Aberrant #glycosylation of anti-Spike antibodies promotes #thrombosis as observed in severely ill #COVID19 patients. Very interesting work from our collaborators in the UK: biorxiv.org/content/10.110…. A few thoughts on why this could be important. 1/4
Severely ill patients make IgG with aberrant glycosylation. We previously showed that this (over)activates lung macrophages, which in turn activates endothelium, which in turn activates platelets. But this paper shows that the antibodies (over)activate platelets directly! 2/4
Interestingly, anti-Spike IgG with “normal” glycosylation (mild COVID-19 patients) has no effect. Only IgG with the combination of low fucose AND high galactose (severely ill patients) promotes thrombosis. In contrast, (over)activation of macrophages only requires low fucose. 3/4
The good news: several drugs can counteract this overactivation of platelets in vitro, including #fostamatinib and #ibrutinib. And the first data from the COVID-19 clinical trial with fostamatinib should be available soon… @RigelPharma 4/4
And now with the corrected link (thanks for pointing out @DaveLeeERMD!): biorxiv.org/content/10.110…
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