Frequency of alcohol consumption has as much of an impact on glutamate production as amount
Consuming 2-3 drinks every couple days will cause milder but more prolonged glutamate upregulation, while binging 10+ drinks once a month will cause severe but short term glutamate spikes
Consuming 2-3 drinks every couple days will cause milder but more prolonged glutamate upregulation, while binging 10+ drinks once a month will cause severe but short term glutamate spikes
This is the main driver of alcohol tolerance over time
Since alcohol potently suppresses glutamate signalling (mimicking GABA), the brain over compensates with increased glutamate production
This is also what makes alcohol withdrawal directly neurotoxic with a seizure component
Since alcohol potently suppresses glutamate signalling (mimicking GABA), the brain over compensates with increased glutamate production
This is also what makes alcohol withdrawal directly neurotoxic with a seizure component
If you have an alcohol tolerance your glutamate production is at a higher than normal baseline
This often has a powerful negative impact on mental health, especially anxiety and depression
Alcohol consumption feels better short term, but accumulates toxicity over time
This often has a powerful negative impact on mental health, especially anxiety and depression
Alcohol consumption feels better short term, but accumulates toxicity over time
People will often justify consumption with the idea that consuming small amounts of alcohol have a hormetic effect
Even if this is the case (I'm skeptical), it's a trade off between quality of mental health and longevity, and it's likely confounded by healthy personality traits
Even if this is the case (I'm skeptical), it's a trade off between quality of mental health and longevity, and it's likely confounded by healthy personality traits
Besides that, the "optimal" alcohol consumption shown in these studies ends up only averaging out to half a drink per day
I don't know anyone that actually consumes this amount for longevity purposes, most actually end up using 1-2 drinks daily
I don't know anyone that actually consumes this amount for longevity purposes, most actually end up using 1-2 drinks daily
If you're going to drink the best consumption split seems to be 1-2 drinks every 1-3 months
This amount will still crash sleep for a day or two, but as a general rule of thumb as long as you don't develop a tolerance to its effects these changes are not long term
This amount will still crash sleep for a day or two, but as a general rule of thumb as long as you don't develop a tolerance to its effects these changes are not long term
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