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Nick Norwitz

@nicknorwitz

Apr 13

What if all *autoimmune diseases* were stemming from the same source, from a seed planted 2 Billion years ago that’s just beginning to flower? 🔥🤔🧵

1/6) That might sound wild—but it’s actually the central thesis of a perspectives paper published in @Nature, which proposes that many autoimmune diseases may be driven by the failure of a relationship that began 2 billion years ago: the one between your body and your mitochondria.

For me, this idea carries personal weight since I suffered from debilitating inflammatory bowel disease, which went into remission on a ketogenic diet.

I’ve seen others similarly put IBD, lupus, multiple sclerosis, and rheumatoid arthritis into remission with lifestyle change.

And I desperately want to know how it works.

But enough chit chat, the paper is entitled: “A break in mitochondrial endosymbiosis as a basis for inflammatory diseases.” (PMID: 38326590).

This thread will explain it in simple terms, but with nuance. 🧵👇

(link to more at the end)

Potentially of interest to:
@ChrisPalmerMD #BrainEnergy
@thegarybrecka @joerogan - Discussed Autoimmune Disease on Epi #2304. I agree with Gary, "God [metaphorically or literally speaking, depending on your beliefs], didn't make a mistake." And THIS might be what we are missing
@hubermanlab @R_Mohr @bryan_johnson because of relationship to circadian rhythms
@MitoPsychoBio because #mitochondria
@AdrianSotoMota @drmarkhyman @MatthewNehsMD @drericwestman @JEverettLearned @AKoutnik @lowcarbGP because I know they will
And Ht/ @davidludwigmd who passed me the paper that inspired this thread, newsletter & upcoming video
#autoimmunity #inflammation #mitochondria #metabolichealth #metabolism

2/6) What is "Mitochondrial Endosymbiosis?"

About 2 billion years ago, a cell consumed another, smaller bacteria-like cell (technically it was an Asgard archaeon). That second, smaller cell didn’t get digested and pooped out, but integrated into the larger one.

This is what’s meant by “endosymbiosis.”

And, you guessed it, that smaller cell was the precursor to our very own mitochondria, the engine and the powerhouse of most of the cells in your body and the center of your metabolism.

But your mitochondria are far more than just little engines.

They are also informational hubs and communication stations, signaling all over your body to cue and coordinate near infinite pathways and processes.

And how mitochondria do this derives, at least in part, from their foreign origins. Truly, mitochondria retain many of the signatures of their foreign origins that mark them much like bacteria or viruses and apart from other components of “you.”

The authors write, “we can also consider mitochondria as a pseudobacterium ‘bricked in’ behind the mitochondrial outer membrane.”

3/6) A Break in Endosymbiosis Triggers Autoimmunity

And your body’s immune system is great at recognizing the “other” – foreign invaders.

Mitochondria, for the most part, are shielded within cells and so don’t get targeted and attacked. However, the body can selectively release mitochondrial components or mitochondria-derived signaling molecules to trigger certain events.

In the authors’ words, “[T]he endosymbiotic origin of mitochondria marks them apart from the rest of the cell in a way that can be co-opted to produce key messages pertaining to cell fate.”

For example, in response to cell stress, mitochondria can release proteins from the intermembrane space, like cytochrome C, to trigger a form of organized cell death called apoptosis. Mitochondria also retain their very own mitochondrial DNA (mtDNA), separate from the DNA in your cells’ nuclei.

And the release of this DNA can also trigger immune reactions. In some cases, the inner portion of mitochondria can swell, and components can literally herniate out (illustrated below) of the mitochondria, pushing components including mtDNA, and triggering an immune/inflammatory reaction.

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Nick Norwitz

@nicknorwitz

Apr 7

🚨FINALLY! The Lean Mass Hyper-Responder 1 Year Data Just Dropped!🚨
jacc.org/doi/10.1016/j.…

🫀Most participants showed NO OR MINIMAL or progression of coronary plaque
🫀Neither ApoB nor LDL exposure predicted plaque progression
🫀But plaque predicted plaque progression, leading to the conclusion and Title:

1/10) 🧵This thread will give you some high-level points, direct you to more information, and tell you how 🫵YOU🫵 can help change “the science”

(🔗 links at the end!)

ht/ @realDaveFeldman @AdrianSotoMota @Metabolic_Mind @janellison @bschermd @BudoffMd @khurramn1

2/10) Necessary Background

Colleagues and I have spent the last several years studying what happens to cholesterol levels in people who adopt very low-carbohydrate ketogenic diets

🤔Most don’t see increases in cholesterol.

🤔Many even see decreases.

👉However, some see their LDL cholesterol (LDL-C) levels rise so high that most doctors think it’s “inconceivable.”

These special individuals are called ‘lean mass hyper-responders’ (LMHR) because they are, as a population, generally lean and healthy.

In fact, our prior meta-analysis of 41 human RCTs (PMID: 38237807) showed that the leaner a person is, the higher their LDL-C tends to rise on a low-carbohydrate diet trials.
🧈🧈🧈🧈This study also showed that having a BMI < 25 kg/m2 was >5X as powerful as being in the top quartile of saturated fat intake for predicting LDL-C change.

So, this is certainly far more interesting than a ‘blame-the-butter’ story …

3/10) We followed 100 LMHR and near- LMHR, having mean BMI 22.5 kg/m2 and mean LDL-C = 254 mg/dl, with high resolution coronary CT angiography.

We followed them to see whether, and to what degree, plaque accumulated in the arteries of these individuals with extremely high LDL-C.

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Nick Norwitz

@nicknorwitz

Apr 3

Why do some people with crazy high LDL-C and ApoB develop no plaque in their arteries, while others – including those with far lower LDL and lower ApoB – do develop plaque? 🫀🤔(link 🔗 at the end) 🧵...

1/6) We know this is a phenomenon. So, let’s tackle one possible explanation centered around the following term: Transcytosis...

#LDL #ApoB #LMHR #LEM #Cholesterol #HeartHealth #CholesterolCode cc @realDaveFeldman @AdrianSotoMota

2/6) Transcytosis, Made Simple🫀🤔
Your arteries are lined by cells called endothelial cells. Endo- means within, as these cells are within the tube that composes your blood vessels. A coronary plaque grows when cholesterol-containing particles, including LDL particles, slip through the endothelial barrier and begin to seed a plaque.

But HOW do cholesterol-containing particles penetrate the endothelial barrier? It’s not like a healthy endothelial barrier is coarse chicken wire. It’s rather tightly knit.
That’s where “transcytosis” comes into the picture.

Transcytosis is the process whereby a cell – in this case, the endothelial cells lining your arteries – sucks up something from outside (here, an LDL particle containing cholesterol), passes that something through its interior, and then out the other side.

By way of analogy, think of your artery wall like an exclusive nightclub. Some particles get waved in VIP-style. Others get stuck outside. But what if LDL wasn’t just passively slipping through a hole in the wall, but was actually being escorted through by a bouncer? That is - more or less - transcytosis.

3/6) Your Coronary Epiphany! 🫀💡
Now, given this perspective, you may have just made a connection or had a coronary epiphany!
People often talk about the process of plaque development in a manner that suggests the more cholesterol-containing particles you have in the blood, the more that end up getting inside your artery wall and getting trapped there – in a rather linear fashion.

Let me be clear, this idea that more cholesterol containing particles in your blood automatically equals more flow of these particles into your artery walls (and more coronary artery disease) is a MASSIVE ASSUMPTION and likely incorrect, or at least incomplete.

Instead, transcytosis is an active, regulated process...

Read 6 tweets

Nick Norwitz

@nicknorwitz

Mar 29

🧠Saffron for Depression: The Science, the Studies, and the Recipes🧠

1/5) What if I told you that the kitchen spice – Saffron – could treat depression?

It may sound too good to be true, but that claim is supported by a growing pile of human randomized controlled trials (RCTs) and sensible biological mechanisms.

I’m going to share two of these studies, explain the neuroscience, and direct you to more learning.

This golden spice really might be the next big thing in mental health!

References are in the newsletter linked at the end. #saffron #depression #mentalhealth

2/5) Saffron vs SSRI (RCT)
This double-blind randomized controlled trial compared 6 weeks of saffron supplementation (30mg/d) vs Prozac (fluoxetine), a commonly prescribed selective serotonin reuptake inhibitor (SSRI).

Impressively, the saffron performed equal to the fluoxetine!

You can see the results over 6 weeks here, with the Hamilton Rating Scale for Depression dropping in lock step between the treatments.

The absolute decrease in both treatments was >12. What does that number mean?

Well, in clinical trials, there’s a key distinction between a “statistically significant” difference and a “clinically significant” difference. A “statistically significant” difference means there was a detectable numeric difference, as in over time or between groups. Conversely, a “clinically significant” difference means that size of the change was detectable and meaningful for the patient.

Now while it’s somewhat arbitrary, a clinically meaningful change in this depression scale is ~5 points, which means a ~12-point drop is impressive and is clinically substantial!

Note on Side Effects: One presumed advantage of saffron is that it could have fewer side effects than prescription medications. In this first small pilot trial, there is an apparent trend to lower side effects in the saffron group vs SSRI. To see that table, click on the link at the end of this thread.

3/5) Saffron for Mental Health - Meta-Analysis
Rather than working through another 20+ studies, I want to share with you excerpts from a meta-analysis of 23 RCTs conducted on saffron for mental health, including depression and anxiety:
👉 [M] eta-analysis found a significant and large positive effect size for saffron reducing symptoms of depression in comparison with placebo.
👉When compared with antidepressants medications, there was no significant difference between saffron and medications.
👉Meta-analysis of studies that investigated the effect of saffron as an adjunct to pharmacotherapy reported a large significant benefit from saffron supplementation.

In simpler terms:
👉Saffron’s effect alone with large and positive for mental health
👉Saffron performed as well as commonly prescribed medications
👉Saffron provided additional benefit when stacked on prescription medications

Effects on anxiety were similar.

Read 5 tweets

Nick Norwitz

@nicknorwitz

Mar 28

Cold Exposure❄️, Omega-6 & Omega-3 🐟. Fats-cinating Research! Let’s dive in! (link at end)

1/5) In this study, 64 adults endured 2 hours of cold exposure near their shivering threshold.

🤔Results🤔

Massive changes in signaling lipids, including omega-6 and omega-3 fats and their derivatives, endocannabinoids and specific pro-resolving mediators.

On net, the changes reflected a signature of improved cardiometabolic health 🫀❤️‍🔥 #coldplunge #hearthealth

2/5) 🥶Some specific Omega-6 and 3 Changes🥶

👉39% Increase in the omega-6 oxylipin 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME). This oxylipin has been shown to increase the uptake of
fatty acids by brown fat and skeletal muscle.

🔥But even more impressive than the omega-6 response was the omega-3 response...

👉17 out of 17 omega-3 fats and their derivatives increased in the blood after cold exposure, by an average of 77%

👉The most prominent change, with an increase of 155%, was in 14- hydroxy-docosahexaenoic acid (14-HDoHE), which has been shown to inhibit activation of platelets involved in blood clots, increase blood flow, and inhibit inflammation.

👉And increases were noted in Resolvin D5, a powerful anti-inflammatory compound that inhibits the production of inflammatory molecules, like IL-6, reduces pain and protects various organs from inflammatory challenges.

3/5) And there were changes in endocannabinoids!🪴

There was an increase in anandamide, which binds the CB1 receptor – a key receptor involved in the effects of THC.

So, I’ll let you put 2+2 together on that... I’m not saying that a cold plunge will make you ‘high’ per se, but it’s an interesting mechanistic overlap… and one that overlaps with people’s experiences.

Read 5 tweets

Nick Norwitz

@nicknorwitz

Mar 22

☕️Coffee for Gut Health?! 🦠 New Research will have you Express-O-ing excitement!

This thread will reveal what new research in Nature Microbiology has discovered, tell you how much coffee to drink to get the health benefits, compare caffeinated vs. decaf, and more. I hope you’ve had a cup or two because you’ll need focus for this. (🔗link at the end)

1/8) Quick Background on the Health Benefits of Coffee

First, coffee intake has already been associated with lower mortality, reduced cardiovascular disease-related death, and a lower risk of type 2 diabetes. But nutritional epidemiology—the study of diet and health outcomes in large populations—has its limitations because it can only look for correlations.

To solidify coffee’s health halo, what we want is a complementary biological mechanism, a physiological story that helps it all make sense. #coffee #microbiome

2/8) Coffee Changes the Microbiome: Lawsonibacter asaccharolyticus

So, let’s introduce the protagonist of this story, a gut bacterium named Lawsonibacter asaccharolyticus. (I know, it sounds kind of like a Harry Potter spell.)

To discover the Lawsonibacter asaccharolyticus–coffee link, the researchers took information on food intake, including > 150 specific foods with associated and microbiome samples, then look for connections between specific foods and microbiome signatures.

☕️Among the >150 foods analyzed; coffee stood out for having the clearest microbiome signature.

3/8) For further analyses, they broke participants into three groups:
👉“Never” drinkers: Consumed less than three cups per month
👉“Moderate” drinkers: Consumed more than this but fewer than three cups per day
👉“High” drinkers: Consumed more than three cups per day

The strongest correlation between coffee consumption and the microbiome was Lawsonibacter asaccharolyticus. And—because I know you’re wondering, as I was when reading the paper—this association was independent of caffeine.

So yes, decaf counts!

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