AstraZeneca’s data from their clinical trials in the U.S. along with studies in Chile and Peru now in sync with the Data and Satety Monitoring Board is here!

•76% effective against symptomatic COVID-19

•100% effective against severe illness

•No safety concerns reported
Comparable efficacy result across ethnicity and age. 85% efficacy in participants aged 65+. These were 4-week dose interval.
astrazeneca.com/media-centre/p…
Want to emphasize again, this efficacy was achieved using a 4-week dosing interval. The 12-week dosing interval used in the UK doubles levels of neutralizing antibodies, further increasing protection, hence results could have had the potential to be higher.
I’ll say this much on the matter. I don’t personally feel this warranted an emergency statement overnight. I think that could have been handled in a more private manner. The changes from 79% to 76% didn’t warrant that when you consider how detrimental a hit to vaccine confidence
is, especially right now. What is important to know is this vaccine is safe, effective, easily distributed, and cost-effective. It can help several countries and it has proven itself in RW data time and time again. I would not hesitate to get it.

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More from @sailorrooscout

24 Mar
Vaccines are preventives NOT cures. You can still contract the virus once vaccinated. The vaccines are here to make sure you don’t suffer from a severe case or worse. What you need to know is none of these individuals have severe symptoms. Therefore, the vaccines are WORKING.
Also PSST. Know what this means? This means those cell-mediated immune responses are kicking in and your T-cells have once again come to the rescue!
The department confirmed in a statement that none of the three people became severely ill after contracting the virus and did not appear to pass it on to anyone else. Vaccines WORK. ✨
Read 4 tweets
23 Mar
Dear Politicians,

Stop playing Scientists. You’re making our jobs a lot harder than they need to be.
In regards to NIAID’s statement on AstraZeneca, it is indeed quite bizarre of them to produce quite a statement overnight. We need to wait for the FDA’s documents which will ultimately have to be reviewed by NIAID as well. The real-world data on this vaccine speaks for itself.
With this said, excuse my French, but any damn country that doesn’t want to use that vaccine needs to hand it over and give it to those that need it now. People are struggling and all we are doing is sitting on our damn hands. Stop this mess.
Read 6 tweets
18 Mar
There had been a lot of concern surrounding fertility and pregnancy with the vaccines. I thought it would be nice to share the wonders of passive immunity as the first baby with antibodies against COVID-19 in the United States was born yesterday.
At 36 weeks pregnant, the South Florida frontline health care worker had received their first dose of Moderna’s vaccine.
cbsnews.com/news/covid-vac…
Do excuse the “yesterday” part! Apparently it was slow off the press! medrxiv.org/content/10.110…
Read 4 tweets
17 Mar
Super excited to share this. New data from the New England Journal of Medicine shows Moderna’s mRNA-1273 vaccine significantly reduces neutralizing activity against VOCs B.1.1.7, P.1, and B.1.351 and VOI B.1.427/B.1.429. The results are very encouraging!🧵
nejm.org/doi/full/10.10…
Researchers assayed the neutralizing activity against recombinant vesicular stomatitis virus (rVSV)–based SARS-CoV-2 (a pseudovirus-based model) in serum samples obtained from eight participants in our Phase 1 trial. The samples were obtained one week after participants had
received the second dose of mRNA-1273 vaccine. They then tested pseudoviruses bearing the spike proteins from the original Wuhan-Hu-1 isolate, the D614G variant, and the B.1.1.7, B.1.351, P.1, B.1.427/B.1.429, B.1.1.7+E484K, and other variants (20E [EU1], 20A.EU2, N439K-D614G,
Read 9 tweets
15 Mar
“mRNA vaccines are gene therapy.” Yeah, that’s false. If you see someone claim this, they aren’t worth their salt as a scientist. Sorry not sorry. For one, this is mRNA we are talking about not DNA. Yes, there is a difference.
Gene therapy implies the use of DNA, which stays in your body and can be incorporated into your chromosomes. RNA doesn’t do this. The mRNA in our vaccines wouldn’t be converted into DNA because the enzymes capable of doing that aren’t present. Yeah, those are necessary, trust me.
Lastly, the mRNA strand is not stable enough to hang around. This is what lipid nanoparticles are for. We encased the mRNA so that it maintains its integrity and doesn’t get damaged as it enters cells. After the strand is read the mRNA then degrades. It doesn’t alter your DNA.
Read 4 tweets
14 Mar
I think it’s important to note vaccines will not cause blood clotting related disorders. The reported numbers of these types of events you are seeing in the media for these vaccines are not greater than the number that would have occurred naturally in the unvaccinated population.
In reference to AstraZeneca’s vaccine: the UK has given over 10M doses of this vaccine and Pfizer’s vaccine. Number of blood clot related events: AZN had 13, Pfizer had 15. Also no, the vaccines don’t destroy your innate immune system nor do they alter your DNA. They never have.
It is an understatement when I say the irreparable damage that is being done right now is devastating. There are countries (including the U.S.) sitting on a stockpile of this vaccine that could be going to those who desperately need it. I have never seen a virus more politicized.
Read 7 tweets

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