Discover and read the best of Twitter Threads about #VITT

Most recents (24)

POLL:
Now we know that people died as a result of #VITT that could have been prevented had the treatment protocols been rolled out earlier, please read this short transcript of an interview with the @TGAgovau's John Skerritt and vote in the next tweet

health.gov.au/news/therapeut…
Did John Skerritt of the TGA and @JimWilsonMedia of @2GB873 conspire to purposefully underplay the risk of #VITT with #AstraZeneca - which could have been treated if doctors were aware of the problem - and were therefore responsible for unnecessary deaths?
According to the TGA the handful of deaths documented from vaccines have all been associated with #Astrazeneca

But TTS (VITT) deaths stopped once treating doctors were aware of the problem.

By June 2021, TTS fatalities were being reported
tga.gov.au/periodic/covid…
Read 5 tweets
9 months ago today I collapsed at home 14 days after my 1st AstraZeneca. I’m here when I shouldn’t be. I lost my left leg from above the knee and I have numerous other things going on. All from the vaccine. I was a really fit and healthy person with no underlying health issues.
All this has been confirmed in writing by the Heomotology team at Hairmyres University hospital and has been medically classified as Vitt( vaccine induced thrombotic thrombocytopenia). But the uk government don’t accept what happened was vaccine related. #VITT Till I die
My last for today. I did this last week scooterlab.uk/scooterist-los… it may answer some questions.
Read 3 tweets
Vector-based SARS-CoV2 #vaccines have been associated with vaccine-induced thrombotic thrombocytopenia #VITT/#TTS. It is known that similar to HIT, anti-PF4 antibodies are formed which activate platelets therefore eventually leading to serious thrombosis: nature.com/articles/s4158…
This serious and sometimes fatal condition has been described for both vector-based SARS-CoV2 vaccines ChAdOx1 nCoV-19 (AstraZeneca) and in less frequency for Ad26.COV2.S (Johnson&Johnson). However, it is still unclear why there are large differences in the incidence of #VITT.
To tackle this question, we dropped everything else and compared both vaccines in our local, highly interdisciplinary multi-expertise group from @uni_greifswald, @UMGreifswald and @Loeffler_News: #GreifswalderForscher
Read 11 tweets
How the UK government, media and scientists were complicit in misleading the British public after Europe raised concerns about the #Oxford #AstraZeneca #Vaccine

A semi-satirical 🧵in the form of a PR crisis management guide, created using real quotes from March and April 2021 Image
The situation:

Norway has made nightmarishly specific statements about blood clots they found in AstraZeneca recipients

The clots are really unusual and serious and will put people off the 🇬🇧 vaccine which would be a disaster for the UK roll out - and a knock to national pride Image
Step 1: Change the conversation to blood clots in general Watch from 1:48 as the UK’s absolutely, definitely, certainly not state-controlled broadcaster transforms the unusual clots into ordinary blood clots!

Cheers Ros and the BBC "News" team!
Image
Read 43 tweets
Adverse reactions June '21
'I personally know 3 people in their 30s, who have suffered mild heart attacks, all within 8 days of receiving Covid vaccines...' Ian Clayton @AI_Clayton
'Similar situ with me Ian. My own relative sadly passed away of a stroke post AZ 2nd dose. And I know several others who have suffered serious life-changing adverse reactions. ..'
CaitlinGrey Cherry blossom
@GreyCaitlin
Read 34 tweets
The vaccine rollout is spreading - and so is the delta variant. Lots of folks are concerned about the risk of myocarditis in young people who receive mRNA. My advice: make sure your sources include true experts - in this case, doctors who look after heart disease in kids. 1/n
My experience with #VITT left me shaken, as misinformation about blood #clots was amplified (often by other MDs). Science & medicine are a big tent. BUT within those tents are people with specialized training and experience - and their words should carry weight! 2/n
Definitely look at studies, watch the CDC's ACIP live streams, consider the words of doctors, nurses, PH, epidemiologists, scientists of all stripes. But pay close attention to the words of FPs, pediatricians & pediatric cardiologists. I'm happy to speak *around* this issue. 3/n
Read 7 tweets
du @BeatGlogger @higgsmag wäre das ein vorschlag für 1 gemeinsames #feedlog

wir gehen die punkte durch:
- und zeigst, was #ClemensArvay nicht korrekt auf die reihe bekommt? (so?) #CoronaViurs

#thread: "mRNA-Impfstoffe: Erste Hinweise auf Langzeitfolgen"
@BeatGlogger @higgsmag 1. aussage: mRNA-impfstoffe, könnten ihr immunsystem "nachhaltig" reprogrammieren
@BeatGlogger @higgsmag 00:00:31 dein werbesponsor @JNJ_ch wird erwähnt.
Read 24 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
What is the incidence of VITT after 2nd AZ vaccination? The MHRA are saying 1.3 per 1 million. I say it may be a lot less and could be zero. #VITT #COVIT19 1/7
We do not know much about the 2nd dose VITT cases that the MHRA claims to have had reported to them. They are all >50 but we do not know anything else. Why do they not publish type of thrombosis, age, sex, co-morbidities, anti-PF4? 2/7
It is accepted that the MHRA have had 18 reports of thrombosis with thrombocytopenia after 2nd dose AZ vaccine. But are they VITT? Do they definitely not have cancer or sepsis? Do they fulfil the attached typical VITT definition? 3/7 Image
Read 7 tweets
Secondo questo professore di epidemiologia della Mayo Clinic, che ha raccolto le informazioni su az e #VITT (trombosi con trombocitopenia) l'incidenza dopo la prima dose sarebbe più alta di quanto si pensava: 1/55mila.
Dopo la 2° sarebbe 1/mezzo milione.
Nel Regno Unito sono sinora stati 242 i casi, su circa 22 milioni di prime dosi.

In Italia le informazioni che ha raccolto segnalano 11 casi su 1.6 milioni di prime dosi.

La qualità dei nostri dati è "incerta".
Con questa incidenza (1 caso ogni 55mila, con letalità dei casi 20-30% cioè a spanne un decesso ogni 200mila prime dosi) il professore ritiene che "dove possibile, negli under30, sia da preferire un vaccino mRNA).
Read 13 tweets
UPDATE: Risk Serious Blood Clots following Astra Zeneca/COVISHIELD vaccine. #VITT

~1 in 55,000 with 1st dose.
This is higher than we thought initially.

Risk with 2nd dose is 10 times lower.

I'd favor mRNA vaccines, if possible, for age <30 years. covid19-sciencetable.ca/sciencebrief/r…
As the report indicates, the risk from countries with moderate to high data data quality range from 1 in 26,500 to 1 in 127,300 of first doses.
My previous estimates are in this thread from April. There are relatively smaller number of J&J doses. So erring on side of caution for now I would consider risks to be similar.
Read 6 tweets
DVT as a feature of #VITT: unusual in the UK / Europe yet common in Australia - could cases have been missed?

NB this is a loose theory, not an assertion

Here are some observations
On 20 May ATAGI reported a breakdown of types of clot seen in 🇦🇺 VITT cases

Of 21 confirmed + 3 probable cases, DVT was present in 12 (50%)

Even excl. probables + assuming all 3 included DVT, that would mean DVT present in minimum 9 / 21 = 43% VITT cases
tga.gov.au/periodic/covid…
In Europe only 3 / 45 (7%) cases across 4 published papers (Schultz, Greinacher, Scully, Tiede) + 1 unpublished study (Scavone) include DVT according to a paper by M Cattaneo

This is strikingly different from the Australian data - what could explain it?

ncbi.nlm.nih.gov/pmc/articles/P…
Read 12 tweets
Here it is: The #cryoEM structure of the ChAdOx1 @AstraZeneca #vaccine vector, and it's cell binding fiber knob protein.

We show how this vector can bind to human cells and suggest a how it may bind to PF4. We discuss how this may play a role in #VITT

biorxiv.org/content/10.110…
At risk of an Oscar worthy spiel: @rjboyd000, @17Dsarkar, @Aly25_09 deserve credit for fantastic work, and more for putting up with me every day.
Great to work transatlantic with the @virustinkerer @abhisekhsingha1 @BoradLab labs. 5 institutions contributed to this.
I should also clarify: The capsid structure is a CryoEM solve. The fiber knob structure is crystallography, done at super high speed, by @Aly25_09 .
Read 3 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
LONG week on call @HamHealthSci. Lots of calls about #VITT post AZ vaccine. I'm transparent w my patients - I believe empowerment leads to earlier detection, better outcomes, less stress. So I'm grateful to @heysciencesam for creating tools to help me be transparent with YOU! 🧵
If you've had AZ 4-28 days ago, be on the lookout for the following symptoms. If you have them, seek medical attention! (Sam, thx for making the doctor in this graphic look JUST LIKE ME 😜 #GenXZeneca #WomenInMedicine)
How do migraine sufferers know if this is a VITT headache? VITT headache often worse, more persistent, or has diff features than your usual headache. It might go with visual changes. When in doubt: seek care. We're educating clinicians about VITT here: covid19-sciencetable.ca/sciencebrief/v…
Read 10 tweets
Updated guide from the @COVIDSciOntario to Vaccine-Induced Immune Thrombotic Thrombocytopenia #VITT Following Adenovirus Vector COVID-19 Vaccination!
Thank you for this lay summary! @MPaiMD
Key takeaways 🧵⤵️ 1/ #science #MedTwitter #scicomm #COVID19 #COVID19Vaccine
▶️ Blood clots can occur 4 to 28 days post 💉 & associated w/ ⬇️ platelets
▶️ These clots...are more aggressive and are more likely to cause death or severe disability...
▶️ Rate of VITT in Canada has been estimated to be ~1/ 100k doses 2/
Re: contraindication: It may be possible... people with a history of HIT or CSVT w/ ⬇️ platelets are at ⬆️ risk of VITT; they should receive an mRNA vaccine (Pfizer or Moderna) rather than an adenoviral vector vaccine. 3/
Read 8 tweets
⭐️ @COVIDSciOntario’s UPDATED guide to Vaccine-Induced Immune Thrombotic Thrombocytopenia #VITT Following Adenovirus Vector COVID-19 Vaccination! covid19-sciencetable.ca/sciencebrief/v… Image
If you’re NOT a healthcare professional, we have a lay summary for you here: covid19-sciencetable.ca/sciencebrief/v…
And targeted guides for outpatient and ED/inpatient settings are coming soon! (We’ve been working so hard on this our keyboards have caught 🔥. Need a quick breather.)
Read 6 tweets
"Prioritise the elderly & high risks"

Easy to be said,
NOT easy to be done.

Many elderly people are still vaccine-hesitant:their main source of info is "fear-mongering" Whatsapp chain messages.

This is a 🧵on #COVID vaccine's risk & why we should not wait for an IDEAL vaccine.
2/ Many of the high risk patients who we counselled for vaccine still are hesitant & adopted approach of "Tunggu Dulu la"
Despite our best efforts explaining the risks

Remember when Pfizer first came out? Many people went bonkers over the anaphylaxis issue despite reassurances.
3/ When Pfizer came out, people say "oh I wanna wait for AZ/Sinovac/J&J"

Now AZ are in, people are super scared over the risk of VITT (blood clots):they are saying "Let's wait for Pfizer" 🤷🏻‍♀️

J&J also has reports of VITT now.

Sinovac has minimal data on adverse effects for now.
Read 12 tweets
Det Danske #COVID19 vaccinationsprogram udfrodres af Vaccine-induceret Immun
Trombose og Trombocytopeni (VITT). Først AZ- og nu J&J vaccine sparket til hjørne. Grundig gennemgang fra @SSTSundhed @SSTbrostrom for interesserede: sst.dk/da/Udgivelser/…
Men hvad er VITT ? 👇👇👇 1/9
#VITT er sjældent forekommende bivirkning til #COVID19 vaccine (AZ/J&J) m forekomst 1/40.000 vacciner (US data for J&J ventes at lande på ca samme forekomst når data videre opgøres!). Vores udfordring : Vi kan ikke finde patienterne på forhånd, enhver kan være i risiko 2/9
Alle aldersgrupper rammes af #VITT, estimeret lidt hyppigere hos unge voksne (< 50 år), begge køn rammes ligeligt (50:50%) og der er ikke kendte risikofaktorer. Forudgående sygdom m risiko for blodprop, livsstilssygdomme eller blødninger øger ikke risiko. 3/9
Read 9 tweets
Everyone keeps telling you that the side effects from AstraZeneca and Jansen vaccines are rare and you should get the vaccine. I totally 100% agree with this, but trust is only part of the equation. So here’s what I know about #VITT or vaccine induced thrombotic thrombocytopenia.
Let’s start with the name, because it tells us a bit about the problem. Thrombocytopenia means a low platelet count, which can happen for many reasons, and thrombotic refers to the generation of blood clots. When you understand that platelets are what start most clots ....
You really are a leaky meat bag. No offence. Platelets are constantly plugging tiny holes in blood vessels and maintaining vascular health. They are kind of like clotting grenades. Super effective at what they do, but you don’t want them going off in the wrong place.
Read 14 tweets
Some current Hematologic diagnostic & management dilemmas of Adenovirus #JNJ & #AstraZeneca #VITT:
1⃣VITT seems to behave like autoimmune (Type 2) HIT rather than non-immune (Type 1) HIT (more common).
(Greinacher et al, @JTHjournal, 2017)
1/
#MedTwitter #HemeTwitter #COVID19 Figure 3. Generation of the heparin‐induced thrombocytopen
2⃣High enough doses of heparin or LWMH can outcompete these PF4-polyanion complexes for binding sites & reduce platelet aggregation (similar to HIT).
➡️BUT, we can't yet tell where/if there's a consistent dose breakeven point at which aggregation⬇️
(Schultz et al, @NEJM, 2021)
2/ Note: High-dose/concentration Heparin in these assays is 100
➡️While many cases reported using LMWH (mostly low-dose Dalteparin), lab results were inconsistent on whether this sufficiently reduced/prevented platelet aggregation.

(Greinacher et al, @NEJM, 2021)
3/ Note: There was a discrepancy in LWMH reaction between the 4
Read 18 tweets
#JNJ Vaccine Cerebral Venous Sinus Thrombosis Surveillance🧵after @CDCgov #ACIP (for now ...):
1⃣Watch for symptoms like headache, aphasia, paresis, papilledema, seizure, mental status changes
2⃣High-risk groups *seem* to be young women (~20-50), 6-20 days after #JNJ vaccine

1/
3⃣True #CVST event rate is TBD (as is the true background rate)
4⃣PF4 IgG ELISA in all patients for screening (#publichealth reporting) & management (avoiding heparin if positive)
5⃣Consider IV steroids & IVIg for thrombocytopenia
#HemeTwitter
2/
6⃣Report any suspicious events to #VAERS vaers.hhs.gov/reportevent.ht…
7⃣Remember that these are RARE events and the proposed cause of #VITT remains theoretical. This pause is proof that the safety/surveillance system works!

3/
Read 6 tweets
The @CDCgov Advisory Committee on Immunization Practices (ACIP) emergency meeting on the #JNJ vaccine is ongoing. Currently, they're reviewing known data on 8 cases of thrombotic thrombocytopenia. Follow this thread for updates. 1/ #COVID19 #MedTwitter ustream.tv/channel/VWBXKB…
This was the initial @US_FDA announcement yesterday describing the #COVID19Vaccine #JNJ hold. In summary, 6 post-market cases of cerebral venous thrombosis reported as of yesterday (in ~6.8 million doses delivered) prior to the hold.
The awesome @acweyand excellently summarized the data known as of yesteday from the similar #AstraZenaca adenovirus vector vaccines and background on #CVST! #hemetwitter 3/
Read 20 tweets
Astra Zeneca vaccine & blood clots. Summary.

Rare form of blood clots plus low platelets. ~60% involve veins of brain. Almost all after 1st dose.

Risk (UK MHRA): 1 in 250,000 people
Risk (EU EMA): 1 in 100,000 people

Risk of dying: 20-25% of people with these clots have died
Approximately half of the deaths in the UK (11 of 19) were under age 50.

The benefits of the Astra Zeneca vaccine according to regulators appear to outweigh risks in all except those less than age 30. bmj.com/content/373/bm…
While blood clots occur at a certain rate in population what is unusual about these clots is the association with low platelets. Platelets help make blood clots & when platelets are low we are at risk of bleeding not clotting.

Low platelets in context of blood clots is unusual.
Read 13 tweets

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