Yesterday’s news: German agency connects AZ to risk of blood-clotting. Unscientific! They put everyone at risk! Today’s news: How brilliant UK doctor linked blood-clotting to AZ, rightly wanting to raise awareness of a risk. /1
theguardian.com/society/2021/a…
Now the thing is this: the doctor is brilliant. The work is worthwhile. And the German work is mentioned as “The German group had quite a lot of experience with this particular condition.” It’s not the scientists that messed up here. It’s the journalists. Sorry folks. /2
But besides the sheer frustration of a storyline changing so quickly, I think there’s a lesson to draw here: a lesson of how quickly Brexit established a boundary in the mind. /3
Leavers AND remainers empathised so quickly, so completely with “their” agency over ”other” agencies that the outcome could only be: our agency says no connection, so an agency that sees a connection must be unscientific. /4
Apparently nobody bothered to ask scientists working in the field. Regulators. To find out things like we read now “The German group had quite a lot of experience with this particular condition.” /5
But the thing that scares me most is that this distinction actually makes sense in a world that’s interconnected. The AZ risk is very low - so low that in most age groups vaccination with AZ has a thoroughly clear benefit. /6
And the availability of AZ is different in the UK and in Germany - which makes Germany’s more stringent limits rational. And it is then again rational for UK regulators to fear that this has some impact. So now we are in a circle of discrediting each other /7
Curiously, some people now say: it was never about the link. It was about the risk. This is from March 15 bbc.com/news/uk-563975…
I should add one additional consideration: this automatic identification with “your” side is entirely normal - and trade people can tell you a lot about it. Some examples:
Take GIs. Italians consider it a fundamental rule of justice that only Parmesan from the right region is Parmesan. Anything else might be cheese. It’s not parmesan. Americans, with similar conviction, say that that is wrong.
Europeans love their precautionary principle. Anything else is sheer insanity and way too risky. Americans hate it and regard it as unscientific.
Beer and the German Reinheitsgebot. Who has the best plug. Etc. etc. It was, maybe, just a matter of time...
I did not think it was necessary, but apparently it always is: I am decidedly not criticising the UK vaccine rollout. I am a big fan of how it is going. And also very happy about it.

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More from @hhesterm

7 Apr
What if - hear me out - what if each regulator is deciding against the backdrop of its own country. Almost as if the German regulator decides for Germany and the UK one for the UK? Let's look at this - surprising - hypothesis /1
The UK program relies on AZ to a large extent. It does have other vaccines, though. So - following our hypothesis - it will be cautious replacing AZ, it will do so to a more limited extent.
Germany does not get that much AZ, because AZ delivers 1/3 of the originally scheduled deliveries. For a doze of AZ it has 3 of Pfizer. Accordingly it can "limit" the AZ recommendation more - because that still means that 100% of the AZ delivered will be used.
Read 6 tweets
6 Apr
A Brexit and regulator thread - but it’ll take a bit. Stay with me (thread)
Consider regulators in the EU and the US for starters. You can do this with food or with drugs. /2
Rarely have I met an EU citizen who travels in the US and worries about food safety there or the other way around. And the same applies to drugs. /3
Read 8 tweets
3 Apr
Complex research in the western world is - more often than not - a collaborative effort also when it comes to financing. To pretend this is not the case puts research at risk. Here are the funders of the Jenner Institute, the Oxford vaccine innovaters.
Not every funder is involved in every project. CEPI, though, was a major funder of Oxford/AZ Covid work.
Read 4 tweets
2 Apr
I have had enough of the debate about vaccines turning into nationalist fighting. So some comments about where to go from here (thread)
Of course, the chart would be read in the context of the AZ wars. Its importance in this regard is somewhat limited, though. /2
You can still have a debate on how to read the various contracts etc. The one line that is problematic is that any one country deserve a first shot at the vaccine because it invested more. The truth is: collaboration.
Read 7 tweets
28 Mar
Always astonished by human capacity for mental exaggeration. Just take a look at the journey of public opinion on the UK. Starting point "a very competent country". (thread)
During the Brexit campaign, politics became disconnected from the civil service and some... let's say extraordinary things were said and done. At first people thought there must be a secret plan - precisely because of the amount of respect for competency.
But there was no secret plan. Suddenly people started to think "are we fundamentally incompetent? What is wrong with us?".
Read 8 tweets
27 Mar
Allow me to tell you a short story of pharma patents in world trade. The story start in the old days of GATT. Where patents were decidedly not part of world trade law (thread)
In those old days, it was a decision of each country whether to grant patents or not. Each country had to think "will this be a good choice for us? an incentive for research? Or actually counterproductive exclusivity?"
But in some developing countries this was perceived as unfair. In the US some thought "we pay higher prices for innovation. You just get it for free". Pharma patents were central to the debate.
Read 13 tweets

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