As we see an upward trend in cases, it's important to realise that we are seeing the natural course of the pandemic playing out.

➡️ Latest sero survey showed that a large % of us were still uninfected.
➡️ We've seen large social gatherings with most restrictions lifted.

1/6
➡️ Increased mobility across states, including crowded public transport.
➡️ New variants and possibility of waning antibodies.
➡️ Unfortunate non compliance to safety norms.
📣 It was only a matter of time that all these factors came together to result in another spike.

2/6
This time around, we have no national lockdown, rather we have activities back to 100% normalcy in most sectors and regions. This means that arresting the spread will be more challenging.

What can be done?
✅ One key study on the dynamics of transmission

3/6
in our 1st wave of infections had shown that 80% of cases originated from 5% of infected individuals. This showed the importance of super spreader events in transmission. It's critical that large scale gatherings - political, social, religious, entertainment are restricted.

4/6
✅ Speed up vaccination: Unlike last time, we have a shield to protect our most vulnerable: Vaccines.
We should administer vaccines at a war footing to prevent as many deaths at this juncture.

✅ More compliance: Let's accept it, there is laxity in following safety norms.

5/6
We need renewed public appeal to follow Covid19 safe practices. Influential political, social, religious leaders and celebrities should join in the appeal to drive up compliance.

📣 This is not about 1 state, multiple states are seeing a spike and the time to act is NOW.

6/6
For those interested in the paper that analysed transmission dynamics in AP and TN during the first wave - science.sciencemag.org/content/370/65…

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More from @covid19indiaorg

18 Mar
MH reported 25.8k new persons with Covid19 today. Highest daily count for the state yet, surpassing 24.8k recorded on 11/09/2020.

How are the 2 spikes different? Few quick points:

➡️ More rapid rise in cases: In Sept. last year, it took a month to double the 7DMA from....

1/5 Image
....10.5k cases/day to a 7DMA of 21k cases/day on 11th September.
Now, it has taken just 12 days for the 7DMA to double from 8k cases/day to 16k cases/day on 17th March.

The 7 day moving avg. graph of MH shows the steep slope for current spike. 👇

2/5 Image
➡️ Larger spike in certain districts: There are a number of districts that are seeing a stronger wave this time than in September last year.

Aurangabad, Akola, Amravati, Buldhana, Nagpur, Nanded, Nashik, Parbhani, Wardha, Washim, Yavatmal: Current case load > Sept. 2020.

3/5 ImageImageImageImage
Read 5 tweets
3 Mar
Encouraging news from #covaxin Phase 3, 1st interim analysis:

✅ Estimated efficacy of 80.6%.

Efficacy based on first 43 cases amongst the 25.8k trial participants. 36/43 in placebo group and 7 in vaccine group = 80.6% estimated efficacy.

1/3
Note that as per initial P3 trial design, 130 +ve cases is the target to analyze final P3 efficacy. Interim efficacy was to be analysed at 43 and 87 cases. So, be aware that this is the first milestone (43 cases) and efficacy can change over the course of trial.

2/3
We will have to see the detailed paper on these results to flag any exclusions etc.

Nevertheless, this should bolster public confidence, especially at a time when larger groups are being vaccinated.

3/3
Read 4 tweets
3 Mar
A wonderful compilation of vaccination experience shared by our readers across different cities.

It's a diverse set - some fully through Co-WIN, some walk-in, some Co-WIN + walk in etc.
Different locations have different ways of making it work.

Catch the thread below 👇

1/n
Bengaluru:
My mother was the 1st person to be vaccinated in KA. We registered sharp at 9AM got the appointment and went and got vaccinated at 12 noon after inauguration. It's important to repeatedly try as server is loaded some of my relatives got appt after multiple tries.

2/n
Faridabad, Haryana:
Yes parents did it today at a private hospital. It was walk-in and took less than 30mins, was seamless process very well managed.

3/n
Read 13 tweets
1 Mar
Experience of a volunteer in our team who was able to book vaccination appointment on cowin.gov.in today:

➡️ Accessed the website few minutes past 9am. Entered mobile number to receive OTP.
➡️ Initially there was a delay in receiving the OTP.

1/n
➡️ The website took quite a while to move from the first screen to the next where OTP could be entered.
➡️ Received the OTP after a wait of 5 to 10 minutes. This looked to be an initial issue. Subsequent requests for OTP happened without delays.

2/n
➡️ Was presented with a screen to enter details of vaccine beneficiary. The data entry was straightforward with ID card type, number, name gender and year of birth required to be entered.
➡️ After doing the registration, there was option to enter additional beneficiaries.

3/n
Read 12 tweets
27 Feb
Initial guidelines on next phase of vaccination starting on 1st March.
Important read.

✅ Eligible groups: (a) All citizens above 60 yrs. of age. (b) Those between 45 to 59 yrs of age, but with SPECIFIC COMORBIDITIES.

✅ Empanelled private sector hospitals to be included.

1/n
✅ 3 Modes of registration:
➡️ Advance Self Registration: Prior registration using CoWIN 2.0 app (yet to be available for public?).
➡️ On-site Registration: Walk-in registration at vaccination centers.
➡️ Facilitated Cohort Registration: Specific groups mobilized by...

2/n
the state and brought to the vaccination centers.

✅ All beneficiaries, irrespective of mode of registration to carry one photo id card as per acceptable list of documents.

✅ Free at Govt. Centers.
Pvt. Centers can charge upto INR 250/dose.

3/n
Read 4 tweets
22 Feb
With news of Dr. Reddy's applying for accelerated approval of 'Sputnik V' vaccine, here is a quick summary of the potential candidate:

✅ Vaccine platform: Viral vector technology using Adenovirus as the vector. Covishield uses the same platform, but there is a difference.

1/n
✅ Sputnik V uses 2 different variants of the human adenovirus for the 1st and 2nd dose, unlike Covishield where both doses use the same variant of a chimpanzee adenovirus.

✅ Who is developing this vaccine? Gamaleya Research Institute, Russia.

2/n
✅ Has the vaccine got approval in other countries? Russia stirred critical discussions when use of Sputnik V was authorized in Russia before completion of trials. Subsequently Phase 3 interim results have been published.
20+ countries have given emergency approval.

3/n
Read 9 tweets

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