Our latest metanalysis of SARS-CoV-2T cell epitopes combines results from 25 different studies. 1400 epitopes for thus far defined from the worldwide scientific community studying CD4 and/orCD8 T cells . cell.com/cell-host-micr…
This amazing diversity is even more striking considering that the epitopes presented by many HLA alleles are relatively understated, which means the actual numbers are likely to be much higher.
The collective knowledge zeros in on immunodominant regions, that can be used to monitor responses and also as potential vaccine components
At the population level this underlines that it is unlikely the variants can escape such a large breadth of responses.
More studies are needed to assess epitopes restricted in diverse ethnicities and avoid bias towards studying relatively few more abundant HLA types. @ljiresearch @profshanecrotty @Alba_Grifoni @Dani6020
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