There are a lot of think pieces going around about the pandemic one year on. This is one of the best, from @jameshamblin, because it is upfront about the difficulties we face handling uncertainty. That's relevant to then, and now. A short 🧵commenting on the issues raised
The first thing to remember is that uncertainty about precise numbers is not an excuse to avoid action. This is a common misunderstanding about how mathematical modeling results should be interpreted. Depending on your inputs, you can get all sorts of results...
The goal is not to forecast exact outcomes, because you hope you never experience the world in which nobody intervenes *at all*, but to understand how seriously to take the threat. Qualitatively right is not the same as exactly quantitatively right.
True story: in the last week of February I was asked "what would happen if we did nothing?"
Me: "Really nothing? Nothing at all?

My companion: "Yes, nothing. Let it go and take its course"

Me: "Between 2 and a half and a 100 million people would die"
Now that is a MASSIVE range of outcomes. But the exact numbers are less important than the observation that the best case is really bad. For context, a really bad flu season would result in about 1.5 million deaths worldwide.
Of course by early March 2020, you don't need the math. Just look at the fact of what has happened to healthcare in Italy, Iran and Wuhan. In the last, the virus forced a regime allergic to accusations of disease cover ups to build two new hospitals in full view of the world!
Even now, you can find baroque arguments from some quarters that the deaths of the last year are not down to pandemic mismanagement, but knock-on effects of attempts to control the virus! The worst of these are close to conspiracy theories
However the more reasonable ones are worth taking on their merits. I agree that we need resources to help people handle restrictions. Giving workers PPE and sick pay would be a great start (reupping this link.springer.com/article/10.100…)
But overall, a year ago there was a freight train coming. What has amazed and disheartened me is the way that over and again, so many places have jumped back in front of it.
We now confront what will hopefully be the endgame. I started laying out what that might look like with @gyamey in this article time.com/5942246/elimin…
But it's not here yet. People are still getting infected, still getting long covid, and still dying. And as places like TX rush to reopen (again) it means there will be more of them
I started by saying we struggle with uncertainty. Here's some more for you. We don't yet know exactly how increasing population immunity, the changing seasons, human contact patterns and more contagious (and virulent) variants will interact. But some of them we can control
We can accelerate vaccination, we can keep cautious with our contacts, and give people most at risk the resources to protect themselves. And there *will* be a better future. I'm not going to say when exactly, but that's what I think, qualitatively
Finally - it may be that rather than a single 'end' to the pandemic, each of us will find ourselves looking back and realizing suddenly how far we have come, and how much better our world is, than in the darkest months of 2020/21
(and note that the pandemic is not going to end anytime soon in much of the world)
In this case the end of the pandemic will be evident in retrospect, and personal. And when that happens for each of us, depends on the actions taken by all of us

/end

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More from @BillHanage

1 Mar
A long sobering look at the pandemic in the UK. The success of the vaccine rollout should not obscure the way that leaders failed to heed the lessons of spring 2020 to an extent that beggars belief nytimes.com/interactive/20…
Look at the cumulative deaths. Around 40k in spring of last year. In other words ~2/3rds of the total are from the last few months (data from worldometers.info/coronavirus/co…)
While some of this is down to the emergence of B.1.1.7, it is mostly down to an attitude that resisted taking appropriate action, and ignored scientific advice. As many will know, I think 'led by the science' isn't the right way round - we should be led by those we elect. But...
Read 5 tweets
21 Feb
The thing is that much of this article could have been written at multiple points over the last year. Viruses are not influenced by bluster. Fortunately they are impacted by vaccine induced immunity. A few thoughts... 1/n
theguardian.com/commentisfree/…
Cases are falling quickly in the UK and elsewhere, which is great. The reasons are not clear, but it is reasonable to think that some of it is down to the comparatively rapid and effective vaccine roll out *together with* current numbers of contacts 2/n
If those numbers of contacts and opportunities for transmission increase, then we can expect cases to increase too. That is why caution is merited. The more people are protected by vaccination, the more contacts can happen, and there is something else... 3/n
Read 11 tweets
2 Feb
I think it is fair to say now that B.1.1.7 is definitely more transmissible, and possibly more virulent. This also reports cases that have acquired E484K, a mutation found in the other variants. This is concerning, but not reason to go crazy. A thread 1/n assets.publishing.service.gov.uk/government/upl…
First let's put to bed any suggestion that overdispersion in transmission explains B.1.1.7's rise. Consider data from Denmark, Ireland and now LA to mention only a few. It's behaving as we expect 2/n
This is the weekly increase in England documented in the linked report since early October. It's quite interesting that it's not taken over completely but don't want to speculate why 3/n
Read 15 tweets
1 Feb
I am all for large amounts of testing, but I doubt this will be sufficient to do more than slow things down (good in its own right of course). There's also not much in here on what will be done in the event of a positive test. theguardian.com/world/2021/feb…
That's what people forget. If a positive test does not lead to action that stops transmission, meaning support to allow isolation and quarantine of contacts, you're really only keeping score for the virus
Read 4 tweets
23 Jan
Some recent credible studies from the UK suggest that the variant B.1.1.7 which was first detected there is not only more transmissible but associated with greater severity, measured by deaths. A thread 1/n
The studies on which this is based are summarized in this document. Notably, it is not founded on one study, but several. They incorporate different data, methods and different biases and they are all imperfect, but they point in the same direction. assets.publishing.service.gov.uk/government/upl… 2/n
The upshot is that people infected with B.1.1.7 are about one third more likely to die than similar people infected with the pre-existing viral lineages. There is a LOT of uncertainty around that number. For a lot of reasons. But some increase (even if small) seems legit 3/n
Read 11 tweets
16 Jan
My announcement that I was running with a mask got a LOT of comment (from all sides) earlier. It’s in response to changes in the state of the pandemic and the transmissibility of the virus. Worth unpacking 1/goodness knows
First I posted the photo after a couple of interviews this week in which mask use outside was discussed in the context of surging infections due to the variant B.1.1.7. Here's one
And then this with RTE where were talked about mask use in the context of the situation in the Republic of Ireland, where cases are surging. I commented that I run with a mask. Hence the tweet

Read 13 tweets

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