Thread by @ProfDFrancis

I'm so excited!

PCI proven to save lives!

And we in ORBITA have played our part!

A picture tells a thousand words. And if you use a thousand colours, it tells a million words.

Here we are! The bestest trial in all the world!

Today I am happy to say I am something to do with it!!! No longer am I saying I had nothing to do with it and it was just something @rallamee was doing without my knowledge.

@rallamee Obviously I can't take all the credit for this meta-analysis being positive.

I did have some help from my mates.

So I will share my Nobel with the SWISSI-2 boys, who had this cunning plan:

Wait for people to have an MI.
Don't PCI them.
Afterwards, look for ischaemia.
If ischaemia present, declare them to be "stable IHD" and randomize!

sci-hub.se/10.1001/jama.2…

And of course the ECSS brigade, who had the wonderful idea to do a trial without statins.

(They were helped a little, by statins not being invented yet, but still it was clever of them, so I will give them a bit of my Nobel.)

sci-hub.se/https://doi.or…

Oh dear. I am seeing David Brown's tweets now.

Hmph. Maybe I am thwarted yet again from getting my Nobel Prize.

Here is Liza Chacko and Yousif Ahmad's analysis which is a bit more careful as to what is considered "stable IHD".

ahajournals.org/doi/pdf/10.116…

In this paper we had to fight with the reviewers who said:

"No sane person says unrevascularised post MI is stable angina, so you can't say that people say that. Prove it"

We had to show them examples, and eventually settled on this wording:

Still, a 0.90 RR from ORBITA is a fine showing.

Albeit from our 0 events.

Here is the original paper, that triggered this all-too-brief moment of pride.

academic.oup.com/eurheartj/adva…

And thank you to @RicardoPetraco for whatsapping me with the news, and Burt at @angioplastyorg for the original tweet.

https://twitter.com/angioplastyorg/status/1394816160298934273