Many thanks ⁦@chucktodd⁩ for hosting me on ⁦@MeetThePress⁩ with ⁦@ellisonbarber⁩ discussing how we navigate issues around JnJ vaccine and urgency to vaccinate ahead of an accelerating B.1.1.7 variant
Presumably the pause is to compare notes with European and UK regulators for both adenovirus vectored vaccines AZOx and JnJ. I said possible outcome would be if we could identify a specific at risk population say premenopausal women with a second risk factor such as BC, smoking
Then in this case we could redirect JnJ away from this group. I also stated more philosophically that this is a predictable consequence of only focusing on innovative vaccine technologies. We made some great vaccines but introduced some unnecessary risks and as a consequence..
We have two mRNA vaccines which are great vaccines but can’t be scaled to produce to 5 billion doses needed for LMICs, or adenovirus vectored vaccines which were never scaled and now difficult to navigate these safety flares. We needed more “old school” recomb protein vaccines..
Our vaccine being scaled in India to 1.2 billion doses , but we need US Govt to take more ownership and help us make another 3-4 billion doses.

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More from @PeterHotez

18 Apr
A reason, when virus transmission is still high and especially with B.1.1.7 variant, I typically wear a mask in public or when with others. As we head towards greater vaccine coverage in US about 75% by June, transmission will slow and masks less essential cnn.com/2021/04/14/hea…
The way I see this unfolding: as we advance towards high vaccine coverage of adults and adolescents by summer virus transmission will finally decrease substantially and then vaccinated individuals can feel much safer without masks. But we’ll still need to be mindful...
We should be prepared for the possible seasonality of COVID19 so that in January 2022 we might need to re-mask for a period of a few weeks if transmission goes back up. It requires our situational awareness and following CDC public health recommendations and guidance
Read 4 tweets
16 Apr
1/3: Even when US donates excess doses, it will still be a drop in the bucket: we need 4-5 billion vaccine doses for 1.1 billion people in SubSaharan Africa, 650 million in Latin America, 500 million low income Asian countries, there’s a better solution... washingtonpost.com/world/2021/04/…
2/3: With Bio E in India, our low cost @TexasChildrens Baylor Vaccine is being scaled for 1.2 billion doses. We could work with US Govt to produce another 3 billion doses, this is a high expressing Pichia yeast recombprotein vaccine similar to hepatitis B vaccine used for decades
3/3: our CoV vaccine program was initially supported by NIAID NIH and for COVID19 through Kleberg, Tito’s, JPB Foundations. Expanding manufacturing, producing the 4-5 billion doses of a vaccine first developed here in Texas would = great vaccine diplomacy win for US Govt world
Read 4 tweets
16 Apr
Apologies for disappointing you, my inbox is flooded with medical advice queries: I could answer them 24/7 and still not get to all of them. Honestly I’m not sure what to do, literally dozens every day, and each one requires thought, most provide incomplete information.
Instead I try to go on as many grand round lectures, podcasts, radio call in shows as I can. Usually 4-5 per day, and I still have the lab meetings, and cable news interviews. Most days I’m up at 4:30 AM, asleep by 10:30 PM, a couple of extra hrs on weekends. Like this for 16 mos
In between, hundreds of emails to answer or triage. Many wonderful expressions of kindness, which mean a lot to me. But equal filled with hate and evil, especially from Q gang. Those are especially demoralizing, and they set me back. Sometimes I pause until my darkness lifts, or
Read 4 tweets
14 Apr
Many thanks ⁦@KatyOnMSNBC⁩ ⁦@KatyTurNBC⁩ for hosting me, as I reported on the rationale for J&J pause, and using this period to see if additional cases of cerebral thromboses have occurred, whether it’s an issue with all adenovirus vectored vaccines: JnJ AZOx Sputnik
Some additional points...
First, possibly 10-15 years ago no one in US would have questioned a pause, but now we have an aggressive antivaccine movement in US + weaponized health communication from Russia discrediting Western vaccines. US Govt has refused to launch a counteroffensive and created a monster
Read 5 tweets
14 Apr
My best guess is that the recent heightened antiscience antivaccine aggression targeting Me, Tony, Vivek and deliberate twisting we see nightly on Fox News programming has little to do with any particular anchor. It’s an executive decision from higher ups thedailybeast.com/tucker-carlson…
Why the Murdoch gang wishes to go in this direction and work against American interests is unclear to me, I could guess on the basis of ratings competition, need to rebrand, create new think-tank identity around discredited ideas or pseudoscience, caving to foreign influence?
All conjecture until someone internally comes forward
Read 5 tweets
13 Apr
Many thanks ⁦@tomkeene⁩ ⁦@FerroTV⁩ ⁦@lisaabramowicz1⁩ for hosting me on ⁦@BloombergTV⁩ discussing events with JnJ vaccine why it’s on hold and the possible mechanisms of blood clots from adenovirus vectored vaccines, JnJ, AZOx, we don’t know about Russian
Based on AZOX another adenovirus vaccine, this class of replication deficient viral vectored vaccines can stimulate anti PF4 antibodies. PF4 found in platelet granules. This activated platelets, causes platelets consumption, and then thrombotic thrombocytopenia.
Rates about 1 per 100,000 to 200,000 for AZOx, 1 per million for JnJ, we don’t know about Russian adenovirus vaccine since it bypasses stringent regulatory authorities
Read 5 tweets

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