Here it is: The #cryoEM structure of the ChAdOx1 @AstraZeneca #vaccine vector, and it's cell binding fiber knob protein.
We show how this vector can bind to human cells and suggest a how it may bind to PF4. We discuss how this may play a role in #VITT
biorxiv.org/content/10.110…
We show how this vector can bind to human cells and suggest a how it may bind to PF4. We discuss how this may play a role in #VITT
biorxiv.org/content/10.110…
At risk of an Oscar worthy spiel: @rjboyd000, @17Dsarkar, @Aly25_09 deserve credit for fantastic work, and more for putting up with me every day.
Great to work transatlantic with the @virustinkerer @abhisekhsingha1 @BoradLab labs. 5 institutions contributed to this.
Great to work transatlantic with the @virustinkerer @abhisekhsingha1 @BoradLab labs. 5 institutions contributed to this.
I should also clarify: The capsid structure is a CryoEM solve. The fiber knob structure is crystallography, done at super high speed, by @Aly25_09 .
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