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Eric Feigl-Ding Profile picture
@DrEricDing
Mar 27, 2021 • 13 tweets • 9 min read • Read on X
Let this sink in—

The more contagious #P1 variant from Brazil has now invaded N America—British Columbia🇨🇦 has a sudden cluster of 215+ new #P1 cases sequenced by one Vancouver lab.

#P1 is more contagious, has reinfection risk and possibly more severe.🧵
2) 215 identified by one lab in Vancouver — and not all even included in public reports by BC health Dept yet (they are much slower reporting than CTV news)

BC 🇨🇦 has added 20-30 daily #P1 cases per day for the last 4 days (again not including all the #P1 above)
3) And are these new #P1 cases due to international travel or were they local transmission?

The BC health Dept report few days ago said the initial 84 cases were all community transmission!! Zero international travel. This is a bad sign — so many at once and no travel. Image
4) One Brazil @obscovid19br study puts #P1 transmission at 2.5x faster than old common strain. This 150% increase is much faster than even #B117 if it holds up.
5) Meanwhile, another UK group at MRC Imperial puts #P1 at 2x (100% increase) more transmissible than older common strains— but with even larger reinfection potential.

Keep in mind #b117 from UK is only 40-60% faster than old common. Both studies imply #P1 is faster than B117.
6) And is there early data suggesting #P1 is more severe?

“an increase in CFR for almost all age groups observed. All groups above 20 years of age showed significant increases in CFR (Case Fatality Ratio)”

when comparing February 2021 vs January 2021...
medrxiv.org/content/10.110…
7) Notably:

📌Patients aged 20-29 years experienced a tripling of their CFR

📌aged 30-39, 40-49, 50-59 experienced ~CFR doubling

➡️”Individuals between 20-29 years of age in February 2021 had an over 3-fold higher risk of death compared to January 2021.” Image
8) “findings suggest significant increases in CFR in young and middle-aged adults after identification of a novel SARS-CoV-2 strain circulating in Brazil, and this should raise public health alarms” ⚠️
9) British Columbia’s recent #P1 spike isn’t the first outside Brazil 🇧🇷. As alluded to in the video (top post), there are surges also in neighboring Paraguay and Uruguay— where ICU hospital beds are now maxed out. see thread 🧵 below.
10) We need to all prevent #P1 from causing more clusters and hotspots around the world. Because we cannot repeat the crisis in Brazil 🇧🇷 right now. See detailed #P1 thread below.
11) Head scratching frustrating — I don’t know why BC health chief keeps dismissing the variants of concern (B117 P1 and B1351) as not different than older strains. That is clearly false (see above) and well known for months. @CDCofBC 🇨🇦 needs to wake up.
12) UPDATE—after some weekend pressure, BC 🇨🇦 health chief Bonnie Henry finally admits there is a serious issue with #P1 variant - now announced discovery of 270 cases in BC! And she finally admits P1 is a problem. BC now on short circuit breaker.
13) Bad update— another 100 new cases of #P1 variant logged in BC 🇨🇦 today. This is exponential.

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More from @DrEricDing

Eric Feigl-Ding Profile picture
Feb 26
BREAKING—FDA suddenly cancels meeting to update next season’s flu vaccines, with zero explanations. Any delays will jeopardize next year’s vaccine supply chain. Image
2) Folks who follow me know that I’m no bullshitter. I criticized past pandemic response right and left, and have called balls and strikes without bias. And I often say things that doctors & epidemiologists are whispering among themselves but don’t say publicly. (Cough cough) ⬇️
3) While I don’t recommend hoarding… I think stocking up on flu antivirals, which you can obtain prophylactically (preventively) from doctors if you ask nicely why you’re high risk, can be a good idea. I know many doctors, epidemiologists and virologists who do for their family.
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 26
Doctors are debunking RFK Jr’s claim that 20 hospitalized measles cases in Texas are there for mainly quarantine. Doctors on the ground say the 20 kids hospitalized are having trouble breathing. Oh and they are all unvaccinated against measles, which RFK Jr neglects to mention. Image
2) RFK Jr told Trump today there’s now 2 measles deaths.
3) RFK Jr is a tear with his FDA today. A dark Darwinian future lies ahead for America.
Read 4 tweets
Eric Feigl-Ding Profile picture
Feb 26
BREAKING—Reports coming in about potentially *2 measles deaths* in Texas, not just one, according to an HHS briefing to the White House today.
2) Earlier today, one measles death in an unvaccinated child was reported in Texas. Image
3) It seems to be RFK Jr who said it in an official Trump WH cabinet meeting today. Not saying he doesn’t lie, but he is now HHS Secretary
Read 6 tweets
Eric Feigl-Ding Profile picture
Feb 21
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏 Image
Image
Image
2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”

pmc.ncbi.nlm.nih.gov/articles/PMC10…
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
Read 5 tweets
Eric Feigl-Ding Profile picture
Feb 16
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)Image
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2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)."
nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.

"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"Image
Read 13 tweets
Eric Feigl-Ding Profile picture
Feb 14
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts. Image
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2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...

If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here.
cdc.gov/fluvaxview/das…Image
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.
Read 7 tweets

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