Body composition, which is the relative proportion of muscle to body fat, rules health.

Metabolic syndrome and type 2 diabetes, are closely linked to body composition.

Thread 👇
526 apparently healthy adults were grouped in tertiles (equal thirds) of muscle/fat ratio (MFR), from highest to lowest.

Those with lowest MFR had 5.4 times the odds of metabolic syndrome. Image
Metabolic syndrome and insulin resistance are linked, and vary with ethnicity, but this variation is almost if not entirely due to variation in muscle/fat ratio. pubmed.ncbi.nlm.nih.gov/19820012/
Aging and insulin resistance are also linked, but this has almost nothing to do with aging per se, but to percent body fat. pubmed.ncbi.nlm.nih.gov/1400882/
There's no difference in insulin sensitivity between young and old when matched for being athletes, normal weight, or obese.

Age has nothing to do with it: body composition and fitness rule. Image
Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. ncbi.nlm.nih.gov/pmc/articles/P…
Obese people have greater whole-body insulin resistance, but this is due to low ratio of muscle to body fat. academic.oup.com/jcem/article/8…
Low cardiorespiratory fitness is linked to impaired insulin sensitivity and "was the most prevalent abnormality in a population at risk for IRS and T2DM but without overt disease."

You know what to do: get fit.
pubmed.ncbi.nlm.nih.gov/19825145/
A single bout of high-intensity, glycogen-depleting exercise improves insulin sensitivity. diabetes.diabetesjournals.org/content/36/4/4…
Resistance training is more effective than endurance training for improving insulin sensitivity and body composition.

Resistance training is just much harder and produces a higher level of metabolic stress. ncbi.nlm.nih.gov/pmc/articles/P…
Resistance training can increase muscle mass and decrease visceral fat, and therefore massively decrease your risk of metabolic syndrome, T2D, and chronic disease.

And of course, a diet of real whole foods, low in refined carbs.
More muscle mass and less body fat are keys to health.

Health authorities often focus on the body fat, but pay less attention to muscle.

Lift weights and eat real (not ultra-processed) food.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with P. D. Mangan Health & Fitness Maximalist 🇺🇸

P. D. Mangan Health & Fitness Maximalist 🇺🇸 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Mangan150

24 Mar
Why exercise is ineffective for weight loss

Thread 👇
Burning calories

Exercise doesn't burn as many calories as most people think.

A 5-mile run, which is a considerable amount of exercise, burns about 500 calories.

But that's only 400 more calories than if you just sat on your backside doing nothing.
You'd need to run ~35 miles to lose one pound of body fat, assuming you ate no more than if you hadn't run 35 miles.

Surely there must be a better way.
Read 10 tweets
17 Mar
Resistance training, aka strength training or lifting weights

Crucial for health and aging well.

Why?

Thread 👇
Resistance training builds muscle, and muscle is an underappreciated factor in health

"altered muscle metabolism plays a key role in the genesis, and therefore the prevention, of many common pathologic conditions and chronic diseases"

academic.oup.com/ajcn/article/8…
Aging is associated with loss of muscle.

Use it or lose it.

A large portion of the decline in cardiovascular fitness (VO2max) with age can be attributed to muscle loss. journals.physiology.org/doi/abs/10.115…
Read 17 tweets
16 Mar
High-dose aspirin for 2 weeks in type 2 diabetics dropped glucose from 190 to 92. All patients responded.

Indicates that inflammation is important in insulin resistance.

jci.org/articles/view/…
Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

Could be the (or one) source of inflammation. LPS come from gut bacteria so could indicate leaky gut as the source.

nature.com/articles/ijo20…
Read 4 tweets
13 Mar
Metabolic syndrome massively increases the risks for chronic disease.

What is it and why should you care?

Thread 👇
Someone has metabolic syndrome when they have at least 3 of the following 5 markers:

⬆️waist size
⬆️blood glucose
⬆️triglycerides
⬆️blood pressure
⬇️HDL cholesterol

Any 3 of those = metabolic syndrome

Any 1 = not 100% healthy

Metabolic syndrome is highly linked to obesity.
Metabolic syndrome is related to insulin resistance.

A classic study showed that people in the lowest third of insulin resistance had zero cases of heart disease, cancer, strokes etc.

Most were in the highest third.

Staying healthy means avoiding metabolic syndrome
Read 14 tweets
11 Mar
Industrial seed oils, aka vegetable oils, are still widely recommended as healthy.

But are they?

Thread 👇
Vegetable oils include a number of common cooking and dressing oils:

*canola
*soybean
*corn
*safflower
*sunflower
*and others

Note that they're not made from vegetables, but from seeds via an industrial process.

Olive and avocado oils are fruit, not seed, oils.
Until the late 19th century, these oils barely existed, and humans did not consume them.

But somebody got the bright idea of pressing the oil from cottonseeds, previously just a waste product.

Seed oils were born.
Read 14 tweets
9 Mar
Meat: does it harm your health

or is it in reality a superfood?

Let's take a look at the evidence.

Thread 👇
Everyone "knows" that meat is not healthy, but until a few decades ago, no one ever thought that.

Something changed.
What changed was the demonization of saturated fat as a cause of coronary heart disease by the (now notorious) Ancel Keys.

He used observational and cherry-picked data to "prove" his hypothesis.
Read 16 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!