Thread by @MonicaGandhi9

Reviewing this paper again gives us 2 insights on why #covid19 seem so good at 1) reducing transmission (multiple studies now) & 2) likely to give long-last immunity. In terms of #1, protection against mucosal (e.g. nasal) asymptomatic infection
researchsquare.com/article/rs-310…

researchers have commented to you - it would be nice if vaccines make IgA antibodies. IgA antibodies are those that predominantly protect us against nasal infection/colonization but weren't measured in vaccine trials. This study shows vaccines induce plasmablasts which make high

levels of IgA after vaccination. So likely why we are seeing so many incredible real-world example that asymptomatic infection so reduced after vaccination & why CDC said no quarantine (ergo testing) if you are exposed after vaccination (if asymptomatic). No need for teachers

to have surveillance testing after vaccination unless symptomatic. Okay #2, this paper tells us about long-term immunity. Remember amazing Nature paper that those exposed to 1918 flu had memory B cells 90 years later that could produce neutralizing Ab
nature.com/articles/natur…

Well, our germinal center paper actually biopsied lymph nodes of those vaccinated and saw strong B cell responses (memory B cells) in those "germinal centers" (researchsquare.com/article/rs-310…). Portends well for long-term immunity and check, we have IgA for why reduce transmission.

I feel that no one truly appreciated from this the big deal that the #covid19 vaccines induce IgA immunoglobulins. Those are the ones that go into the NOSE to fight infection. Thanks