Thread by @CentreImpactAMR

Therapeutic phages can be used as treatments to kill diagnosed #AMR infections. The most valuable ones have good shelf-life properties. We found some doi.org/10.1128/mSyste… @TrevorLithgow @phagedirectory @MonashUni @GregHuntMP @AusGov_Superbug @IndustryGovAu
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We have tapped natural reservoirs with project partners, the Wurrundjeri and Woi Wurrung people (wurundjeri.com.au), the Traditional Owners of the lands on which we work doi.org/10.1128/mSyste… @phagedirectory @RhysADunstan87 @JiaweiNohup @TrevorLithgow @mSystemsJ 2/5

We needed a reliable way to characterize the structural parts of the phage particle. Our response? We built an artificial intelligence #AI to understand and characterize the new phages doi.org/10.1128/mSyste… @mSystemsJ @TrevorLithgow @RhysADunstan87 @JiaweiNohup 3/5

Does it work? Yes! It worked on Klebsiella phages MMNM and MMBB and on new phages that kill superbugs such as Enterococcus and E. coli doi.org/10.1128/mSyste… The prediction tool is called STEP3 and is freely available at step3.erc.monash.edu @MonashUni @TrevorLithgow 4/5

So what’s next? Finding more new phages useful against #AMR superbugs listed by @CDC and @WHO as causing the greatest loss of life to people around the world @MonashUni @GregHuntMP @AusGov_Superbug @TrevorLithgow @IndustryGovAu @phagedirectory doi.org/10.1128/mSyste…
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