If you want to consider the travesty of medical advice vs evidence during COVID-19, vitamin D is an amazing example

100s of millions of people have self-medicated/been treated with vit D for COVID. The evidence base is trash
A living Cochrane systematic review last updated May 2021 gives you an idea of this - as of 14 months into the global pandemic, there are 3 published RCTs on vitamin D

<400 total patients

cochranelibrary.com/cdsr/doi/10.10…
And look, it's never been tremendously likely that vitamin D was the key ingredient to banishing COVID-19, but it is wild that so many people have taken it for the disease and we still don't even know if there are harms to that or not
Also worth noting that, despite there being basically no good evidence about vitamin D/COVID-19, there are somehow nearly 1,000 PUBLISHED PAPERS on the topic which begs the question of what the point of academia is in the first place
Anyway, I'm still skeptical about vitamin D but the point here is that if someone asks you "can vitamin D help with COVID-19" the only correct answer is a GIANT SHRUG and that is a heinous situation at this point in the pandemic

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More from @GidMK

2 Jun
This is one of my favourite things of the year

People on Tiktok are drinking lettuce water because of a rumour it helps you sleep

This is all apparently based on a 2013 study that looked at lettuce leaf/seed extracts IN MICE @justsaysinmice Image
Now, I should say that the original rumour that started on Tiktok may not be entirely due to this study. The Pedestrian article says that this is the research backing up the claim, but there's no evidence that's true Image
Nevertheless, this study is BRILLIANT:

- extracted substances from lettuce leaf/seeds
- gave extract to mice
- sedated mice
- measured sleep times (slight difference)
Read 8 tweets
30 May
A "new study" has hit the headlines that apparently proves that SARS-CoV-2 was lab-grown

I am QUITE SKEPTICAL for a number of reasons, would love your thoughts...
First massive red flag🚩: the paper is NOT PUBLISHED YET

Science journalists know you NEVER report on a paper that is unpublished (because it might be shit)
Second 🚩🚩🚩: the abstract is...kind of weird

I'm not a virologist, but talking about some previous experiments that "reverse the burden of proof" is...not really logical
Read 7 tweets
27 May
An interesting new study - systematic review and meta-analysis for ivermectin. Found:

- no benefit for all-cause mortality
- no benefit for length of stay

Both very low-quality evidence
medrxiv.org/content/10.110…
I haven't had time to read it in extreme detail yet, but a quick skim seems to show that it is a fairly good piece of research that the authors have already improved in the 24 hours since it went online
Arguably the most important point of the study - the vast majority of evidence on ivermectin for COVID-19 appears to be of extremely poor quality even when you limit the results only to the best studies
Read 5 tweets
27 May
This is a bizarre take. The evidence has stayed precisely the same - natural origin very likely, lab leak thus far entirely unproven and a very low chance

The rest is mostly misconceptions caused by reading only sensationalist headlines
There is an excellent and comprehensive thread on the issue here, but the basic point is that experts pretty much universally agree that a natural origin is by far the most likely explanation
It is POSSIBLE that there was a lab leak and THIS SHOULD BE INVESTIGATED, but it is also only a very SMALL possibility and certainly not more likely than a natural explanation
Read 7 tweets
26 May
People* who are short-sighted sleep WORSE** than those with normal vision***, study finds****

*University students
**Have slightly different markers of melatonin
***p=0.04
****n=32

🙄🙄🙄🙄
The study is here, and I mean...sure? Look at a few uni students, see if the melatonin is different between them

pubmed.ncbi.nlm.nih.gov/33030546/
It's just not really much of a finding, and it's definitely not enough to even demonstrate that there is a solid difference between people with and without myopia
Read 4 tweets
24 May
Stumbled on this paper about a retracted vitamin D study last year, and it is a WILD RIDE

This paper got 100,000s of downloads on SSRN, and changed worldwide policy

It also might have been...entirely fraudulent?

ncbi.nlm.nih.gov/pmc/articles/P…
You might not remember the paper, but it was a HUGE DEAL back in mid-2020

It claimed that survival of patients in Indonesia was essentially entirely dependent on vitamin D levels
It was also removed (without any notes) from SSRN sometime in June 2020. Disappeared without a trace

Read 8 tweets

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