Unfortunately there's misinformation circulating about this #HIV vaccine study. It's not mRNA but protein, and there's no expectation of efficacy - it's a possible first step on a long road toward persuading B cells to make protective antibodies scripps.edu/news-and-event… @IAVI
SARS-CoV-2 spike protein is readily vulnerable to neutralizing antibodies thankfully. But HIV Env protein has a protective cloak of sugar molecules, and mostly only weird-shaped antibodies produced by rare B cells can penetrate the cloak and neutralize HIV.
Inducing these weird antibodies with vaccines is a tough challenge, hence the lack of an effective #HIV vaccine. The @scrippsresearch @IAVI study is hopefully a first step toward boosting numbers of B cells that - with additional persuasion - can produce protective antibodies.
I think the confusion arose due to plans for future work with @moderna_tx to use mRNA to deliver this & other proteins. This is good news - hopefully will accelerate efforts to push B cells to take the remaining steps toward generating effective antibodies iavi.org/news-resources…
An additional error in the viral tweets circulating about this study is the statement that 97% of recipients developed antibodies against #HIV - *this wasn't measured.* Rather, it was the proportion of people in whom a certain type of B cell was detectable (see this fig from R4P)

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with TAGHIVscience

TAGHIVscience Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!