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P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
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16 Mar, 4 tweets, 2 min read
High-dose aspirin for 2 weeks in type 2 diabetics dropped glucose from 190 to 92. All patients responded.

Indicates that inflammation is important in insulin resistance.

jci.org/articles/view/…
Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

Could be the (or one) source of inflammation. LPS come from gut bacteria so could indicate leaky gut as the source.

nature.com/articles/ijo20…

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More from @Mangan150

P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
17 Mar
Resistance training, aka strength training or lifting weights

Crucial for health and aging well.

Why?

Thread 👇
Resistance training builds muscle, and muscle is an underappreciated factor in health

"altered muscle metabolism plays a key role in the genesis, and therefore the prevention, of many common pathologic conditions and chronic diseases"

academic.oup.com/ajcn/article/8…
Aging is associated with loss of muscle.

Use it or lose it.

A large portion of the decline in cardiovascular fitness (VO2max) with age can be attributed to muscle loss. journals.physiology.org/doi/abs/10.115…
Read 17 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
13 Mar
Metabolic syndrome massively increases the risks for chronic disease.

What is it and why should you care?

Thread 👇
Someone has metabolic syndrome when they have at least 3 of the following 5 markers:

⬆️waist size
⬆️blood glucose
⬆️triglycerides
⬆️blood pressure
⬇️HDL cholesterol

Any 3 of those = metabolic syndrome

Any 1 = not 100% healthy

Metabolic syndrome is highly linked to obesity.
Metabolic syndrome is related to insulin resistance.

A classic study showed that people in the lowest third of insulin resistance had zero cases of heart disease, cancer, strokes etc.

Most were in the highest third.

Staying healthy means avoiding metabolic syndrome
Read 14 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
11 Mar
Industrial seed oils, aka vegetable oils, are still widely recommended as healthy.

But are they?

Thread 👇
Vegetable oils include a number of common cooking and dressing oils:

*canola
*soybean
*corn
*safflower
*sunflower
*and others

Note that they're not made from vegetables, but from seeds via an industrial process.

Olive and avocado oils are fruit, not seed, oils.
Until the late 19th century, these oils barely existed, and humans did not consume them.

But somebody got the bright idea of pressing the oil from cottonseeds, previously just a waste product.

Seed oils were born.
Read 14 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
9 Mar
Meat: does it harm your health

or is it in reality a superfood?

Let's take a look at the evidence.

Thread 👇
Everyone "knows" that meat is not healthy, but until a few decades ago, no one ever thought that.

Something changed.
What changed was the demonization of saturated fat as a cause of coronary heart disease by the (now notorious) Ancel Keys.

He used observational and cherry-picked data to "prove" his hypothesis.
Read 16 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
7 Mar
Weird to realize that there are professional carbohydrate defenders, and that the health establishment confers advanced degrees in Carbohydrate Defense.

Why?
Leaving aside the merits or demerits of carbs, the answer IMO hinges on saturated fat, which the health establishment has told us to avoid for decades.

They told us to eat carbs instead.

Therefore, if carbs fall, the nutrition establishment falls.

It was all a pack of lies.
If you're lean and healthy and you exercise with intensity regularly, there's likely nothing wrong with some carbs.

Although you might be surprised when that bowl of "healthy" oatmeal spikes your blood sugar to 180.
Read 4 tweets
P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture
7 Mar
Does insulin cause accelerated aging, and can you slow aging and live longer and in better health by keeping insulin levels low?

Let's look at the evidence.

Thread 👇
Insulin is a hormone secreted by the pancreas, which maintains normal blood glucose levels by promoting cellular glucose uptake, regulating carbohydrate, lipid and protein metabolism and promoting cell division and growth.

ncbi.nlm.nih.gov/pmc/articles/P…
Importantly, insulin resistance can occur, which is a lower response to insulin.

The result: insulin levels rise, leading to hyperinsulinemia.
Read 16 tweets

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