1/5 It is very, very hard to explain how utterly disreputable the lipid hypothesis is. All of this angst about increased LDL-C and/or apoB counts on LC diets is based on the assumption that somewhere, somehow, cholesterol is the cause of heart disease. How LDL-C invades"
2/5 (by active and controlled transcytosis!) the sub-endothelial space, disappears from there and then suddenly appears at over 200 micrometres deeper, with none showing in the intervening zone requires a belief tenet which bears no resemblance to reality...
3/5 No one would reasonably doubt that the lipid deep down at the intima/media junction level comes from lipoproteins (though there are other plausible explanations). No one would doubt that loading the lipoproteins with with Linoleic acid is likely to be a Bad thing.
4/5 No one would doubt that generating oxidative derivatives of the lipids in those lipoproteins might be a Bad Thing.
But trans-endothelial "invasion" is beyond belief.
This would suggest that all Lipidologists are talking crap.
Nothing new there then.
But trans-endothelial "invasion" is beyond belief.
This would suggest that all Lipidologists are talking crap.
Nothing new there then.
5/5 This was bollocks in the 1950s. My question is, as always, at what time did it stop being bollocks? ---
Petro Dobromylskyj,
Petro Dobromylskyj,
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