To maximize vaccines to halt #COVID19 - look to immunity 🧵
When someone gets their first dose - they should be offered to take a fingerprick blood sample at same time
That should be tested for SARS-CoV-2 antibodies
If positive, then don’t come back for a second dose.
1/
When someone gets their first dose - they should be offered to take a fingerprick blood sample at same time
That should be tested for SARS-CoV-2 antibodies
If positive, then don’t come back for a second dose.
1/
There is now abundant evidence that shows that people who have been infected have as good a response to their first dose vaccine as those in infected and w 2 doses.
A nice paper here discusses an approach based on knowledge of being infected in past
2/
thelancet.com/journals/ebiom…
A nice paper here discusses an approach based on knowledge of being infected in past
2/
thelancet.com/journals/ebiom…
This was a great paper in @ScienceMagazine that demonstrated strong B and T cell responses following single dose vaccine that rivaled or was even better than a two dose vaccine schedule (when absent the prior infection)
science.sciencemag.org/content/early/…
science.sciencemag.org/content/early/…
This is a terrific thread from @EricTopol discussing the strong immune responses from a single dose after prior infection With a paper from @NatureMedicine
https://twitter.com/EricTopol/status/1377610365085704196
Also - cost is not prohibitive here!
Vaccines are paid for in many countries
The cost of a blood spot, lancet and to run the Antibody test will pay for itself in the vaccine doses saved!
We perform tens of thousands of Antibody tests/wk in my lab for research for <$1 ea
Vaccines are paid for in many countries
The cost of a blood spot, lancet and to run the Antibody test will pay for itself in the vaccine doses saved!
We perform tens of thousands of Antibody tests/wk in my lab for research for <$1 ea
And here @rozeggo has already done the analysis (not yet peer reviewed).
On a quick skim it looks like exactly the types of analyses we need to be thinking of.
Important item to add - the blood drop can be done concurrent with the first dose of vaccine to increase convenience
On a quick skim it looks like exactly the types of analyses we need to be thinking of.
Important item to add - the blood drop can be done concurrent with the first dose of vaccine to increase convenience
https://twitter.com/rozeggo/status/1397577790208323588
And here is another nice thread from @swapneilparikh on this issue discussing the potential massive importance to India right now.
https://twitter.com/swapneilparikh/status/1392452889017131008
• • •
Missing some Tweet in this thread? You can try to
force a refresh
