A misleading headline
No question about the profound crisis in India but to ascribe it to B.1.617, a variant of interest, in inaccurate,
It's not a "double mutant"—there are 13 mutations /1
No question about the profound crisis in India but to ascribe it to B.1.617, a variant of interest, in inaccurate,
It's not a "double mutant"—there are 13 mutations /1
2 other major variants, B.1.351 (SA)and B.1.1.7 (UK), are circulating (graph via @trvrb) See his🧵
https://twitter.com/trvrb/status/1385660979124400134"It's hard for me to infer the degree to which new variants are driving the surge in cases in India" /2
The 3 key spike mutations in B.1.617
E484Q is unlikely to be of consequence
cell.com/cell-host-micr…
L452R is shared with CA variant; it has some but not very high level of immune evasion
P681R in many other variants, of uncertain significance /3
E484Q is unlikely to be of consequence
cell.com/cell-host-micr…
L452R is shared with CA variant; it has some but not very high level of immune evasion
P681R in many other variants, of uncertain significance /3
Other good news: Recent lab studies indicate vaccine's ability to neutralize B.1.617, as expected from its structure economictimes.indiatimes.com/industry/healt… /4
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