Thread by @MonicaGandhi9

This is true but I am VERY worried about India right now. My understanding is that vaccine capacity is not maximal because more raw materials are needed. India has called on the Biden Administration (ASlavitt) for help. Masks/distancing as much as possible in crowded conditions.

https://twitter.com/bykerseven/status/1384562520057384960

India has Covishield (AZ vaccine) + Covaxin (Bharat Pharm). I see from phase I/II trial of the Covaxin vaccine that cell-mediated responses were generated (although used IFN-gamma assay that Sputnik V used in their paper instead of direct measurement).
medrxiv.org/content/10.110…

However, reason worried about Covaxin is that we have not seen phase 3 clinical trial results yet except in press release; would love to see peer reviewed publication (does anyone know status?). Covaxin is a whole inactivated viral vaccine like Sinovac
economist.com/graphic-detail…

Sinovac underperforms (50% efficacy) & so cannot be vaccine for world. Covaxin press release is only interim results (not full) of phase 3 trial: 25,800 participants between 18-98 years of age, including 2,433> 60 & 4,500 with comorbidities.
bharatbiotech.com/images/press/c…

Primary endpoint based on 1st occurrence of PCR-confirmed symptomatic (mild, moderate, or severe)
COVID occurring 14 days after 2nd shot. 1st interim analysis based on 43 cases only, 36 in placebo, so vaccine efficacy 80.6% with this interim data. Can someone tell me what %

population being vaccinated with Covaxin (whole inactivated) versus Covishield (AZ, adenovirus/DNA vaccine). India huge country so my questions are:
1) Is Covaxin adequate: what are full phase 3 results? Sinovac disappointing & same type
2) mRNA vaccines to India right away?

I wrote company (Bharat) some time ago to ask for fuller details on Covaxin efficacy against severe disease and death but they said wait for full peer reviewed pub. Does anyone know? And would certainly consider using spike protein vax in meantime; need world help