvaccinated people are at low risk for severe disease.
Read 13 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
8 Mar
Remember weeks ago when I spoke about variants, selective pressure, and convergent evolution? The emerging variants we see all seem to adapt the E484K escape mutation. What does this mean? It means SARS-CoV-2 might have just played its best card and its reaching its limit.
After mapping possible useful mutations of this virus, with E484K appearing to be of the most importance, we are possibly seeing the limits as to how far this virus can go. In the meantime, stay vigilant. Thank you @notdred for bringing this article up.
newyorker.com/science/medica…
So that no one is misinterpreting because I am seeing it already, this is meaning this might be the “worst” this virus can get. Also meaning, we are in a very good spot with more effective vaccine boosters on the way. We continue to stay on top of current VOCs with this mutation.
Read 5 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
7 Mar
Researchers in South Africa have found that antibodies of those previously infected with 501Y.V2 (B.1.351) are cross-reactive and thereby able to neutralize other variants of SARS-CoV-2 and prevent infection from other variants. Let’s discuss! 🧵
biorxiv.org/content/10.110…
Their research demonstrates immune response to B.1.351 is as potent as that seen in those infected with the original variant. Furthermore, antibodies from people infected with B.1.351 are not only able to neutralize B.1.351 but variant P.1 as well.
Blood samples from 89 patients in Cape Town, South Africa previously infected with SARS-CoV-2 were collected and sequenced. Their samples were all found to be that of B.1.351 by phylogenetic analysis. From previous accounts, we are aware that B.1.351 attributed to over 90% of
Read 15 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
3 Mar
I thought it was vital to bring this up as I am seeing this study circulate and being used in a lot of media today concerning Brazil’s variant P.1. Most of the misinformation over Brazil’s variant P.1 appears to stem from a single, unreliable serological survey in Manaus. 🧵
We can see the media has latched on to a study which claimed Manaus had reached herd immunity due to 76% of its population being previously infected with SARS-CoV-2. The claim was based on flawed serology data- its likely they never did. We now see that any reference to Manaus is
laced with fear of reinfection, despite there being no evidence of this on a larger scale. A follow-up study that received less publicity found that their peak was more like 15% rather than 76% that was being circulated and claimed.
thelancet.com/journals/langl…
Read 12 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

Like this author's thread?

Get emails when @sailorrooscout has new unrolls!

Check out other threads from @sailorrooscout!

Read all threads by @sailorrooscout