1/9 What's on my mind ? That's a really good question having been removed from the FB Repatha Users Group and the Praulent Group. These guys really do not NOT want to hear what really causes Heart Disease, which is the 3 I's., Infection/Inflammation & Insulin Resistance.
2/9 What happens is they all gang together, insult you and sting you like a bee, because what drives them is FEAR. They are so incurious of what really causes Heart Disease. They still believe that cholesterol clogs arteries. I can't help them any more.
3/9 People like this just have to learn the hard way. I'm not sure what it would take to turn this ship around, but I don't have the energy to argue with them. When you have researched Statin drugs for over 13 years, and know precisely how they work, and how they cause
4/9 the damage they do, and when you have looked at PCSK9 inhibitors and realise that they also cause auto-immune disease, infections and worst case cancer. When you know that the PCSK9 gene is responsible for controlling Blood pressure, and you see group members
5/9 suffering either high or low BP. Where do you go ? How do you convince them ? I've given up. Please, please don't be as incurious as these people. They will have to learn the HARD way about lowering cholesterol, and the chances are the damage they have done
6/9 will be irreversible. Please please listen and look at INDEPENDENT research to learn the truth. Don't be a Statin/Repatha/Praulent VICTIM !
7/9 Now here's the magic for me: Comments like this from someone I have a lot of respect for: "Marion You work wasn't wasted on me. Keep on hammering away. Those that won't make the effort to follow the links and try to understand what the researchers have found will
8/9 Inevitably suffer the consequences. Why waste time trying to lower your cholesterol score when lowering your HbA1c is going to reduce your risk easily and cheaply.
Glycosylated hemoglobin levels can easily be reduced through lifestyle changes, the test should be at the front
9/9 line of risk reduction strategies. It's going to take some time to re-educate doctors but having only a weak indicator like cholesterol levels is pointless when getting HbA1c lower is bound to have a greater effect" Thanks Edward Hutchinson !

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More from @holmanm

26 May
1/6 What’s really going on when you take a Statin drug ? Do any of you who take them really know or even care ? Have you ever questioned it ? Statin drugs effectively reduce plasma cholesterol levels, by inhibiting the chemical transformation HMG-CoA to Mevalonate, which is an
2/6 early and rate-limiting step in the biosynthesis of cholesterol. The Mevalonate pathway is blocked which induces cells to increase LDL receptors. Increased LDL receptors forces more cholesterol into cells (bear in mind that excess cholesterol in cells is TOXIC)
3/6 However, no worry. Serum cholesterol is lowered. Take Statins, choke off the life cycle of liver cells into mass producing cholesterol receptors that soak up the supposedly 'BAD' blood cholesterol, most of which is normally made by the liver via the Mevalonate pathway
Read 6 tweets
24 May
1/6 "This is the latest hype everyone is so eager to debunk but actually the obesity insulin model hasn't been debunked it's just become more nuanced.
Here's what we know for sure. Wherever you find obesity you find high carbohydrate consumption. Every single time.
2/6 You find high insulin. You find high blood glucose.
So carbohydrates themselves do not cause obesity but you will not find obesity without carbohydrates.
And if you throw in low protein you really up the possibilities of metabolic dysfunction.
3/6 and if you throw high fat on top of the high carb, then you're really off to the races and your fatty liver disease and insulin resistance will start accelerating. Especially if that fat is not natural saturated fat but instead soybean oil or some kind of seed oil/trans fat
Read 6 tweets
24 May
1/4 The Guideline Development Group advise that there is no evidence of benefit from adding supplements of CoQ10 to reduce muscle related adverse events. They ignored the fact that Statins block the endogenous production of CoQ10. Tiredness, or muscle pain,
2/4 become an inevitable side effect for many people due to this fundamental interference with mitochondrial energy production.
CoQ10 is the most important acceptor and donor of electrons in the Krebs citric acid cycle (oxidative phosphorylation).
3/4 Biochemist Dr John McLaren-Howard’s ATP profile test measures the rate of oxidative phosphorylation which controls the rate of ADP (adenosine diphosphate) to ATP (adenosine triphosphate) conversion. His clinical co-author, Dr Sarah Myhill, writes that Statins invariably
Read 4 tweets
24 May
1/5 Statins and other cholesterol lowering meds undoubtedly have pleiotropic effects that may largely account for the minuscule clinical benefits observed. However you have to balance those against the very unfavourable consequences of taking this type of drug.
2/5 It is my opinion that the epidemic of heart failure and atherosclerosis we are seeing right now is aggravated by the pervasive use of cholesterol lowering drugs. In the case of statins they inhibit the synthesis of vitamin K2, the cofactor for matrix Gla-protein activation,
3/5 which in turn protects arteries from calcification. Statins also inhibit the biosynthesis of selenium containing proteins, one of which is glutathione peroxidase serving to suppress peroxidative stress. Statin treatment also leads to decreased insulin secretion in the
Read 5 tweets
5 May
1/6 I visit FB forums to see what's going on: Read this and do some SERIOUS thinking.

Sleepless night: I, with HIGH cholesterol (notably LDL), and NOT on a Statin - just passed a Coronary calcium score with a flying colors mark of ZERO.
2/6 (Yes, I know this doesn’t show soft plaque, and that I shouldn’t assume that I have dodged all bullets).
Contrast that with my husband, who is on a Statin, and has “BETTER” LDL cholesterol numbers than I do - has just had a heart attack and catheterization this late night
3/6 and more issues to address. I will find out the extent of things once I get back to the hospital in a few hours.
Just heard he has 100% blockage in the LAD and will need a bypass. WOW.
Read 6 tweets
26 Apr
1/5 It is very, very hard to explain how utterly disreputable the lipid hypothesis is. All of this angst about increased LDL-C and/or apoB counts on LC diets is based on the assumption that somewhere, somehow, cholesterol is the cause of heart disease. How LDL-C invades"
2/5 (by active and controlled transcytosis!) the sub-endothelial space, disappears from there and then suddenly appears at over 200 micrometres deeper, with none showing in the intervening zone requires a belief tenet which bears no resemblance to reality...
3/5 No one would reasonably doubt that the lipid deep down at the intima/media junction level comes from lipoproteins (though there are other plausible explanations). No one would doubt that loading the lipoproteins with with Linoleic acid is likely to be a Bad thing.
Read 5 tweets

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