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Mac n’ Chise 🧬🦠🧫 Profile picture
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15 Mar, 4 tweets, 1 min read
“mRNA vaccines are gene therapy.” Yeah, that’s false. If you see someone claim this, they aren’t worth their salt as a scientist. Sorry not sorry. For one, this is mRNA we are talking about not DNA. Yes, there is a difference.
Gene therapy implies the use of DNA, which stays in your body and can be incorporated into your chromosomes. RNA doesn’t do this. The mRNA in our vaccines wouldn’t be converted into DNA because the enzymes capable of doing that aren’t present. Yeah, those are necessary, trust me.
Lastly, the mRNA strand is not stable enough to hang around. This is what lipid nanoparticles are for. We encased the mRNA so that it maintains its integrity and doesn’t get damaged as it enters cells. After the strand is read the mRNA then degrades. It doesn’t alter your DNA.
Someone might ask: “Chise why are you addressing this?” Trust me, at this point in time I didn’t think I would be either but, I digress. It is indeed something circulating unfortunately so I figured it was important to address and debunk right now.

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Mac n’ Chise 🧬🦠🧫 Profile picture
14 Mar
I think it’s important to note vaccines will not cause blood clotting related disorders. The reported numbers of these types of events you are seeing in the media for these vaccines are not greater than the number that would have occurred naturally in the unvaccinated population.
In reference to AstraZeneca’s vaccine: the UK has given over 10M doses of this vaccine and Pfizer’s vaccine. Number of blood clot related events: AZN had 13, Pfizer had 15. Also no, the vaccines don’t destroy your innate immune system nor do they alter your DNA. They never have.
It is an understatement when I say the irreparable damage that is being done right now is devastating. There are countries (including the U.S.) sitting on a stockpile of this vaccine that could be going to those who desperately need it. I have never seen a virus more politicized.
Read 7 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
8 Mar
Look at those antibodies!
The latest from the New England Journal of Medicine shows the effective neutralization assessed with serum from participants vaccinated with 2 doses of Pfizer’s BNT162b2 COVID-19 vaccine against VOCs B.1.1.7, B.1.351, and P.1.
nejm.org/doi/full/10.10…
To analyze effects on neutralization elicited by Pfizer’s vaccine, researchers engineered spike mutations from the from the current VOC lineages. They then performed 50% plaque reduction neutralization testing (PRNT50) using 20 serum samples that had been obtained from
15 participants in the pivotal trial 2 or 4 weeks after the administration of the second dose of 30 μg of Pfizer’s vaccine (which occurred 3 weeks after the first immunization). All the serum samples efficiently neutralized their isolate and all the viruses with variant spikes.
Read 6 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
8 Mar
The CDC says fully vaccinated people do not need masks or social distancing when meeting indoors with those at low risk for COVID-19. The rest of the guidelines are as follows. 🧵
The CDC defines people who are fully vaccinated as those who are two weeks past their second dose of the Moderna and Pfizer Covid-19 vaccine or two weeks past a single dose of the Johnson & Johnson vaccine.
The CDC says fully vaccinated people can:
-Visit other vaccinated people indoors without masks or physical distancing

-Visit indoors with unvaccinated people from a single family without masks or physical distancing, if the unvaccinated people are at low risk for severe disease.
Read 13 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
8 Mar
Remember weeks ago when I spoke about variants, selective pressure, and convergent evolution? The emerging variants we see all seem to adapt the E484K escape mutation. What does this mean? It means SARS-CoV-2 might have just played its best card and its reaching its limit.
After mapping possible useful mutations of this virus, with E484K appearing to be of the most importance, we are possibly seeing the limits as to how far this virus can go. In the meantime, stay vigilant. Thank you @notdred for bringing this article up.
newyorker.com/science/medica…
So that no one is misinterpreting because I am seeing it already, this is meaning this might be the “worst” this virus can get. Also meaning, we are in a very good spot with more effective vaccine boosters on the way. We continue to stay on top of current VOCs with this mutation.
Read 5 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
7 Mar
I figured it was important to highlight this, especially when you might see fear-inducing headlines about this variant spreading quickly. B.1.1.7 now accounts for 20% of our cases in the U.S., HOWEVER we are seeing our lowest case counts now since October.
nytimes.com/interactive/20…
Even in states with low-restrictions we’re not seeing a resurgence in overall infections. While we are not fully in the clear yet, a combination of increased vaccinations, higher levels of natural immunity, and other mitigation efforts will help us avoid sharp spikes in cases.
Yesterday, the U.S. set a record of 2.9M vaccines administered, getting closer to the goal of 3M+ administered daily. This is the opportune time to gain an advantage with mass vaccination efforts as vaccine supply increases.
Read 5 tweets
Mac n’ Chise 🧬🦠🧫 Profile picture
7 Mar
Researchers in South Africa have found that antibodies of those previously infected with 501Y.V2 (B.1.351) are cross-reactive and thereby able to neutralize other variants of SARS-CoV-2 and prevent infection from other variants. Let’s discuss! 🧵
biorxiv.org/content/10.110…
Their research demonstrates immune response to B.1.351 is as potent as that seen in those infected with the original variant. Furthermore, antibodies from people infected with B.1.351 are not only able to neutralize B.1.351 but variant P.1 as well.
Blood samples from 89 patients in Cape Town, South Africa previously infected with SARS-CoV-2 were collected and sequenced. Their samples were all found to be that of B.1.351 by phylogenetic analysis. From previous accounts, we are aware that B.1.351 attributed to over 90% of
Read 15 tweets

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