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Hannah Davis 🦈 Profile picture
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30 Mar, 4 tweets, 3 min read
This new paper on 323 PCR positive #longhaulers containing a really crucial finding:

Low IgG levels in the acute phase were associated with persistent symptoms 7 months later! #LongCOVID 1/

medrxiv.org/content/10.110…
I do think there is mounting evidence that people with #LongCOVID have disproportionately low antibody levels, and that might be key to understanding the illness. It's also a crucial reason why people without antibodies need to be included in #LongCOVID research. 2/
The big downside of this paper is they only asked about 9 symptoms, none of which were neurological (like sensorimotor issues, "brain fog") except headache. Of those 9, they found that diarrhea or loss of smell in the acute phase were predictive of #LongCOVID at 7 months. 3/
The above paper was on non-hospitalized long haulers, but is consistent with this paper that *also* found that low IgG levels were a risk factor for developing #LongCovid in hospitalized patients. 4/

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More from @ahandvanish

Hannah Davis 🦈 Profile picture
28 Mar
Because @itsbodypolitic is on Slack, it has the ability to have mini-support groups within the larger group. This is a reminder that it has specific (private) channels for #LongCOVID patients who are:

1. Medical professionals
2. BIPOC
3. LGBTQ+
4. Men

wearebodypolitic.com/covid19 1/
There is also a new Japanese-language channel for Japanese-speaking #longhaulers! cc @ygjumi 2/
There are a total of 61 channels on many topics, including symptom-specific channels (neurological, endocrine, reproductive health, GI, circulatory), but also advocacy, financial concerns, parents/#LongCOVID children, vaccine responses, & many more. If you are suffering, join! 3/
Read 4 tweets
Hannah Davis 🦈 Profile picture
27 Mar
It has been *amazing* to see so many patient researchers with #LongCOVID. Here's another paper from the UK with folks from @long_covid support group - huge congrats @Dr2NisreenAlwan, @ClaireHastie1, @Know_HG, @dgurdasani1, & team!

A few findings that stood out: 1/
This is a big deal: adequate rest in the early weeks was protective against a more severe #LongCOVID category (measured by fatigue, ability to work, care for self, etc).

Also! Higher income was protective against ending up in this category as well. 2/

Those are two factors that are crucial to talking about #LongCOVID recovery: people need adequate time to rest, and there are huge inequalities in who is able to and can afford to do that! 3/
Read 9 tweets
Hannah Davis 🦈 Profile picture
26 Mar
A year ago today I had my first COVID symptoms, and I never recovered.

It feels fairly impossible to process what being sick for a year has been like, and what this year of watching #LongCOVID awareness and advocacy unfold has been like, but some thoughts: 1/
The first week of being sick was the easiest. I remember marking my calendar to donate plasma at the point I expected to be symptom-free, but that never came. The sirens in NYC were nonstop at that point. I watched my neighbors get taken away in ambulances. 2/
Every night from 2-4am the neighbor closest to my bedroom window had a coughing fit. It was so weird and horrifying to know we were all experiencing the same thing. In those days living in NYC was a horror show while the rest of the country had no idea how bad it was. 3/
Read 20 tweets
Hannah Davis 🦈 Profile picture
22 Mar
An excellent piece by @DocAmali on why COVID and #LongCOVID support groups need to be ethical in their practices, including protecting the privacy of the patients who participate. Otherwise, they risk "objectification and exploitation of vulnerable participants."
This is why @itsbodypolitic is a private, patient-only support group hosted on a platform that doesn't exploit participant data, and has rules that explicitly prohibit scraping of support group data! #LongCOVID

@DocAmali's call to action: "Governments & regulators internationally should collectively develop policies to combat unconsented use of social media data for healthcare research, & also bring in new laws to prohibit unethical data mining of social media platforms."
Read 4 tweets
Hannah Davis 🦈 Profile picture
21 Mar
.@YoDoctorYo @brucep13 have you seen this paper? it shows elevated cytokines in early ME patients (<3 years) that decrease in patients who have ME for longer than 3 years. How does this relate to the long hauler index “improving”/decreasing? #LongCovid

advances.sciencemag.org/content/1/1/e1…
Lots of expert authors on this paper, including @mhornig @LBatemanMD @ngklimas
@YoDoctorYo thanks for replying but my question hasn't been answered. Specifically: they found similar elevated cytokines as you (like IFN-γ) in early ME patients, that decrease in later ME. How do you know a decrease means an improvement & not exhaustion as theorized here?
Read 4 tweets
Hannah Davis 🦈 Profile picture
20 Mar
This is one of the wilder papers I've seen - PCR tests for COVID are over twice as likely to be positive in the early afternoon. 1/

medrxiv.org/content/10.110…
"The strong diurnal sinusoid pattern in the fraction of positive tests suggests a cyclic pattern in viral shedding, with a peak in the early afternoon. This aligns with previous findings for other viruses such as influenza, herpes, and dengue... 2/
...where interactions with the immune system lead to diurnal variation in viral shedding and symptoms, and have been shown to influence vaccine effectiveness."
3/
Read 4 tweets

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