Thread by @holmanm

1/ The pharma industry would have you believe that Statins are most beneficial in the early stages of Covid-19, so I guess they’re not going to fund any studies which contradict this theory. They would be shooting themselves in the foot. /2

https://twitter.com/SteveGPickering/status/1378956560110661633

2/ We know that Pandemic influenza infection causes increased oxidative stress, and that low levels of CoQ10 cause immune dysfunction. Statins interfere with the production of mevalonic acid, which is a precursor in the synthesis of Coenzyme Q10.

3/ Statins also act through the reversible block of the HMG-CoA reducing cholesterol synthesis and vitamin D production. Interventional and observational epidemiological studies show that vitamin D DEFICIENCY may confer INCREASED risk of influenza and respiratory tract infection

3/ We also know that lipoproteins including HDL, Chylomicrons, VLDL, and LDL can bind and neutralize LPS, Lipoteichoic acid, and VIRUSES, and can have an antiviral effect on RNA and DNA viruses by neutralizing them, regardless of whether they are enveloped or not.

3/ Dose-dependent 🔼 in glucose concentrations potentiate SARS-CoV-2 replication as well as ACE2 upregulation and cytokine production in monocytes suggesting 🔼 glucose as a principal promoter of virus replication & inflammatory response. Statins increase BG leading to T2D

4/ Sooo IMO We only get the truth from those who don’t have ‘skin in the game’ I encourage your comments !
bmj.com/content/368/bm…