Discover and read the best of Twitter Threads about #AMR
Most recents (24)
🧵1/Most people don’t know that everyday cuts & infections can lead to life threatening sepsis, amputation or death
New, rapid diagnostic tests are available to get the right treatment early, but docs need to start using them
insider.com/rick-bright-wa… @thisisinsider @Hilarx #AMR
New, rapid diagnostic tests are available to get the right treatment early, but docs need to start using them
insider.com/rick-bright-wa… @thisisinsider @Hilarx #AMR
2/ Failure to accurately diagnose bacteria / fungi early, often leads to delayed / wrong treatment. Every minute of delay increases severity of the infection; it’s spreading in your body
Wrong meds can make the problem worse for you & for the world, increasing drug resistance
Wrong meds can make the problem worse for you & for the world, increasing drug resistance
3/ We are losing the battle against drug resistant bacteria & fungi. Fewer drugs work on every day infections. More people are dying of sepsis. R&D funds for new drugs is shrinking.
It’s truly a silent pandemic that is closing around us.
It’s truly a silent pandemic that is closing around us.
There have been a steady stream of articles that say: 1) the plant-based meat sector is flagging; therefore 2) plant-based meat is a failed endeavor. These stories miss two critical points, a thread, 1/n:
tl/dr: 1) the theory of change has not been tried; this is like abandoning solar in 1986 or electric vehicles in 2003; 2) there is not an option that has a higher likelihood of success. If we abandon alt proteins, we will not meet climate targets (w/all that entails) + more. 2/n
FIRST: The alt proteins theory of change is that when the products compete on taste & price, they should be able to take a huge chunk of the market. But they don’t yet compete on taste and price - the current state is not future state. 3/n
1/2 This is really interesting. #Antiseptic as good as #antibiotics to prevent #urinary infection #UTI. When antibiotics came in we left earlier treatments behind, didn't compare.
2/2 Like potassium permanganate for #gonorrhoea. OK not preferred or first line, but in the age of #AMR we need to know and be ready to use if appropriate. What do science studies people make of this?
@threadreaderapp unroll
26 Finalist cohort of startups & innovators pitch to Grand Jury at CCAMP @BIRAC_2012 National Bio Entrepreneurship Competition #NBEC2022 Grand Finale!
Across
#Agri #Diagnostics #AMR #Maternal #ChildNutrition #AnimalHealth #Digitalhealth #Medtech #Therapeutics #Cleantech #WATSAN
Across
#Agri #Diagnostics #AMR #Maternal #ChildNutrition #AnimalHealth #Digitalhealth #Medtech #Therapeutics #Cleantech #WATSAN
Meet the Finalist startup & innovator cohort who pitched today at the Grand Finale of CCAMP @BIRAC_2012 #BREC National Bio Entrepreneurship Competition #NBEC2022!
NBEC, a place where #InnovationsMakeImpact
@DBTIndia @DrManishDiwan @Taslimarif @vijaychandru
NBEC, a place where #InnovationsMakeImpact
@DBTIndia @DrManishDiwan @Taslimarif @vijaychandru
Meet our remarkable jury panel comprising experts from their respective fields to review the pitches at Grand Finale of CCAMP @BIRAC_2012 #BREC #NBEC2022!
Our Jury members make NBEC what it truly is!
@DBTIndia @DrManishDiwan @Taslimarif @vijaychandru
Our Jury members make NBEC what it truly is!
@DBTIndia @DrManishDiwan @Taslimarif @vijaychandru
🧵Since the first β-lactam, aminoglycoside, macrolide, tetracycline, and fluoroquinolone classes of antibiotics were discovered and approved from 1940 to 1980, few #antibiotics with novel mechanisms of action have been developed
@thomasmd @akesselheim #AMR
science.org/doi/10.1126/sc…
@thomasmd @akesselheim #AMR
science.org/doi/10.1126/sc…
Phase III clinical trials of a antibiotic in a single disease indication cost about US$70 million. Funding for biotech companies—venture capital or government grants—cannot cover this for a drug that will be sold mainly in short courses
Cooper M & Shlaes D
nature.com/articles/47203…
Cooper M & Shlaes D
nature.com/articles/47203…
@BradSpellberg, who studies infectious diseases, sums up the problem: We'll pay $50,000 for a course of cancer chemotherapy that prolongs life by 3 months, but we don't want to pay more than $100 for a course of antibiotics that cures the target infection
nature.com/articles/509S4a
nature.com/articles/509S4a
This government has come up with a LOT of bad ideas in a very short span of time, but this still has to rank as one of their worst ones. #AMR
There’s an explosion of interest about #sewage in our rivers and seas, and concerns about what this means for people swimming in our rivers and seas. We’ve been working on this and the threat that antibiotic resistant bacteria #AMR poses to human health. A 🧵of key results:
1/8 Our systematic review of the risk of experiencing symptoms of infection after sea bathing in high-income countries found people who bathe in the sea are more likely to feel ill afterwards, compared to people who stay on land. tinyurl.com/mr27p6bs
2/8 Our recent epidemiological survey of English and Welsh beach goers in 2014-2015 also showed that the risk of illness (like diarrhoea and vomiting) was higher in bathers compared to non-bathers. tinyurl.com/4tzebj8s
We know antibiotics in the #environment are a driver for #AMR
One intervention to reduce risk in this sector could be formal regulation to control #antibiotic levels in #manufacturing discharge But how viable are these measures? 🧵/1
One intervention to reduce risk in this sector could be formal regulation to control #antibiotic levels in #manufacturing discharge But how viable are these measures? 🧵/1
Antibiotic supply chains are complex & opaque🕵️ This makes it hard for #policymakers to design and implement effective supply chain regulation that reduces #AMR risk but avoids unintended consequences on medicine affordability and availability /2
A new @Wellcome_AMR report attempts to address these ongoing questions through:
- mapping of antibiotic supply chains 🗺️
- analysing likely supply chain & economic impact of regulatory options đź’ą
- recommending next steps for supply chain sensitive regulatory approaches 🤝
/3
- mapping of antibiotic supply chains 🗺️
- analysing likely supply chain & economic impact of regulatory options đź’ą
- recommending next steps for supply chain sensitive regulatory approaches 🤝
/3
1/ Strict new rules on the use of #antibiotics and other #antimicrobials in pigs, chickens and other #farm animals come into force today across the #EU. What do the changes mean - and are they good for animals and consumers? A thread//
2/ In 2019 alone 5m deaths were connected to #AntimicrobialResistance (#AMR), according to a recent @TheLancet report. The deadly, drug-resistant infections behind these deaths come about because of the over- and misuse of antimicrobials, which makes bacteria resistant to them
3/ When drug-resistant bugs develop in animals because of antibiotic overuse they can easily spread to humans - often through #food. For example, rates of drug-resistant #salmonella have risen - & infections mainly come from #chicken & other #poultry. imperial.ac.uk/news/170889/an…
#AntimicrobialResistance đź’Š is something we all need to be aware of & understand its impact on health. Overuse of #Antibiotics for illnesses that don't need it means they can become less effective over time.
Read more in our thread below 🧵
Read more in our thread below 🧵
Dr Julie Robotham, Head of #AMR Modelling and Evaluation says on #AntimicrobialResistance 👇
🌟Ready for another #TakeoverThursday? 🌟
Today we have @LilyKenchEvans who is a student in @LIMSLTU @latrobe who will be walking us through a day in the life of a Chemistry Honours student 🧪 @ltu_researchers
This post is in celebration of @nationalmoleday (23/10) 🥳
Today we have @LilyKenchEvans who is a student in @LIMSLTU @latrobe who will be walking us through a day in the life of a Chemistry Honours student 🧪 @ltu_researchers
This post is in celebration of @nationalmoleday (23/10) 🥳
As most of my day is spent in the lab, I start with desk work such as checking data, especially if an analysis has run overnight.
While you prepare your food for the day (🥣), I am creating a to-do list & preparing my chemicals for the day's reactions 🧑‍🔬🔬
While you prepare your food for the day (🥣), I am creating a to-do list & preparing my chemicals for the day's reactions 🧑‍🔬🔬
As a reaction usually runs overnight, I then purify one from the previous day, as there may be a by-product I need to remove.
I can visualize what is in the reaction mixture through dots on a TLC plate, as seen below 🤠.
I can visualize what is in the reaction mixture through dots on a TLC plate, as seen below 🤠.
Not a submarine expert, but as a recently arrived Aussie in #Europe I’d like to offer some insights as someone who’s researched/taught Aus foreign & security policy re the #AUKUS deal, so here we go… 1/
There’s really no justification the French were caught unawares re the cancellation of the @navalgroup_AU contract. The writing had been on wall for some time that the deal was on rapidly melting thin ice. Anyone claiming otherwise just wasn’t paying attention. 2/
But it’s also true the Morrison Govt mishandled the r’ship in rushing to announce #AUKUS. At the very least, the trilateral presser should have been delayed until Morrison had spoken directly w @EmmanuelMacron, or conveyed the same through @FranceAustralia Ambassador. 3/
Repost of a thread highlighting some of the achievements of our international collaboration focussing on genomic surveillance of AMR. Here we detail a series of preprints, coming out soon as a special edition in a peer reviewed journal.
(original posted late Friday)
0/10
(original posted late Friday)
0/10
The @NIHRglobal @GHRUamr
focuses on sustainable Genomics for national #AMR surveillance in Colombia, India, Nigeria, and the Philippines and local / global genomic context for ongoing surveillance of major #AMR pathogens. Here we detail our work with a series of preprints (1/10)
focuses on sustainable Genomics for national #AMR surveillance in Colombia, India, Nigeria, and the Philippines and local / global genomic context for ongoing surveillance of major #AMR pathogens. Here we detail our work with a series of preprints (1/10)
Laboratory Implementation : An interactive approach to implement genomic sequencing across sites via lab assessment, assembly, optimisation, and re-assessment to deliver surveillance capacity.
@cake_ray @Geetha66538200 @anderson_ose @ghruamrcol
doi.org/10.21203/rs.3.… (2/10)
@cake_ray @Geetha66538200 @anderson_ose @ghruamrcol
doi.org/10.21203/rs.3.… (2/10)
The @NIHRglobal @GHRUamr focuses on sustainable Genomics for national #AMR surveillance in Colombia, India, Nigeria, and the Philippines and local / global genomic context for ongoing surveillance of major #AMR pathogens. Here we detail our work with a series of preprints (1/10)
Laboratory Implementation : An interactive approach to implement genomic sequencing across sites via lab assessment, assembly, optimisation, and re-assessment to deliver surveillance capacity.
@cake_ray @Geetha66538200 @anderson_ose @ghruamrcol
doi.org/10.21203/rs.3.… (2/10)
@cake_ray @Geetha66538200 @anderson_ose @ghruamrcol
doi.org/10.21203/rs.3.… (2/10)
Bioinformatics and data flow: Here we detail bottlenecks in bioinformatics deployment and routes to overcoming these by including standardised workflows across all laboratories. @Ayorinde_Afo @melissaana @varunshamanna @turrisita @MonicaAbrudan
doi.org/10.31219/osf.i… (3/10)
doi.org/10.31219/osf.i… (3/10)
#Phage are often only seen as bacterial predators, but they’re also major drivers of bacterial evolution through generalised transduction.
In this new preprint, we combine lab work & mathematical modelling to reveal the dynamics of this dual nature.
1/n
biorxiv.org/content/10.110…
In this new preprint, we combine lab work & mathematical modelling to reveal the dynamics of this dual nature.
1/n
biorxiv.org/content/10.110…
Generalised transduction happens when a replicating phage mistakenly packages non-phage DNA. The resulting transducing phage can inject this DNA in another bacteria, as shown in the Figure.
This is notably a powerful way to transfer plasmids, major vectors of #AMR genes.
2/n
This is notably a powerful way to transfer plasmids, major vectors of #AMR genes.
2/n
We co-cultured two single resistant strains of S. aureus (B_E and B_T) with 80alpha phage (P_L).
Here, horizontal gene transfer can only happen by generalised transduction, so if we detect double resistant bacteria (B_ET), we know that transduction happened.
3/n
Here, horizontal gene transfer can only happen by generalised transduction, so if we detect double resistant bacteria (B_ET), we know that transduction happened.
3/n
Our paper on co-infections, secondary infections & antimicrobial use in patients hospitalised with #COVID19 in UK during the 1st wave is out in @LancetMicrobe!
@ISARIC1 @CCPUKstudy @CVRinfo @UofGlasgow @EdinburghUni @LivUni @imperialcollege
thelancet.com/journals/lanmi…
A🧵
@ISARIC1 @CCPUKstudy @CVRinfo @UofGlasgow @EdinburghUni @LivUni @imperialcollege
thelancet.com/journals/lanmi…
A🧵
2/ Of 48,902 hospitalised Covid19 patients enrolled in CCP-UK study (6 Feb - 8 June 20):
- 8,649 (17.7%) had >=1 microbiological investigation
- 1,107 had Covid19-related bacterial infection (blood or respiratory); 70.6% (n=762) were secondary infection (>48 hrs from admission)
- 8,649 (17.7%) had >=1 microbiological investigation
- 1,107 had Covid19-related bacterial infection (blood or respiratory); 70.6% (n=762) were secondary infection (>48 hrs from admission)
3/ Most frequently identified organisms:
- Respiratory co-infection: Staph aureus & Haemophilus influenzae (differ from flu)
- Respiratory 2ry infection: Gram negative organisms & Staph aureus (similar to non-Covid HAI)
- Bloodstream co-/2ry infections: E Coli & Staph aureus
- Respiratory co-infection: Staph aureus & Haemophilus influenzae (differ from flu)
- Respiratory 2ry infection: Gram negative organisms & Staph aureus (similar to non-Covid HAI)
- Bloodstream co-/2ry infections: E Coli & Staph aureus
Therapeutic phages can be used as treatments to kill diagnosed #AMR infections. The most valuable ones have good shelf-life properties. We found some doi.org/10.1128/mSyste… @TrevorLithgow @phagedirectory @MonashUni @GregHuntMP @AusGov_Superbug @IndustryGovAu
1/5
1/5
We have tapped natural reservoirs with project partners, the Wurrundjeri and Woi Wurrung people (wurundjeri.com.au), the Traditional Owners of the lands on which we work doi.org/10.1128/mSyste… @phagedirectory @RhysADunstan87 @JiaweiNohup @TrevorLithgow @mSystemsJ 2/5
We needed a reliable way to characterize the structural parts of the phage particle. Our response? We built an artificial intelligence #AI to understand and characterize the new phages doi.org/10.1128/mSyste… @mSystemsJ @TrevorLithgow @RhysADunstan87 @JiaweiNohup 3/5
Delve into the world of bacteria with the latest paper from Manjula Reddy's lab. They show a novel enzyme that modulates the molecular linkages in bacterial cell-walls.
pnas.org/content/118/19…
@CSIR_IND @PNASNews @Raj_with_sci @pavan_kumarch
Details follow
(1/n)
pnas.org/content/118/19…
@CSIR_IND @PNASNews @Raj_with_sci @pavan_kumarch
Details follow
(1/n)
Bacteria have a protective cell-wall around them. It contains an exoskeleton of peptidoglycan. In a big family of bacteria, called the gram-negative bacteria, this is covered by another layer - the outer membrane.
(2/n)
(2/n)
In some bacteria, an abundantly found lipoprotein Lpp staples the peptidoglycan with the outer membrane. This study finds a novel hydrolytic enzyme that cleaves Lpp from the peptidoglycan.
(3/n)
(3/n)
Great that attention is remaining focused on #AMR a big problem. cidrap.umn.edu/news-perspecti… . But the relentless claims that this is primarily or largely a problem of agriculture are not evidence-based.
Some years ago @BillHanage and I and @G_RegevY and our students pointed out the absence of strong evidence (while acknowledging challenges of generating it) onlinelibrary.wiley.com/doi/10.1111/ev…
Recent excellent genomic work from Prof Sharon Peacock's group, @MarcBonten's group among others has failed to find evidence of strong links between resistance in animals and resistance in clinical isolates. @BillHanage wrote about this mbio.asm.org/content/10/2/e…
A chilling headline but realistic and honest assessment from @WHO. The only way to change this is to combine all the tools - Public Health, Diagnostics, Treatment, O2, PPE & Vaccines. But will only work if these tools are equitably available everywhere. theguardian.com/world/2021/apr…
Very small group countries can make this happen globally. Pandemic will continue if those countries who can do not share all tools. New variants will arise-it is enlightened self-interest,needs political leadership, an economic imperative as well as scientific, public health wise
History will not be kind on those who chose not to share, who created a world of have & have nots, of growing inequality - and a protracted pandemic in which new variants arise and spread. We face a choice. What sort of world do we want?
Starting another thread of excellent microbiology & microbiome events coming up! Feel free to add yours.
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@EMBARK_JPIAMR is putting on a series of webinars on antimicrobial resistance in microbiomes & the global environment. Super important topics that deserve attention even as we deal with COVID-19.
antimicrobialresistance.eu/2021/03/26/emb…
#AMR
@svetlana_up
antimicrobialresistance.eu/2021/03/26/emb…
#AMR
@svetlana_up
I'm excited about this one -- Agriculture & Health Summit: Cultivating Gut Health at the Crossroads of Food & Medicine
aghealthsummit.com
The scientific / regulatory conversation here is going to be white hot --> like, can we conceptualize something in between food & drug?
aghealthsummit.com
The scientific / regulatory conversation here is going to be white hot --> like, can we conceptualize something in between food & drug?
1. A quarter of the world’s total #SARS-Cov2 virus genomes have been sequenced on @nanopore devices. First sketched out as an idea here by David Deamer in 1989 this series of tweets covers the long history of nanopore sequencing.
2. Taking 25 years to fully materialise the development of nanopore sequencing has involved close collaboration between academia and industry and many actors from different disciplines and backgrounds. Each has their own story to tell.
whatisbiotechnology.org/index.php/scie…
whatisbiotechnology.org/index.php/scie…
3. Another early pioneer of @nanopore sequencing was #HaganBayley, a British chemist who in the 1990s began working on stochastic sensing as tool to detect metal ions to track submarines as they move through water and for other applications.
While COVID19 is grabbing world attention, another global public health threat is still rising in the wings - #AMR. By 2050 AMR could cause 10 million deaths if left unchecked. AMR is not new and its history stretches back long before penicillin. whatisbiotechnology.org/index.php/exhi… /1
The first case of drug resistance was noted in 1907 by #PaulEhrlich, when he observed mice infected with Trypanosoma brucei developed resistance with repeated doses of #Salvarsan, the first compound found to have antimicrobial activity. whatisbiotechnology.org/index.php/exhi… /2
Another drug spotted to cause resistance was Optochin, an antimicrobial agent used to treat pneumonia. The first instance of resistance was noted in mice, infected with pneumococcal bacteria, in 1910, and then in humans in 1913. /3
Sadly, the @AOMConnect #AMR editors continue the all-too-common mistake of conflating Coase and Williamson and even cite Coase as source of TCE. But they're not the same, or even commensurable, as I show in my forthcoming SMR paper (linked in next tweet). journals.aom.org/doi/10.5465/am…
Bylund (2021). "The firm vs. the market: Dehomogenizing the transaction cost theories of Coase and Williamson." Strategic Management Review Vol. 2, No. 1. leeds-faculty.colorado.edu/jere1232/smr.h…
Here's the error. The #AMR editors even note opportunism alongside the citation of Coase (1937), a concept Coase vehemently opposed. 🤦‍♂️
