1/4 Costs of PCSK9 antibodies (initially $14k/yr, now ~$5-6/yr) will come up, so here is a brief summary of this.
1- antibodies are very expensive to make as they are large proteins and have to be made in a biological system rather than chemical synthesis
@stsimikas @OxPL_apoB
1- antibodies are very expensive to make as they are large proteins and have to be made in a biological system rather than chemical synthesis
@stsimikas @OxPL_apoB
2/4 2- I dont know what they break even point is, but I suspect you cant make them for <$2-3K/yr, so price will not likely come down more as there will be little profit.
3- at 150 mg every 2 weeks, this is 3,900 mg/yr per patient, so cost is ~$1.50 per mg
3- at 150 mg every 2 weeks, this is 3,900 mg/yr per patient, so cost is ~$1.50 per mg
3/4 4- for context, in our research lab, 0.1 mg of most research antibodies, that don't need human testing, is ~$300, or ~$3000/mg, i.e about 1500 times more expensive that Repatha and Praluent. If we had to buy 3,900 mg per year, it would cost us over $100,000K
4/4 5- ASOs will be cheapest to make, followed by siRNA, as they are ~20x smaller than antibodies. siRNA is 2 chains, ASOs one, so half the price theoretically.
6- nonetheless, for many drugs, the cost to make and the price to consumer are often disjointed, due to market forces
6- nonetheless, for many drugs, the cost to make and the price to consumer are often disjointed, due to market forces
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