1/ How does monkeypox spread? #MedTwitter
Through close, personal, contact:
•Direct contact with monkeypox rash, scabs, or body fluids
•Touching objects, fabrics (clothing, bedding, towels) used by someone with monkeypox.
•Contact with respiratory secretions
2/ PPE to prevent monkeypox transmission
Healthcare workers: gloves, gowns, mask and eye protection.
N95/respirators for activity that involves aerosol generation
Patients: Keep lesions covered and wear a mask when around others
3/ To control monkeypox we urgently need
a) Testing, testing, testing!!
Early ID means that
⁃isolation can be implemented and further transmission prevented
⁃Ring vaccination of contacts can prevent illness in contacts
3/ if you meet one or more criteria, you should seek out one of the following treatments in order of preference
⁃Paxlovid
⁃Remedesivir IV for 3 days
⁃Monoclonal antibody (Bebtelovimab)
⁃Molnupiravir
COVID cases in India rising rapidly, heralding a probable third wave. While India needs to prepare for the worst, there are hopeful signs that this wave will not be associated with the high death rate of the delta wave
Why?
1/
Two main reasons
- Larger proportion of the population immune through vaccination or past infection
- Omicron does not cause the severe lung inflammation and oxygen need seen with delta
2/
What can an individual do to prepare:
- Get vaccinated, get boosted when eligible
- Mask up
- Avoid crowds whenever possible
3/
What we know and don't know about #Omicron (B 1.1.529)
1/ Reported in S. Africa Nov 24 from a sample from Nov 9. So it has been around for at least 3 weeks, possibly longer.
2/ Classified as Variant of Concern (VOC) on Nov 26
3/ Several mutations on the spike protein
4/ As of Nov 27, found in many other countries including Belgium, Botswana, Germany, Hong Kong, Israel, Italy, UK.
Seems widespread already.
5/ Why is it Omicron a variant of concern ?
First, it has spread rapidly in S. Africa, replacing Delta entirely in some areas. This ability to replace delta is striking because other variants have not been able to do that.