The Crotty Lab journal club this week was from the Brink lab. Sundling et al.: “Positive selection of IgG+ over IgM+ B cells in the germinal center reaction”. 🧵 @ImmunityCP
doi.org/10.1016/j.immu…
doi.org/10.1016/j.immu…
Using various mouse models, the authors sought to understand the process by which IgG antibodies come to dominate mature antibody responses.
High-affinity IgG+ germinal center B cells are positively selected over high-affinity IgM+ germinal center (GC) B cells via a process based on antigen receptor constant regions 
Strikingly, by using additional engineered mice, they found that unswitched IgD+ GC B cells, but not IgM+ B cells, could persist in the GC, suggesting a distinctive attribute of IgM BCRs compared to IgD or IgG.
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