I saw this paper linked by @BioLayne (hat tip!) in a twitter discussion and had to stop and read most of it. Basically SFA vs PUFA infused muffin RCT. There's quite a lot of interesting data within. And it's publicly available, btw (no firewall)...
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
... The lipid profile changes for the SFA group are unsurprising to me, ofc. But I was surprised they went with ALT as the proxy for "liver fat accumulation". Relative change 53%, but I didn't find the absolute values listed for ALT between groups? Maybe in the supplement...?
... They had a subgroup of 10 (5 of each) where the did PET-MRIs (need more of this in studies) to detect "change in hepatic palmitate uptake" -- which tends to be a stronger proxy for liver fat accumulation, but it showed no association.
... Lots of great data on serum levels ceramides, sphingolipids, and sphingomyelin species.
And whether you come to the same conclusions the authors did, I definitely think it's worth the read.
(*Some things in this paper that we may be citing for the #LipidEnergyModel)
And whether you come to the same conclusions the authors did, I definitely think it's worth the read.
(*Some things in this paper that we may be citing for the #LipidEnergyModel)
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