Eric Feigl-Ding Profile picture
May 3, 2021 21 tweets 6 min read Read on X
Sobering—“It is already clear that the virus is changing too quickly, new variants are spreading too easily & vaccination is proceeding too slowly for herd immunity to be within reach anytime soon.”

➡️ Vaccine hesitancy hurts public health.🧵 #COVID19
nytimes.com/2021/05/03/hea…
2) I don’t like this— “daily vaccination rates are slipping, and there is widespread consensus among scientists and public health experts that the herd immunity threshold is not attainable — at least not in the foreseeable future, and perhaps not ever.”
3) “rather than making a long-promised exit, the virus will most likely become a manageable threat that will continue to circulate in US for years to come, still causing hospitalizations and deaths but in much smaller numbers.”

➡️I don’t like waving this surrender flag.
4) “Continued immunizations, especially for people at highest risk because of age, exposure or health status, will be crucial to limiting the severity of outbreaks, if not their frequency, experts believe.
5) “The virus is unlikely to go away,” said Rustom Antia, an evolutionary biologist at Emory University in Atlanta. “But we want to do all we can to check that it’s likely to become a mild infection.”

➡️No, I think we can do better with #ZeroCovid approach.
6) “The shift in outlook presents a new challenge for public health authorities. The drive for herd immunity — by the summer, some experts once thought possible — captured the imagination of large segments of the public.”

➡️putting all eggs into vaccine basket inadequate.
7) “To say the goal will not be attained adds another “why bother” to the list of reasons that vaccine skeptics use to avoid being inoculated.”

➡️ INDEED—this is why this “vaccine savior” singular push is tricky to communicate. We need both vaccines & #ZeroCovid approach.
8) “People were getting confused and thinking you’re never going to get the infections down until you reach this mystical level of herd immunity, whatever that number is,” Fauci said.
“That’s why we stopped using herd immunity in the classic sense,” he added.
9) Fauci: “I’m saying: Forget that for a second. You vaccinate enough people, the infections are going to go down.”

➡️ My take: This is true, but “down” for some (India and Brazil) is not adequately down for others. “Down” is too subjective. And allows authoritarians to dismiss.
10) HERD IS A MOVING TARGET: “Early on, the target herd immunity threshold was estimated to be about 60 to 70 percent of the population. Most experts, including Dr. Fauci, expected that the United States would be able to reach it once vaccines were available.
11) “But as vaccines were developed and distribution ramped up through the winter and into the spring, estimates of the threshold began to rise. That is because the initial calculations were based on the contagiousness of the original version of the virus…
12) “The predominant variant now circulating in the United States, called B.1.1.7 and first identified in Britain, is about 60 percent more transmissible.
As a result, experts now calculate the herd immunity threshold to be at least 80 percent…”

MY TAKE: likely 80-90% for #P1.
13) “If even more contagious variants develop, or if scientists find that immunized people can still transmit the virus, the calculation will have to be revised upward again.”

My take➡️ we need to get serious that we need both vaccines and a #ZeroCovid mitigation approach.
14) At this point, all creative approaches to get people to vaccinate are on the table… even comedy…
15) “How insulated a particular region is from the coronavirus depends on a dizzying array of factors.
Herd immunity can fluctuate with “population crowding, human behavior, sanitation and all sorts of other things,” said Dr. David M. Morens, a senior adviser to Dr. Fauci.
16) “The herd immunity for a wealthy neighborhood might be X, then you go into a crowded neighborhood one block away and it’s 10X.”
Given the degree of movement, a small wave in a region with a low vaccination level can easily spill over into where a majority of is protected.
17) “At the same time, the connectivity between countries, particularly as travel restrictions ease, emphasizes the urgency of protecting not just Americans but everyone in the world, said Natalie E. Dean. Any variants that arise in the world will eventually reach the US.” ⚠️
18) Let me repeat: •Any variants that arise in the world will eventually reach the United States”!

➡️So damnit, those living in cushy bubbles in Manhattan who think we don’t have to worry about 🇧🇷#P1 or 🇮🇳 #B1617 variants coming to the US (you know who you are!)—wake up!
19) The only one thing that annoys me as much as anti-mask/anti-vax people are those who are “don’t worry about variants / vaccines will solve it soon” folks who dismiss the seriousness of variants & and foolishly think #COVID19 is over in US. It’s not!

nytimes.com/2021/05/03/hea…
20) Also, #P1 is rising across many parts of the US, hence we need to vaccinate more than ever.
21) Unvaccinated people need to stop thinking they are invulnerable.

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More from @DrEricDing

Feb 21
Woke or biology? There are actually more than the basic “male” XY & “female” XX sexes. Why? Because biology also creates people with single X chromosomes, or extra chromosomes like XXX, XXY, XYY, or XXX+, plus many 🧬genes. 👉All I’m asking is— please be kind to others. Thanks🙏 Image
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2) “The most frequent SCAs include Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Trisomy X syndrome (47,XXX), and Double Y syndrome (47,XYY).”

pmc.ncbi.nlm.nih.gov/articles/PMC10…
3) “The phenotype seen in SCAs is highly variable and may not merely be due to the direct genomic imbalance from altered sex chromosome gene dosage but also due to additive alterations in gene networks and regulatory pathways across the genome as well as individual genetic modifiers.”
Read 5 tweets
Feb 16
I'm shocked a lot of doctors don't know about this newer flu antiviral drug called Baloxavir (XOFLUZA)... that shortens your flu illness by 33%, and reduces your viral load by day 2, versus what a placebo takes 5-6 days to achieve. Baloxavir also seems superior to TAMIFLU (oseltamivir) for smashing your viral load on 2 day, achieving what takes Tamiflu 3-4 days. CDC even lists Baloxavir on their website as one of the top 4 drugs that it tracks whether it works against new flu strains (it works)Image
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2) "Baloxavir was associated with significantly more rapid declines in infectious viral load than placebo or oseltamivir (Figure 3A and 3B)."
nejm.org/doi/full/10.10…
3) Adverse events for baloxavir were no different than placebo. in fact theres even hints that it could be lower than Tamiflu.

"Adverse events that were considered to be related to the trial regimen were more common in oseltamivir recipients (8.4%) than in baloxavir recipients (4.4%, P=0.009)"Image
Read 13 tweets
Feb 14
⚠️WORST FLU SEASON ever since 2002-2003 when we began to track flu (red, first graph). Worst hit this year are children ages 0-4 and 5-17. ▶️We also have significantly LOWER flu vaccine uptake this year, one of the lowest flu vaccine coverages (red 3rd graph). Indisputable facts. Image
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2) I don't need to tell you that certain US states have vastly lower vaccination rates than others. See map (lighter green, less flu vaccination coverage), and which have higher (darker green)...

If you want to see details and demographics on which state has the LOWEST flu vaccine coverage rates... the data is here.
cdc.gov/fluvaxview/das…Image
3) It’s not just the flu that is going around… Gaines County, TX, where the epicenter of the measles outbreak is, has one of the lowest measles vaccination rates too.
Read 7 tweets
Feb 11
INFLUENZA REACHES EPIDEMIC THRESHOLD in New York—Influenza A (Unknown variety) positivity soars (yellow), while hospitalizations stand higher than past 3 years. The rise of unknown subtyping Flu A has led NY to issue new alert to subtype all Flu A immediately for bird flu. Image
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2) This was the reason for the urgency in NY issuing an alert to subtype all hospitalized cases for bird flu if Flu A. See thread below 👇
3) the testing memo seems very aggressive for bird flu.
Read 7 tweets
Feb 10
BREAKING—22 States sue to block Trump WH cuts to NIH research grants. Image
2) Attorneys general representing 22 states sued the Trump administration on Monday, asking a federal judge to temporarily block a major policy change by the National Institutes of Health that would substantially limit payments for research overhead

statnews.com/2025/02/10/nih…
3) In the lawsuit, filed in U.S. District Court for the District of MA, the AGs argued that NIH’s abrupt decision to set a 15% cap on payments for indirect costs would cause major harm to institution budgets, jeopardizing basic operations and medical research.
Read 5 tweets
Feb 8
💣TORPEDOING MEDICAL RESEARCH—NIH indirect grant funding just got slashed by Trump to 15%. What does this mean for you? Colleges and universities won’t be able to support students, tuition will increase, especially graduate students & researchers who find cures/preventions for cancer, diabetes, heart disease, Alzheimer’s and more. This will not only raise tuition and hurt pipeline of future scientists/doctors, but COMPLETELY DECIMATE MEDICAL & PUBLIC HEALTH RESEARCH. It will also give more power to big pharma to manipulate research agendas and buy out ideas that should remain in the public domain. Ie THE RICH BIOTECH TYCOONS (eg Vivek Ramaswamy) WILL GET RICHER. The lay public will someday only see future drug/tech prices soar as biotech and big pharma control more science and make more money.

Also, Trump’s NIH posted this graphic - but it ignores that most public universities also heavily rely on indirect to subsidize tuition, and train next generation of scientists and medical doctors doing research. (Public colleges can’t compete with wealthier schools who do have endowments, and hence will fall further behind). Public colleges that do medical research will literally fall apart without this mechanism.Image
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2) People don’t seem to get 2 things:

📌Indirect funds college administration and facilities and support services. Academic advising, building operations, new labs and classrooms for students— where does that money come from? If not indirect grants, then it’ll have to come more from ⬆️student tuition.
3) Most universities don’t have billion+ endowments. Most have almost none — so when you slash NIH indirect grant funding to just 15%… it hurts small schools and public colleges the most—smaller places might even go under. Rich school survive, public schools do not.
Read 4 tweets

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