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Eric Topol Profile picture
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1 May, 4 tweets, 2 min read
What may we expect from vaccination of 10-15% more of the US population?
7-day averages compared with UK and Israel shows a 5-15X difference in outcomes
Adding 2nd dose vaccination rates
Graphs of the data show the inter-country vaccine-outcomes gradient
@OurWorldInData
0.1%. Attainable.

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More from @EricTopol

Eric Topol Profile picture
2 May
We are fortunate that vaccines induce such a strong immune response and provide protection from all of the virus variants that have evolved to date Image
Case in point
Had our vaccines not been protective vs B.1.1.7 (UK), the variant with >50% increased transmissibility and increased lethality, the country, w/ >147 million vaccinated, would not look like this right now
wsj.com/articles/u-k-c… @Brabbott42 ImageImageImageImage
Another real world evidence case in point
Brazil's success vs P.1 in decreasing morality with Sinovac and Astra-Zeneca vaccines
medrxiv.org/content/10.110… ImageImage
Read 4 tweets
Eric Topol Profile picture
30 Apr
Just published @ScienceMagazine
"After one dose, individuals with *prior infection* showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351." 👍
science.sciencemag.org/content/early/…
These findings are important to reinforce 2 points:
1. People with prior covid infections benefit from vaccination
2. Lack of evidence that a 2nd dose is necessary for confirmed prior covid
"second dose vaccination... post infection individuals offers no additional enhancement"
Other points:
3. Prior covid + 1 dose appears to be more protective than no prior covid + 2 doses, vaccines "skewed" to Ab response
4. 4-fold T-cell response to infection
5. "Large protective margin" vs B.1.351 (SA), the variant w/ most immune evasion
Read 5 tweets
Eric Topol Profile picture
29 Apr
Confirmed Prior Covid + 1 shot mRNA vaccine = Fully Vaccinated (FV).
Strong evidence to support👇
But many people w/prior covid are getting 2nd dose, unnecessary side effects
CDC/gov't needs to certify this for international travel and other FV activities
May even be better than 2 doses nejm.org/doi/full/10.10…
More on unnecessary side effects and action vs variants

nejm.org/doi/full/10.10…
Read 4 tweets
Eric Topol Profile picture
29 Apr
And it’s about time
More from @POTUS speech on vaccinations
A dose of hope
We can't let our guard down
"the @NIH, I believe, should create an advanced research project agency for health"
Read 4 tweets
Eric Topol Profile picture
28 Apr
The most impressive US accomplishment of the 1st 100 @POTUS days is having built a wall to fend off a major B.1.1.7 strain surge. Vaccine immunity in >140 million people provided the requisite defense against this more formidable version of the virus.
It will be remembered as an extraordinary time when Americans came together to vaccinate up to 4.6 million people in a day, with tens of thousands of volunteers helping to get one another protected
Now for the 1st time the goal of containment is in sight, which will be harder, getting tens of million more vaccinated with incentives, education & taking on the aggressive anti-vaxx movement
And the vital need to turn outward, to help the rest of the world build a similar wall
Read 4 tweets
Eric Topol Profile picture
27 Apr
An exceptionally important perspective on the anti-vaccine empire, by @PeterHotez @nature today
nature.com/articles/d4158…
The need for a counteroffensive to hundreds of websites, ~58 million social media followers, influential groups, Russia-sponsored disinformation to defeat covid
Peter is so spot on here:
Here's a flagrant example from Russia's @sputnikvaccine broken down by @CT_Bergstrom cc @Kasparov63
Read 4 tweets

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