Weekend Digest

An Korean immigrant presented with early stage cholangiocarcinoma.

H & E stained tissue biopsy shown.

Name the pathogen and mechanism of infection.
2/
Case Diagnosis:
#Clonorchis sinensis - oriental liver fluke

“The eggs of Clonorchis are practically indistinguishable from those of #Opisthorchis” (photo credit: CDC)
3/
#Chlonorchis sinensis (and #Opistorchis)

Human infection is acquired by ingestion of undercooked, salted, pickled, or smoked freshwater fish (with metacercariae)

—> excyst in duodenum —> ascend biliary tree —> mature into adults in biliary ducts

cdc.gov/dpdx/clonorchi…
4/
#Chlonorchis sinensis (and #Opistorchis)

Clinical: inflammation / obstruction / mechanical injury of biliary ducts

Complications (cholangitis, cholelithiasis, cholecystitis, and cholangiocarcinoma), pancreatitis, and liver abscesses may develop.

ncbi.nlm.nih.gov/pmc/articles/P…
5/
#Chlonorchis sinensis Rx

Praziquantel is treatment of choice

Alternative: albendazole

Plus: surgery if biliary obstruction and cancer
6/ Bonus tweet:

Name the liver fluke that is endemic in North America.
7/
#Metorchis conjunctus

Here is a report of common-source outbreak of 19 people who ate sashimi made from white sucker fish caught in a river in Montreal

Clinical: abdominal pain, eosinophilia, elevated liver enzymes + opistorchid eggs in stool

thelancet.com/pdfs/journals/…

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Mayo Clinic Infectious Diseases

Mayo Clinic Infectious Diseases Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @MayoClinicINFD

1 Apr
Images of Infectious Diseases

This is middle turbinate of a 64 ICH with epistaxis s/p CAR-T for refractory diffuse large B cell lymphoma.

What is your DDx? #MayoIDQ next Image
64M refractory DLBCL
s/p CAR-T —> cytokine release syndrome Rx tocilizumab and steroids

CC: epistaxis x 2w
PE: lesion in hard palate; nasal endoscopy (photo). CT dense material in sinuses.

What is next best step?
3/
Biopsies from left hard palate and nasal cavity lesions were obtained (photo). Culture: Fusarium sp.

Suggested answer: ENT surgery for biopsy / diagnostics + debridement

Often: diagnostics and empiric Rx are concurrent in real life. Image
Read 4 tweets
23 Mar
Images of Infectious Diseases

H&E of brain biopsy specimen.

Who is the host? What is the most likely pathogen? How do you treat?
#MayoIDQ Image
2/ #MayoIDQ
75F. Immunocompetent.
CC: headache x few months —> now left leg weakness, blurred vision, seizure. CBC/CMP normal. CT head: mass in right ventricle, pons. CT chest/abdomen for CA work up (-). Brain biopsy (photo).

Which of the following is the most likely pathogen?
3/
Case diagnosis: cerebral #phaeohyphomycosis due to #cladophialophora

Note pigmented hyphae —> excludes Aspergillus (hyaline septate mould)

Among 3 remaining choices, the most common neurotrophic dematiaceous mould is Cladophialophora bantiana
Read 7 tweets
9 Mar
#MayoIDQ #IDBR
45M CC: tender mass on left thigh that started as an “insect bite” 4 days ago. No F/C. PE: tender fluctuant 2-cm mass with surrounding erythema.

After I&D of abscess in the clinic, what do you recommend?
2/
2014 IDSA guideline recommends incision and drainage of purulent SSTI (abscess)

Antibiotics vs MRSA / S. aureus as an adjunct to I&D if:
1. SIRS
2. Failed initial Ab Rx
3. Impaired host defense

Any new data since then?

doi.org/10.1093/cid/ci…
3/
After 2014 IDSA guideline, placebo-controlled RCTs were published on use of antibiotics (TMP SMX or clindamycin) for uncomplicated SSTI abscess ... (next)

ncbi.nlm.nih.gov/pmc/articles/P…
Read 5 tweets
2 Mar
#MayoIDQ: 86M DM

2 wk of R ear pain / nasal discharge

Now: R frontal HA, facial pain, vision loss

PE: R ptosis, CN III, IV, VI palsies, purulence R middle meatus

CT: R sided paranasal sinusitis w/ phlegmonous extension to orbital apex

What is DDx, work up and etiology?
2/
Diagnosis: Orbital Apex Syndrome

S/S due to involvement of structures in orbital apex: most common vision loss and painful / limited eye movement

CN palsies
* Optic nerve
* Oculomotor nerve
* Trochlear nerve
* First division of trigeminal nerve
* Abducens nerve
3/
DDx (overlapping symptoms) of orbital apex syndrome

1. Cavernous sinus thrombosis
2. Superior orbital fissure syndrome

ncbi.nlm.nih.gov/pmc/articles/P…
Read 7 tweets
27 Feb
Weekend Digest

Name the disease and its pathogen, risk factor, prevention and treatment.
2/
Disease: #Anisakiasis

Pathogens (most common):
Anisakis simplex complex
Pseudoterranova decipiens complex
Contracecum osculatum complex

Photo credit: doi.org/10.1016/j.ijid…
3/
Risk factor #Anisakiasis

Consumption of raw / undercooked fish / squid

“Ascaridoid” nematodes (roundworm) of whales, seals (“seal worm”), marine mammals —> eggs excreted in water —> larva in crustaceans —> ingested by fish (“herringworm”, “codworm”) —> consumed by humans
Read 7 tweets
25 Feb
Images of Infectious Diseases

28F SLE on MTX
CC chest pain, vaginal DC
Rx pred for lupus

2 mo: fatigue, pruritic rash, visual floaters Rx pred

1 mo: blurred vision. PE iritis / chorioretinitis. Rx pred

Now b/l vision loss. PE panuveitis + chorioretinitis

DDx? #MayoIDQ Image
2/
28F HIV/HBV/HCV(-) SLE on MTX w chronic pain Rx as flare, vaginal discharge due to BV Rx metro (negative GC/chlamydia), skin rash x 2 w and progressive vision loss (photo). CXR clear. Indiana / no foreign travel. No animal exposures.

What is most likely diagnostic test?
3/
Case diagnosis: bilateral ocular syphilis with neurosyphilis

RPR 1:512
Syphilis antibody with reflex: positive
CSF VDRL 1:1

Rx: IV penicillin
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!