[1/n] 10 days ago we first shared blueprint of O2 conservation devices in context of #OxygenShortage; today we are releasing "Anmo2l" (means priceless in Hindi) - a ready to scale open design capable of saving 50-70% oxygen during O2 therapy. See anmo2l.org details.
[2/n] The surge of COVID-19 cases in India and around the world has resulted in an acute oxygen shortage. We describe a simple, open source, and rapidly manufacturable conservation device for use with dual port nasal cannulas saving oxygen supply by almost two or three times.
[3/n] We are looking for partners/manufacturers across world to help bring this to patients. If you have experience in local regulatory processes, we want to support you to bring this rapidly to communities suffering with O2 shortage including India/Nepal, Latin America, Africa.
[4/n] Current estimates put the O2 demand in India at 15.8 million cubic meters or 2.2 million O2 cylinders per day. O2 delivered during patient exhalation is mostly vented to air & wasted, providing opportunity for O2 conservation by shutting flow when the patient is exhaling.
[5/n] This has been intense 10 days.. but we are ready to start large scale clinical validation. We are looking for partner clinical groups in India/Nepal/Africa/Latin-America to grow the current clinical team - we intend to collect extensive validation data prior to approval.
[6/n] The current design keeps the current supply chain in mind; with alternative components accessible for all key components. In larger scale, we believe we can bring cost per unit to be lower than ~$50. The device also has "fail-open" in case of loss of power.
[7/n] It has been an incredible last 10 days - to go from idea to product - led by @hongquan_li @deepak_me90 @anesta_k @lietk12 in the lab - & incredible support from @mlipnick David Gaba, Ruth Fanning & clinicians & engineering team @IndiaCOVIDSOS & more anmo2l.org/team
[8/n] We still need a lot of support to get this to the last mile - if you are interested in helping us scale this to all corners of the world; please do reach out. We can use all the help.. anmo2l.org/support
[9/n] For folks looking for technical details - here is a PDF file we have posted to MedRxiv: anmo2l.org/documents/medr… Once it is available online, will share the MedRxiv link.

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More from @PrakashLab

27 Apr
[1/n] "Oxygen" - If you know anyone in India - it's one word you hear over & over. It's a critical life saving supply. In context of COVID surge in India, we are sharing open source design for "pulse dose" O2 conservation device - potential to save 50% O2. Not medical device yet.
[2/n] The idea "pulse dose system" is simple. When you exhale, you don't take in O2 while the tank still delivers. For mild COVID19 patients on nasal cannula - this O2 is wasted. A simple pressure based detection & an electronic valve can release O2 only during inhalation.
[3/n] The implementation above is simple - and not a medical device. A lot of work still needs to be done and tested clinically. We are releasing the design/implementation in open source - to engage manufacturing partners in an emergency. docs.google.com/document/d/1gN…
Read 9 tweets
5 Sep 20
(1/n)Excited to announce new course I have been planning for 5 years BioE271: Frugal Science frugalscience.org structured as global participatory class open to all. 50% Stanford students 50% global participant. Learn how to solve serious challenges with little bit of play
(2/n)Together we will explore principles of frugal science to design scalable solutions with cost/performance rubric. With examples we will look at imp of fundamental science of everyday building blocks. We will juggle rigors of applied math/physics with creativity of a toy maker
(3/n) Global Participatory Community Health Track:
Can we diagnose deadly infectious diseases under a tree? Environmental Planetary-Health Activists Track: Can we build tools to make measurements at planetary scale.
Read 10 tweets
20 Jul 20
(1/n) Excited to share #Pufferfish an open-source full-feature mechanical ventilator reference design capable of volume & pressure control with assist modes, both invasive/non-invasive ventilation & features necessary to support COVID19 patients pez-globo.org
(2/n) Pufferfish is a result of a large scale intl collaborative effort - Pez-Globo - between my lab @Stanford, @brownengin @FluidDanamics & @UofU_Anesthesia @kkuck - clinicians, engineers, scientists, industrial/manufacturing partners @BharatForgeLtd @Waymo @BlackrockMicro
(3/n) Heart of whole operation are students, postdocs, clinicians, innovators & volunteers - working with tenacity, precision & passion I have never witnessed before - too many to name individually (list pez-globo.org/core-team) - spreading across US, India, Nepal and Kenya
Read 18 tweets
3 Jul 20
(1/n) Excited to share Handyfuge-LAMP; a low-cost & electricity-free centrifugation for isothermal SARS-CoV-2 detection in saliva. With COVID19 cases increasing globally, diagnostics needs to be accessible to everyone - including resource limited regions medrxiv.org/content/10.110…
(2/n)This simple electricity-free LAMP protocol builds on fantastic work by Cepko lab at Harvard [medrxiv.org/content/10.110…], but with ahand powered centrifuge to make this assay completely electricity free for resource constrained settings. All you need is everything in this pic.
(3/n) If you would like to try it, here is the visual summary of every step of the way; with centrifugation steps linked below.
Read 10 tweets
7 May 20
(1/n) Thrilled to share latest pre-print from lab - open imaging tool we have been working for the last 3 years "PlanktonScope V1 & 2" - modular (100x cost reduction) platform to enable citizens/sailors to study the world's largest habitat - our oceans! biorxiv.org/content/10.110…
(2/n) Before describing the science/vision and the back story of 'Planktonscope" - it's important to highlight the incredible trio in lab that made this dream come true - led by Thibaut Polina @chevreuil3000, Adam Larson @planktonico & @hongquan_li - merging of art/design/science
(3/n) What is the problem we are trying to solve? The ocean is a big place (360 million sq km) - and presence/absence & type of microscopic life in ocean holds secrets to well being of our planet. Not enough research vessels/scientists/$ to map this microscopic life in its glory
Read 15 tweets
29 Apr 20
(1/n) What does cotton-candy machine, van de graaff generator & COVID19 have in common? Here we present a possible solution for distributed, small scale manufacturing of N95 material for communities that can not source pre-approved masks. Pre print: arxiv.org/abs/2004.13494
(2/n) Disclaimer: If you have access to an authentic N95 mask, that is the best possible solution. But majority of parts around the world, N95 supplies have never existed. How can we boot-strap and support small scale manufacturing capacity for this critical supply locally?
(3/n) Our journey began a month ago when we had first shared results on use of cotton-candy machine to spin polypropylene fibers:
Only possible because of incredible students Anton Molina, @Pranavvyas94 @nikitakhlystov and co-authors.
Read 12 tweets

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