MOE: Phosphorus or Phosphate
πŸ‘‰ PROXIMAL Tubule: Main site for regulation of phosphate (some is reabsorbed with Na and H20; most is regulated by change in FGF23)
πŸ‘‰ DISTAL Tubule: Main site for regulation of calcium and potassium
#NKFClinicals #Nephpearls #CKDMBD ImageImageImage
Phosphorus bioavailability "varies" by source
#NKFClinicals #Nephpearls Image
Active Intestinal Phosphate Transport and Passive Intestinal Phosphate (Paracellular) Transport
πŸ“Œ Note that in these tight junctions, there are 5 groups of proteins that regulate this: occludens, claudins, JAMA, E-cadherin, desmosomes
#NKFClinicals #Nephpearls ImageImage
.@gchertow Hyperphosphatemia is bad
#NKFClinicals #Nephpearls ImageImageImage
WOLFE: Sources and "bioavailability" of dietary phosphate
#NKFClinicals #Nephpearls Image
WOLFE: Tenapanor (NHE3 inhibitor) causes an "intracellular acidemia" which leads to clamping down of the intracellular tight junction between 2 adjacent enterocytes so that phosphate is unable to readily pass paracellularly
PRO: BID dosing only; ⬇️FGF23
#NKFClinicals #Nephpearls ImageImageImage

β€’ β€’ β€’

Missing some Tweet in this thread? You can try to force a refresh
γ€€

Keep Current with Edgar V. Lerma πŸ‡΅πŸ‡­

Edgar V. Lerma πŸ‡΅πŸ‡­ Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @edgarvlermamd

12 Mar
Acute on Chronic Liver Failure ca. 2020 from @NEJM #Hepatorenal #Nephpearls

nejm.org/doi/full/10.10…
CONFIRM: In this trial involving adults w/ cirrhosis and HRS-1, terlipressin was more effective than placebo in improving renal function but was associated with serious adverse events, including respiratory failure (ca. 2021) #Hepatorenal #Nephpearls
nejm.org/doi/full/10.10…
Read 5 tweets
11 Mar
.@goKDIGO Controversies Conference on Home 🏑 Dialysis
#KDIGOHomeDialysis 🎧

πŸ‘‰πŸΌ kdigo.org/conferences/hd/ ImageImageImageImage
Unmet need in kidney failure treatment worldwide
#KDIGOHomeDialysis 🎧
#WorldKidneyDay
πŸ‘‰πŸΌ thelancet.com/journals/lance… ImageImage
Number of people getting KRT worldwide
#KDIGOHomeDialysis 🎧
#WorldKidneyDay
πŸ‘‰πŸΌ thelancet.com/journals/lance… ImageImage
Read 7 tweets
10 Mar
KALM-1: A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus ca. 2020 from @NEJM @sfishbane #Nephpearls
#VisualAbstract by @kidney_boy

nejm.org/doi/full/10.10…
International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis ca. 2017 from @CJASN @DOPPStudy @WMRenalN @DrMattGB @brurobinson1 #Nephpearls
πŸ‘‰ cjasn.asnjournals.org/content/12/12/…
RCT of Difelikefalin for Chronic Pruritus in Hemodialysis Patients ca. 2020 from @KIReports @sfishbane #Nephpearls
πŸ‘‰ kireports.org/article/S2468-…
Read 4 tweets
19 Sep 20
Who uses video conferencing? #HealthXPH πŸ‡΅πŸ‡­
πŸ‘‰πŸΌ addinfographic.com/video-conferen…
The rise of video conferencing #HealthXPHπŸ‡΅πŸ‡­
πŸ‘‰πŸΌ google.com/amp/s/technica…
Do’s and Dont’s of videoconferencing
#HealthXPHπŸ‡΅πŸ‡­
πŸ‘‰πŸΌ phnxaudio.com/blog/dos-and-d…
Read 6 tweets
16 Sep 20
Peritoneal Dialysis (PD) for AKI Treatment in the US: Brought to You by the #COVID19 Pandemic ca. 2020 from @ASNKidney360 @PD_Perls #CoronaKidney #Nephpearls
kidney360.asnjournals.org/content/kidney… ImageImageImageImage
Increasing Peritoneal Dialysis (PD) Use in Response to the #COVID19 Pandemic: Will It Go Viral? ca. 2020 from
@JASN_News @PD_Perls @EdwinaB23513542 #CoronaKidney #Nephpearls
jasn.asnjournals.org/content/jnephr… ImageImage
Acute Start Peritoneal Dialysis (PD) during the #COVID19
Pandemic: Outcomes and Experiences ca. 2020 from @JASN_News @osamaelshamy88 #CoronaKidney #Nephpearls
jasn.asnjournals.org/content/31/8/1… ImageImage
Read 10 tweets
4 Sep 20
Acute Hyperkalemia Webinar from @ISNkidneycare @goKDIGO #Nephpearls
Classification of acute hyperkalemia #Nephpearls
Prevalence of hyperkalemia #Nephpearls
Read 17 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!