Please be aware that out of 6.8M+ doses of the J&J vaccine that have been administered in the U.S., 6 cases of a rare & severe type of blood clot in individuals after receiving the vaccine have been reported. Right now, these adverse events appear to be extremely rare.
With this said, in the U.S., we have mRNA (Moderna & Pfizer) vaccines available so please do not let this deter you from getting vaccinated in the meantime. All 6 cases occurred among women between the ages of 18 and 48, and symptoms occurred 6 to 13 days after vaccination.
I want everyone to put this in perspective and try to process this rationally. 6 cases out of 6.8M+ doses administered (0.00000088). They’re looking into this out of an abundance of caution. You are MORE likely to suffer from blood clots from being infected with SARS-CoV-2.
Again, this is a PAUSE NOT A SUSPENSION so that the CDC/FDA may further investigate the issue, so please try not to panic. I know it’s difficult with headlines, mass hysteria, and antivaxx doubt but it’s important to process the context of the situation and remedy this now.
Based on the FDA/CDC conference call that was just held, it seems this pause was mostly to prepare administrators/clinicians to advise, diagnose, and treat recipients who MAY develop CVST and/or related conditions due to vaccination. They expect this pause to only be temporary!
The FDA Director specified part of the reason for the pause after only 6 cases out of 6.8M+ doses administered was to be able to prevent and advise against patients being treated with heparin based anticoagulants.

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More from @sailorrooscout

14 Apr
Preclinical data shows Moderna’s variant-specific booster vaccine candidates (mRNA-1273.351 and mRNA-1273.211) increase neutralizing titers against SARS-CoV-2 variants of concern. The data is absolutely stunning! Preprint can be found here:
biorxiv.org/content/10.110… ImageImageImage
mRNA-1273.351 encodes for the S protein found in the B.1.351 lineage and mRNA-1273.211 comprising a 1:1 mix of mRNA-1273 and mRNA-1273.351. Both vaccines were evaluated as a 2-dose primary series in mice.
mRNA-1273.351 was also evaluated as a booster dose in animals previously vaccinated with 2-doses of mRNA-1273. The results demonstrate that a primary vaccination series of mRNA-1273.351 was effective at increasing neutralizing antibody titers against the B.1.351 lineage, while
Read 5 tweets
10 Apr
Wanted to clear this up. First, please remember that vaccines are preventives and NOT cures. One can still contract the virus once vaccinated and as long as it prevents them from facing severe disease and worse, it is still doing what it is supposed to.
timesofisrael.com/real-world-isr…
Secondly, what is important to know about this study is that most infections were from B.1.1.7, with only 8 cases being B.1.351. After two doses, extremely high effectiveness against B.1.1.7 took effect. While they observed reduced effectiveness against B.1.351, they also saw it
did not spread in Israel. In other words, B.1.1.7 is keeping B.1.351 “in check” which is what a lot of scientists predicted months ago when these variants came onto the scene. This is a good thing. Why? We know the vaccines are HIGHLY effective against B.1.1.7
Read 6 tweets
8 Apr
Encouraging studies! 🧵
An analysis of cross-reactive viral binding and neutralization of emerging SARS-CoV-2 variants shows Novavax’s and Moderna’s vaccines elicit immune responses that are effective against variants B.1.429 (CA) and B.1.351 (S. Africa).
nejm.org/doi/full/10.10…
Patients previously infected with SARS-CoV-2 received Pfizer’s vaccine. Before vaccination, they had neutralizing activity against variants B.1.1.7 & P.1 but not B.1.351. AFTER one dose, neutralizing activity against ALL variants increased substantially!
nejm.org/doi/full/10.10…
Convalescent serum from those who recovered from an infection with SARS-CoV-2 variant B.1.351 showed potent neutralization of D614G (original), as well as variants B.1.351 (S. Africa) AND P.1 (Brazil). Booster vaccines may just seal the deal if needed!
nejm.org/doi/full/10.10…
Read 9 tweets
5 Apr
We know individuals who recover from SARS-CoV-2 infections develop effective T-cell immunity. A new study in Nature finds individuals are able to gain T-cell memory in the absence of a detectable infection simply from exposure!
nature.com/articles/s4146…
Here researchers reported virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts. Data showed that the memory CD4+ and CD8+ T cells of 94.44% and 83.33%, respectively, of the COVID-19 patients successfully underwent expansion.
Their results indicated that most of the recovered COVID-19 patients had developed effective T-cell memory pools against SARS-CoV-2 and their close contacts to a lesser degree. The proliferation capacity, size and quality of T-cell responses in close contacts were also readily
Read 6 tweets
2 Apr
According to the CDC, those who are fully vaccinated can travel “at low risk to themselves,” both within the United States and internationally, but they must continue to take precautions like wearing a mask in public, avoiding crowds, maintaining social distancing.
Vaccinated individuals do not need to get a coronavirus test before arriving in another country, unless required to do so by authorities at the destination, and they do not need to quarantine after returning to the United States unless required to do so by local jurisdictions.
Vaccinated travelers should have a negative result from a coronavirus test before boarding a flight back to the United States, and they should get tested against three to five days after their return home. The recommendations do not alter the guidelines for the unvaccinated.
Read 4 tweets
1 Apr
Fantastic news out of Pfizer this morning!

•91.3% vaccine efficacy observed against COVID-19, measured seven days through up to six months after the second dose

•100% effective in preventing COVID-19 cases in South Africa, where the B.1.351 lineage is prevalent!
Pfizer’s vaccine was 100% effective in preventing severe disease as defined by the U.S. Centers for Disease Control and Prevention and 95.3% effective in preventing severe disease as defined by the U.S. Food and Drug Administration. This is AMAZING.
pfizer.com/news/press-rel…
This does NOT mean the vaccine is only effective for 6 months. It means that at the 6 month mark this level of high protection is still present! Vaccine safety now evaluated in more than 44,000 participants 16 years of age and older, with more than 12,000 vaccinated participants
Read 6 tweets

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