Zinc supplementation hugely reduces infection rates in the elderly.

But, is this from correcting a poor diet, or offsetting aging, or both?
As we age, our thymus gland, which is critical to immunity, shrinks dramatically.

But in old mice, zinc supplementation can regrow the thymus, with a full recovery of thymus function.

This could be why zinc helps human immunity in the elderly. sciencedirect.com/science/articl…
A number of different experimental treatments that regrow the thymus are all thought to involve zinc.

So it would appear that zinc supplementation as you get older could help maintain immune function and resistance to infections and cancer.

sciencedirect.com/science/articl…
Zinc supplementation in "elderly" - average age 64 lol - men doubled their testosterone levels.
sciencedirect.com/science/articl…
Zinc abolishes alcohol-induced leaky gut. Therefor zinc could be useful against autoimmune diseases, chronic fatigue, IBS, etc. journals.physiology.org/doi/full/10.11…

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More from @Mangan150

14 May
Blood clotting and long, healthy life.

A loss-of-function mutation in the gene that encodes for PAI-1 is associated with lower fasting insulin, and...

7 years longer lifespan - huge.

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advances.sciencemag.org/content/3/11/e…
PAI-1 is plasminogen activator inhibitor, and increased levels mean less fibrinolysis, and a tendency for blood to remain clotted.

Increased PAI-1 is associated with obesity, particularly visceral fat.

nature.com/articles/nm079…
Patients with peripheral arterial disease have higher PAI-1, and exercise training significantly reduces it.

sciencedirect.com/science/articl…
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Do you want to lose 15, 20, or even 30 pounds in the next 90 days?

And keep it off forever?

I’ve got something for you

You see, there’s a lot of advice out there about getting lean

A lot of it "works", per se

The problem is...
Almost every “hack” or strategy you hear about is either

*complicated and time consuming, and so not designed for your real life

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I’ve refined my system so it’s at the intersection of

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1 May
Iron depletion by phlebotomy (bloodletting) improves insulin sensitivity in patients with fatty liver.
gastrojournal.org/article/S0016-…
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The largest source of iron is grains, because flour is enriched with iron.

fns-prod.azureedge.net/sites/default/…
Metformin may improve insulin sensitivity in part through reduction in body iron stores. eje.bioscientifica.com/view/journals/…
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30 Apr
A few years ago my mother had a stroke and was in ICU. After discharge she went to a convalescent hospital for a few weeks.

The food there was appalling. Sugar and cheap carbs everywhere. Imagine oatmeal with maple syrup and a glass of OJ for breakfast.
So I requested a meeting with the lead dietitian. I told her that I wanted my mother to get bacon and eggs for breakfast, and none of that sugary stuff. Meat or eggs at every meal.

She looked at me like I was from Mars, but ultimately she complied.
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30 Apr
Use of metformin and acarbose is associated with reduced risk of death from Covid-19.

No one using both meds before admission died.

Metformin lowers blood glucose, and acarbose blocks dietary glucose absorption.

Could you get same risk reduction by not eating carbs?
No association with insulin or other meds.

assets.researchsquare.com/files/rs-28730…
Metformin Associated with Decreased Covid Mortality Among Nursing Home Residents

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Elite athletes have disturbed glucose control.

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
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