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Luca Arcari Profile picture
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12 Jun, 6 tweets, 4 min read
Finally published on @journalofCMR!!! Cardiac biomarkers and #WhyCMR T1 and T2 mapping in people with chronic kidney disease - Thanks to @GoetheCVI @v_puntmann @c_eike jcmr-online.biomedcentral.com/articles/10.11… Few considerations below.
We found independent associations between increasing natriuretic peptide/hsTropT on one side and myocardial involvement as assessed by native T1 and T2 mapping on the other ➡️ cardiac biomarkers=cardiac involvement (not only reduced elimination). (1/3)
Is cardiac involvement characterized by diffuse fibrosis only? Likely not: increased T2=contribution of myocardial edema. ❗️❗️T2 decreases after hemodialysis, proportionally to revomed volume❗️❗️ (2/3)
Considering water-sensitiveness of current T1 mapping sequences, this would make volume overload a significant factor when interpreting both myocardial native T1 and T2 findings (as previously suggested here nature.com/articles/s4159… and here nature.com/articles/s4159…) (3/3)
@williammoody @dr_tkot @RenalRutherford @DrMattGB @kenneth_mangion @JMascherbauer @dr_m_fontana
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More from @Luca_Arcari88

Luca Arcari Profile picture
28 Sep 20
Just published our latest work.

Investigating myocardial involvement in #COVID19 by troponin and BNP: dual center study on the first wave in Lazio region, Italy. link.springer.com/article/10.100… @mikeolangel @beamusumeci1 @P_Martelletti. Here it follows some considerations.
1. Increase of troponin/BNP was common in our sample, higher in patients with worse in-hospital prognosis (consistently shown in literature). Take into account epidemiological characteristics of the population: older age, high rate of comorbidity and fatal outcome.
2. Troponin and BNP generally had parallel increase, both in relation to A) markers of disease severity (D-dimer, CRP, P/F) and B) pre-existing condition of vulnerability (age, previous CVD, renal insufficiency etc.). However,
Read 7 tweets
Luca Arcari Profile picture
15 Aug 20
Just published on @SciReports: disq.us/t/3qzu3fo,
Role of dyspnea at presentation in #Takotsubo. Thanks to
@FraSantoroMD @beamusumeci1 @lucarlimite @IngoEitel. Here it follows some considerations.
1- Dyspnea was associated with both worse in-hospital and long-term outcome. Similarly described in AMI (ref #12 and #13) in which heart failure symptoms at presentation might reflect wider myocardial damage. Why is it so even for a “transient” condition such as #Takotsubo?
2- Dyspnea was independently associated with both higher cardiac impairment and comorbidity burden, intuitively linked to the worse prognosis in the acute phase. And long-term, after recovery of cardiac function? We tried to give two possible explanations (just hypothesis).
Read 9 tweets

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