Thread by @sailorrooscout

A study finds vaccination boosts cross-variant neutralizing antibodies elicited by previous SARS-CoV-2 infection. Immunization generated B and CD4+ T-cell responses AND a 1000-fold increase in neutralizing antibody titers against B.1.351!🧵
science.sciencemag.org/content/early/…

Researchers examined whether sera from recovered and naïve donors collected prior to, and following immunizations with existing mRNA vaccines, could neutralize the Wuhan-Hu-1 and B.1.351 variants. Pre-vaccination sera from recovered donors neutralized Wuhan-Hu-1 and sporadically

neutralized B.1.351, but a SINGLE immunization boosted neutralizing titers against all variants and SARS-CoV-1 by up to 1000-fold. Neutralization was due to antibodies targeting the RBD and was not boosted by a second immunization in recovered donors.

B.1.351 variants show decreased susceptibility to neutralizing monoclonal antibodies. Researchers evaluated the neutralizing potency of several mAbs isolated from non-vaccinated patients infected early in the pandemic. Our natural immune response alone isn’t enough to withstand.

We see a with just a single dose of a spike-derived mRNA vaccine, strong recall responses are elicited in participants. You have to love cell-mediated immunity. Seriously. Your memory B-cells and T-cells are here to protect you and that vaccine is the jumpstart!

Pre-existing SARS-CoV-2 neutralizing antibody responses are literately boosted by a single dose of a spike-derived mRNA vaccine. I mean, look at those antibodies! And that’s against B.1.351 too! 🚀 By the way, they’re neutralizing other additional variants too. Cross-reactivity!

And just so we are all on the same page. Vaccine-elicited neutralizing antibodies target the RBD.

Immunization of naïve donors also elicited cross-neutralizing responses, but at lower titers. This study emphasizes the importance of vaccinating BOTH uninfected and previously infected individuals to elicit cross-variant neutralizing antibodies against SEVERAL variants.

Also before anyone asks, this is peer-reviewed. Again, I cannot make anyone get a vaccine, however, given this information, even if you have had a previous SARS-CoV-2 infection, the benefits of at least getting one dose (while the rest of us who haven’t get two) are monumental.

I’m seeing an FAQ so let me answer it this way: nAbs response in previously infected + one dose is equivalent to the nAbs response to not previously infected + two doses.

Also another FAQ. What’s the advantage for those who have had a previous SARS-CoV-2 infection? Besides that stellar 1000-fold nAbs response, cross-reactivity against other variant strains!