Just published @ScienceMagazine
"After one dose, individuals with *prior infection* showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351." 👍
These findings are important to reinforce 2 points:
1. People with prior covid infections benefit from vaccination
2. Lack of evidence that a 2nd dose is necessary for confirmed prior covid
"second dose vaccination... post infection individuals offers no additional enhancement"
Other points:
3. Prior covid + 1 dose appears to be more protective than no prior covid + 2 doses, vaccines "skewed" to Ab response
4. 4-fold T-cell response to infection
5. "Large protective margin" vs B.1.351 (SA), the variant w/ most immune evasion
Independent replication of the prior covid + 1 vaccine dose protection against all major variants
medrxiv.org/content/10.110… by @TheTafesseLab @OHSUNews @OHSUSOM
People who’ve had covid are a significant group among those not getting vaccinating. But these data show remarkable added benefit of 1 vaccine dose —> super-natural protection.

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More from @EricTopol

29 Apr
Confirmed Prior Covid + 1 shot mRNA vaccine = Fully Vaccinated (FV).
Strong evidence to support👇
But many people w/prior covid are getting 2nd dose, unnecessary side effects
CDC/gov't needs to certify this for international travel and other FV activities
May even be better than 2 doses nejm.org/doi/full/10.10…
More on unnecessary side effects and action vs variants

Read 4 tweets
29 Apr
And it’s about time
More from @POTUS speech on vaccinations
A dose of hope
We can't let our guard down
"the @NIH, I believe, should create an advanced research project agency for health"
Read 4 tweets
28 Apr
The most impressive US accomplishment of the 1st 100 @POTUS days is having built a wall to fend off a major B.1.1.7 strain surge. Vaccine immunity in >140 million people provided the requisite defense against this more formidable version of the virus.
It will be remembered as an extraordinary time when Americans came together to vaccinate up to 4.6 million people in a day, with tens of thousands of volunteers helping to get one another protected
Now for the 1st time the goal of containment is in sight, which will be harder, getting tens of million more vaccinated with incentives, education & taking on the aggressive anti-vaxx movement
And the vital need to turn outward, to help the rest of the world build a similar wall
Read 4 tweets
27 Apr
An exceptionally important perspective on the anti-vaccine empire, by @PeterHotez @nature today
The need for a counteroffensive to hundreds of websites, ~58 million social media followers, influential groups, Russia-sponsored disinformation to defeat covid
Peter is so spot on here:
Read 4 tweets
25 Apr
In 2020, T cells were largely ignored w/r to covid infections.
In 2021, T cells are being largely ignored w/t to covid vaccinations.
In part, because they are rarely assessed.
A review of some recent studies /1
Lack of effect of variants on T-cell responses /2
The strong vaccine-induced T-cell response in people with prior covid @TheLancet
thelancet.com/journals/lance… /3
Read 6 tweets
24 Apr
A misleading headline
No question about the profound crisis in India but to ascribe it to B.1.617, a variant of interest, in inaccurate,
It's not a "double mutant"—there are 13 mutations /1
2 other major variants, B.1.351 (SA)and B.1.1.7 (UK), are circulating (graph via @trvrb) See his🧵
"It's hard for me to infer the degree to which new variants are driving the surge in cases in India" /2
The 3 key spike mutations in B.1.617
E484Q is unlikely to be of consequence
L452R is shared with CA variant; it has some but not very high level of immune evasion
P681R in many other variants, of uncertain significance /3
Read 5 tweets

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