Overall: 1.3%
In hospitalized patients: 7%
In patients needing ICU: 11%
6/ Risk of hospitalization in adults by BMI:
10% with BMI less than 25
17% with BMI 25-30
22% with BMI 30-40 (obesity)
26% with BMI >40 (severe obesity)
7/ Summary Table of Outcomes in children
8/ Although Mayo Clinic is a referral center the data in this paper come from 20 campuses in 4 states. And likely reflect the population served than a referral population.
Astra Zeneca vaccine has been paused in many European countries due to concerns about blood clots. What do we know. What does this mean?
1/ 17 million doses in UK and EU - To date 15 cases of deep vein thrombosis & 22 cases of pulmonary embolism. Rate is not higher than expected
2/However cases of blood clots veins in the brain, called central venous sinus thrombosis have been reported. These are very rare occurrences and this is concerning
3/ So far Denmark, Norway, Bulgaria, Iceland, France, Germany, Italy, Spain, Portugal, Slovenia, and Cyprus have suspended all use of the vaccine. Five other countries (Austria, Estonia, Latvia, Lithuania, and Luxembourg) have paused the use of a single batch of the vaccine.
50 million people in the US have received a COVID vaccine.
What changes after vaccination?
FAQ Thread 1. Do vaccinated people still need to wear masks around others?
Yes. For the time being, until enough people in the population are vaccinated.
There is concern that vaccinated people can still get asymptomatic COVID and then transmit it to others. Until a large proportion of the population is vaccinated please wear a mask to protect others.
2. But what if everyone in a small family or social group is vaccinated?
In a small group in which everyone has been vaccinated its OK to meet without masks. Risk is low
In work settings masks are still recommended as verifying vaccination & health status of coworkers is tricky
1.Which COVID vaccine should I get? Is one better than others?
You should get the vaccine you are offered. Getting a large number of people vaccinated is more important than differences in vaccine efficacy
2.Who cannot get the Pfizer COVID Vaccine?
Under the current EUA - those younger than 16 years cannot get the vaccine.
3. What about people with allergies? Can they get vaccinated?
Two nurses in the UK had a serious allergic reaction to the vaccine. Both had history of serious allergic reactions in the past that were severe enough to require that they carry epi pens.
The Pfizer vaccine has received Emergency Use Authorization in the UK and Canada and the vaccination campaign in the UK has commenced. An FDA expert panel has recommended approval of the Pfizer vaccine.
2/
44,000 patients were enrolled in the Pfizer-BioNTech trial. Half received two doses of the COVID-19 vaccine separated by 21 days, the other half received a placebo. Data from the first 36,621 patients was analyzed in mid-November
3/
1/ Vaccines may be the solution to ending the COVID-19 pandemic. Vaccines typically take several years to develop. But COVID vaccines are being developed at warp speed. More than 200 vaccines are in development.
2/
COVID vaccines in development are using different approaches
What are the stages of development of a vaccine?
Preclinical stage: Lab and animal studies to evaluate whether the candidate vaccine can trigger immune response
3/
Phase I trials: Done in a small group of volunteers to determine safety, dosage, and learn about the immune response it generates.
Phase II trials: Larger number of healthy volunteers (typically in the 100s or less) to learn more about safety and effectiveness.