Yes please tell me what to do with the normocalcemic hyperpara's! #aace2021#Endotwitter
In those with primary hyperparathyroidism the majority are asymptomatic. Next highest is kidney stones. It affects the radius more than fem neck more than lumbar spine #AACE2021#Endotwitter#bone
Approach to a pt with primary hyperpara who you suspect a genetic etiology #AACE2021#Endotwitter
Higher fx risk in both symptomatic and nonsymptomatic hyperparathyroidism that improves after successful parathyroidectomy #AACE2021#Endotwitter
Blue is endo/bone guideline, pink is surgery guidelines for hyperpara. Surgeons recommend considering surgery for neuropsych/cognitive sx -- strong recommendation with low-quality evidence. #Endotwitter#AACE2021
Don't restrict calcium and vit d in PHPT. Replete Vit D >20 and calcium intake should be normal #AACE2021#Endotwitter
Normocalcemic PHPT -- rule out 2ndary cause (vit d def, malabsorption, CKD, meds) #Endotwitter#AACE2021
Natural history of normocalcemic PHPT ---FU only 1-4yrs with 0-20% developing hypercalcemia #Endotwitter#AACE2021
So what do you do with normocalcemic hypoparathyroidism? Monitor and if clinically or biocehemical progression/worsening then surgery #AACE2021#Endotwitter
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I'm always amazed at the complexity that is obesity and insulin resistance. 2 types: obesity with insulin resistance and obesity w/o insulin resistance both will have mechanical abcd complications but the second will have dysglycemia & the effects from that #aace2021#endotwitter
Obesity exerts multisystemic effects and there is more to it then just weight and BMI -->thus the creation of the ABCD classification using info from EOSS staging system and other data #obesity#aace2021#endotwitter
It's always a pleasure to hear Dr. Biller speak about pituitary topics. Today is on GHD. Bottom line is that there are many barriers to dx & tx esp in those who had dx as kids and are now adults but treatment can come w/ a lot of benefit #AACE2021#Endotwitter
Here are some considerations on who to test for GHD. Highest being those w/ prior pituitary/brain surgery -- if they have 3 or more pituitary deficits then it is more likely they have GHD than not. #AACE2021#Endotwitter#ghd
Characteristics of GH stimulation tests. ITT still gold standard but not very tolerable/safe or speedy. Glucagon cheap, safe but remember the BMI cut off pts. Macimorelin very fast, easy to use and well tolerated but very expensive #AACE2021#Endotwitter#ghd
Intensive behavioral therapy by physicians can be effective helping lose >5% and even up to 10% weight loss #AACE2021#obesity
Using the term "obesity" can have a negative impact on patient care. When speaking with patients, it is better to use the terms "weight" or "BMI" or even "excess weight" #AACE2021#obesity
When to reimage a nonfunctioning pituitary incidentaloma? Risk of growth depends on size. Dr. Molitch recommends <1cm repeat MRI 1, 2, 5yrs. >1cm 0.5, 1, 2, 5yrs #ENDO2021#Endotwitter
What about symptomatic nonfunctioning pituitary adenomas? Depends on surgery outcome #ENDO2021#Endotwitter
What about Acromegaly and Cushings? Depends on treatment and post-operative cure #ENDO2021#Endotwitter