Thread by @profshanecrotty

Outstanding new preprint studying immune memory after COVID-19 for 8 months, assessing memory T & B cells in addition to antibodies. High quality work from the Ahmed, McElrath, @SutharLab , and Wrammert labs! 🧵

medrxiv.org/content/10.110…

Beautiful application of a new power law approach to calculate the trajectory of decay of T & B cell memory as well as antibodies to SARS-CoV-2, which could be well applied here due to the longitudinal study design.

This is consistent with the idea that each immune memory types consists of multiple subcomponents, with some subpopulations having more duration that others.

Lots of findings consistent with what we reported (lots!), and reported by other groups, for memory B cells, memory CD4 T cells, memory CD8 T cells, and antibodies.
science.sciencemag.org/content/371/65…

But now in this study with more rigorous longitudinal data and temporal modeling. And a whole lot of additional bits! 😀 An outstanding contribution by Julie McElrath and colleagues to the literature! 👏

Also, this is yet another paper observing stable antibody titers to common cold coronaviruses (hCovs) over time, indicating people do have long term memory to those coronaviruses. Something I (and others) have been suggesting for over a year to be likely.

(Common cold memory longevity discussed here doi.org/10.1016/j.cell… )