Discover and read the best of Twitter Threads about #VITT
Most recents (24)
Now we need a charity to raise funds for pro bono autopsies of #DeathByVaxx.
As the pathology of Dr. Arne Burkhardt and @drcole12 found, 💉 spike protein in EVERY ORGAN causing massive lymphocyte infiltration and cell necrosis.
#Evidence #Nuremberg2
As the pathology of Dr. Arne Burkhardt and @drcole12 found, 💉 spike protein in EVERY ORGAN causing massive lymphocyte infiltration and cell necrosis.
#Evidence #Nuremberg2
We've got the path slides! 😎
1/ Dem Foto nach zu urteilen referierte #STIKO-Chef Thomas Mertens auf der mit über 100000 Euro Pharma-gesponserten Jahrestagung der GESELLSCHAFT FÜR VIROLOGIE über die wechselnden Empfehlungen der Kommission zur #Impfung mit #AstraZeneca:
„The updates made over time …
„The updates made over time …
2/ … are ‚an expression of the careful analysis of constantly changing and newly added scientific findings, which are published in rapid succession in view of the dynamics of research on #Covid19‘.
The problem in this case is the lack of understanding for a COMPLETELY NORMAL …
The problem in this case is the lack of understanding for a COMPLETELY NORMAL …
3/ … AND ESSENTIAL SCIENTIFICALLY BASED PROCEDURE.“
Sollten diese „careful analysis of scientific findings“ und die „scientifically based procedure“ nicht viel eher VOR dem Massen-Rollout eines neuen Impfstoffes, und nicht erst im Post-Marketing erfolgen??? …
Sollten diese „careful analysis of scientific findings“ und die „scientifically based procedure“ nicht viel eher VOR dem Massen-Rollout eines neuen Impfstoffes, und nicht erst im Post-Marketing erfolgen??? …
1/ Es bleibt dabei:
Auch meine Einsicht in die Studie aus @NatureComms bestätigt, was der TELEGRAPH schreibt:
Das Risiko für „cardiac registered death“ für junge Frauen (12-29 J.) innerhalb von drei Monaten nach einer Dosis #AstraZeneca betrug ca. 1:16000 (sic!). …
Auch meine Einsicht in die Studie aus @NatureComms bestätigt, was der TELEGRAPH schreibt:
Das Risiko für „cardiac registered death“ für junge Frauen (12-29 J.) innerhalb von drei Monaten nach einer Dosis #AstraZeneca betrug ca. 1:16000 (sic!). …
@bhwords Dr. Beverley Hunt presenting on #COVID19 and #thrombosis. She wants to chronologically review the battles we have fought! #ASH22 1/n
Anti-platelet glycoprotein autoantibodies after ChAdOx1 vaccination are as common in VITT as in non-VITT thrombocytopenic patients. tinyurl.com/2y2na7wu #VITT 1/3
Of greater importance is the observation that in mice, intravenous but not intramuscular administration of ChAdOx1 (AZ vaccine) leads to platelet-adenovirus aggregates and platelet activation. tinyurl.com/2y2na7wu #VITT 2/3
Although this is an animal study, it is nevertheless important because it shows the differential response to intramuscular and intravenous exposure to ChAdOx1 vaccine. #VITT 3/3
9 months ago today I collapsed at home 14 days after my 1st AstraZeneca. I’m here when I shouldn’t be. I lost my left leg from above the knee and I have numerous other things going on. All from the vaccine. I was a really fit and healthy person with no underlying health issues.
All this has been confirmed in writing by the Heomotology team at Hairmyres University hospital and has been medically classified as Vitt( vaccine induced thrombotic thrombocytopenia). But the uk government don’t accept what happened was vaccine related. #VITT Till I die
My last for today. I did this last week scooterlab.uk/scooterist-los… it may answer some questions.
Vector-based SARS-CoV2 #vaccines have been associated with vaccine-induced thrombotic thrombocytopenia #VITT/#TTS. It is known that similar to HIT, anti-PF4 antibodies are formed which activate platelets therefore eventually leading to serious thrombosis: nature.com/articles/s4158…
This serious and sometimes fatal condition has been described for both vector-based SARS-CoV2 vaccines ChAdOx1 nCoV-19 (AstraZeneca) and in less frequency for Ad26.COV2.S (Johnson&Johnson). However, it is still unclear why there are large differences in the incidence of #VITT.
To tackle this question, we dropped everything else and compared both vaccines in our local, highly interdisciplinary multi-expertise group from @uni_greifswald, @UMGreifswald and @Loeffler_News: #GreifswalderForscher
How the UK government, media and scientists were complicit in misleading the British public after Europe raised concerns about the #Oxford #AstraZeneca #Vaccine
A semi-satirical 🧵in the form of a PR crisis management guide, created using real quotes from March and April 2021
A semi-satirical 🧵in the form of a PR crisis management guide, created using real quotes from March and April 2021
The situation:
Norway has made nightmarishly specific statements about blood clots they found in AstraZeneca recipients
The clots are really unusual and serious and will put people off the 🇬🇧 vaccine which would be a disaster for the UK roll out - and a knock to national pride
Norway has made nightmarishly specific statements about blood clots they found in AstraZeneca recipients
The clots are really unusual and serious and will put people off the 🇬🇧 vaccine which would be a disaster for the UK roll out - and a knock to national pride
Step 1: Change the conversation to blood clots in general Watch from 1:48 as the UK’s absolutely, definitely, certainly not state-controlled broadcaster transforms the unusual clots into ordinary blood clots!
Cheers Ros and the BBC "News" team!
Cheers Ros and the BBC "News" team!
Adverse reactions June '21
'I personally know 3 people in their 30s, who have suffered mild heart attacks, all within 8 days of receiving Covid vaccines...' Ian Clayton @AI_Clayton
'Similar situ with me Ian. My own relative sadly passed away of a stroke post AZ 2nd dose. And I know several others who have suffered serious life-changing adverse reactions. ..'
CaitlinGrey Cherry blossom
@GreyCaitlin
CaitlinGrey Cherry blossom
@GreyCaitlin
The vaccine rollout is spreading - and so is the delta variant. Lots of folks are concerned about the risk of myocarditis in young people who receive mRNA. My advice: make sure your sources include true experts - in this case, doctors who look after heart disease in kids. 1/n
My experience with #VITT left me shaken, as misinformation about blood #clots was amplified (often by other MDs). Science & medicine are a big tent. BUT within those tents are people with specialized training and experience - and their words should carry weight! 2/n
Definitely look at studies, watch the CDC's ACIP live streams, consider the words of doctors, nurses, PH, epidemiologists, scientists of all stripes. But pay close attention to the words of FPs, pediatricians & pediatric cardiologists. I'm happy to speak *around* this issue. 3/n
du @BeatGlogger @higgsmag wäre das ein vorschlag für 1 gemeinsames #feedlog
wir gehen die punkte durch:
- und zeigst, was #ClemensArvay nicht korrekt auf die reihe bekommt? (so?) #CoronaViurs
#thread: "mRNA-Impfstoffe: Erste Hinweise auf Langzeitfolgen"
wir gehen die punkte durch:
- und zeigst, was #ClemensArvay nicht korrekt auf die reihe bekommt? (so?) #CoronaViurs
#thread: "mRNA-Impfstoffe: Erste Hinweise auf Langzeitfolgen"
@BeatGlogger @higgsmag 1. aussage: mRNA-impfstoffe, könnten ihr immunsystem "nachhaltig" reprogrammieren
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
What is the incidence of VITT after 2nd AZ vaccination? The MHRA are saying 1.3 per 1 million. I say it may be a lot less and could be zero. #VITT #COVIT19 1/7
We do not know much about the 2nd dose VITT cases that the MHRA claims to have had reported to them. They are all >50 but we do not know anything else. Why do they not publish type of thrombosis, age, sex, co-morbidities, anti-PF4? 2/7
It is accepted that the MHRA have had 18 reports of thrombosis with thrombocytopenia after 2nd dose AZ vaccine. But are they VITT? Do they definitely not have cancer or sepsis? Do they fulfil the attached typical VITT definition? 3/7
Secondo questo professore di epidemiologia della Mayo Clinic, che ha raccolto le informazioni su az e #VITT (trombosi con trombocitopenia) l'incidenza dopo la prima dose sarebbe più alta di quanto si pensava: 1/55mila.
Dopo la 2° sarebbe 1/mezzo milione.
Dopo la 2° sarebbe 1/mezzo milione.
Nel Regno Unito sono sinora stati 242 i casi, su circa 22 milioni di prime dosi.
In Italia le informazioni che ha raccolto segnalano 11 casi su 1.6 milioni di prime dosi.
La qualità dei nostri dati è "incerta".
In Italia le informazioni che ha raccolto segnalano 11 casi su 1.6 milioni di prime dosi.
La qualità dei nostri dati è "incerta".
Con questa incidenza (1 caso ogni 55mila, con letalità dei casi 20-30% cioè a spanne un decesso ogni 200mila prime dosi) il professore ritiene che "dove possibile, negli under30, sia da preferire un vaccino mRNA).
UPDATE: Risk Serious Blood Clots following Astra Zeneca/COVISHIELD vaccine. #VITT
~1 in 55,000 with 1st dose.
This is higher than we thought initially.
Risk with 2nd dose is 10 times lower.
I'd favor mRNA vaccines, if possible, for age <30 years. covid19-sciencetable.ca/sciencebrief/r…
~1 in 55,000 with 1st dose.
This is higher than we thought initially.
Risk with 2nd dose is 10 times lower.
I'd favor mRNA vaccines, if possible, for age <30 years. covid19-sciencetable.ca/sciencebrief/r…
As the report indicates, the risk from countries with moderate to high data data quality range from 1 in 26,500 to 1 in 127,300 of first doses.
My previous estimates are in this thread from April. There are relatively smaller number of J&J doses. So erring on side of caution for now I would consider risks to be similar.
DVT as a feature of #VITT: unusual in the UK / Europe yet common in Australia - could cases have been missed?
NB this is a loose theory, not an assertion
Here are some observations
NB this is a loose theory, not an assertion
Here are some observations
On 20 May ATAGI reported a breakdown of types of clot seen in 🇦🇺 VITT cases
Of 21 confirmed + 3 probable cases, DVT was present in 12 (50%)
Even excl. probables + assuming all 3 included DVT, that would mean DVT present in minimum 9 / 21 = 43% VITT cases
tga.gov.au/periodic/covid…
Of 21 confirmed + 3 probable cases, DVT was present in 12 (50%)
Even excl. probables + assuming all 3 included DVT, that would mean DVT present in minimum 9 / 21 = 43% VITT cases
tga.gov.au/periodic/covid…
In Europe only 3 / 45 (7%) cases across 4 published papers (Schultz, Greinacher, Scully, Tiede) + 1 unpublished study (Scavone) include DVT according to a paper by M Cattaneo
This is strikingly different from the Australian data - what could explain it?
ncbi.nlm.nih.gov/pmc/articles/P…
This is strikingly different from the Australian data - what could explain it?
ncbi.nlm.nih.gov/pmc/articles/P…
Here it is: The #cryoEM structure of the ChAdOx1 @AstraZeneca #vaccine vector, and it's cell binding fiber knob protein.
We show how this vector can bind to human cells and suggest a how it may bind to PF4. We discuss how this may play a role in #VITT
biorxiv.org/content/10.110…
We show how this vector can bind to human cells and suggest a how it may bind to PF4. We discuss how this may play a role in #VITT
biorxiv.org/content/10.110…
At risk of an Oscar worthy spiel: @rjboyd000, @17Dsarkar, @Aly25_09 deserve credit for fantastic work, and more for putting up with me every day.
Great to work transatlantic with the @virustinkerer @abhisekhsingha1 @BoradLab labs. 5 institutions contributed to this.
Great to work transatlantic with the @virustinkerer @abhisekhsingha1 @BoradLab labs. 5 institutions contributed to this.
I should also clarify: The capsid structure is a CryoEM solve. The fiber knob structure is crystallography, done at super high speed, by @Aly25_09 .
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
LONG week on call @HamHealthSci. Lots of calls about #VITT post AZ vaccine. I'm transparent w my patients - I believe empowerment leads to earlier detection, better outcomes, less stress. So I'm grateful to @heysciencesam for creating tools to help me be transparent with YOU! 🧵
If you've had AZ 4-28 days ago, be on the lookout for the following symptoms. If you have them, seek medical attention! (Sam, thx for making the doctor in this graphic look JUST LIKE ME 😜 #GenXZeneca #WomenInMedicine)
How do migraine sufferers know if this is a VITT headache? VITT headache often worse, more persistent, or has diff features than your usual headache. It might go with visual changes. When in doubt: seek care. We're educating clinicians about VITT here: covid19-sciencetable.ca/sciencebrief/v…
Updated guide from the @COVIDSciOntario to Vaccine-Induced Immune Thrombotic Thrombocytopenia #VITT Following Adenovirus Vector COVID-19 Vaccination!
Thank you for this lay summary! @MPaiMD
Key takeaways 🧵⤵️ 1/ #science #MedTwitter #scicomm #COVID19 #COVID19Vaccine
Thank you for this lay summary! @MPaiMD
Key takeaways 🧵⤵️ 1/ #science #MedTwitter #scicomm #COVID19 #COVID19Vaccine
▶️ Blood clots can occur 4 to 28 days post 💉 & associated w/ ⬇️ platelets
▶️ These clots...are more aggressive and are more likely to cause death or severe disability...
▶️ Rate of VITT in Canada has been estimated to be ~1/ 100k doses 2/
▶️ These clots...are more aggressive and are more likely to cause death or severe disability...
▶️ Rate of VITT in Canada has been estimated to be ~1/ 100k doses 2/
Re: contraindication: It may be possible... people with a history of HIT or CSVT w/ ⬇️ platelets are at ⬆️ risk of VITT; they should receive an mRNA vaccine (Pfizer or Moderna) rather than an adenoviral vector vaccine. 3/
⭐️ @COVIDSciOntario’s UPDATED guide to Vaccine-Induced Immune Thrombotic Thrombocytopenia #VITT Following Adenovirus Vector COVID-19 Vaccination! covid19-sciencetable.ca/sciencebrief/v…
If you’re NOT a healthcare professional, we have a lay summary for you here: covid19-sciencetable.ca/sciencebrief/v…
And targeted guides for outpatient and ED/inpatient settings are coming soon! (We’ve been working so hard on this our keyboards have caught 🔥. Need a quick breather.)
"Prioritise the elderly & high risks"
Easy to be said,
NOT easy to be done.
Many elderly people are still vaccine-hesitant:their main source of info is "fear-mongering" Whatsapp chain messages.
This is a 🧵on #COVID vaccine's risk & why we should not wait for an IDEAL vaccine.
Easy to be said,
NOT easy to be done.
Many elderly people are still vaccine-hesitant:their main source of info is "fear-mongering" Whatsapp chain messages.
This is a 🧵on #COVID vaccine's risk & why we should not wait for an IDEAL vaccine.
2/ Many of the high risk patients who we counselled for vaccine still are hesitant & adopted approach of "Tunggu Dulu la"
Despite our best efforts explaining the risks
Remember when Pfizer first came out? Many people went bonkers over the anaphylaxis issue despite reassurances.
Despite our best efforts explaining the risks
Remember when Pfizer first came out? Many people went bonkers over the anaphylaxis issue despite reassurances.
3/ When Pfizer came out, people say "oh I wanna wait for AZ/Sinovac/J&J"
Now AZ are in, people are super scared over the risk of VITT (blood clots):they are saying "Let's wait for Pfizer" 🤷🏻♀️
J&J also has reports of VITT now.
Sinovac has minimal data on adverse effects for now.
Now AZ are in, people are super scared over the risk of VITT (blood clots):they are saying "Let's wait for Pfizer" 🤷🏻♀️
J&J also has reports of VITT now.
Sinovac has minimal data on adverse effects for now.
