Using olive oil or canola oil - a "less bad" seed oil - instead of soybean oil for cooking led to large reductions in insulin resistance and fatty liver in men with fatty liver disease.

Best results with olive oil.

liebertpub.com/doi/abs/10.108…
Soybean oil contains large amounts of omega-6 linoleic acid, canola less, with olive oil the least.
Striking evidence that seed oils, aka vegetable oils, are bad news and may play a huge role in the epidemic of fatty liver, metabolic syndrome, and ultimately, diabetes.
Corn oil induces insulin resistance and reduces physical activity in mice.

Widespread use of seed oils could be doing the same thing in humans.

Insulin resistant? Don't feel like moving or exercising?

Ditch seed oils.

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More from @Mangan150

28 Jun
South Asians suffer from metabolic syndrome and diabetes at a lower body mass index than others.

Much energy has been expended on finding out why, but the most obvious explanation is being skinny fat, i.e. high body fat and low muscle mass.
Case in pint:

"South Asians compared with Europeans had a higher mean per cent body fat (26.8 % vs 22.5 %, p = 0.05)" - at the same BMI.

link.springer.com/article/10.100…
Low protein consumption due to low intake of animal foods and a high rate of vegetarianism, and a high consumption of refined grains, sugar, and seed oils promote being skinny fat.
Read 5 tweets
27 Jun
The combination of high carb + high fat diet may be necessary for obesity.

The combination of high carb + high polyunsaturated fat (seed oils) may be necessary for diabesity.

That's what the evidence looks like to me.
Low protein an additional factor.
There's a food out there that has zero carbs, low polyunsaturated fat, and is high protein to boot.

It's called meat.

Among the healthiest foods you can eat.
Read 7 tweets
27 Jun
Aspirin use has been associated with large reductions in heart disease and cancer.

Obviously, our ancestors did not use aspirin yet didn't have a lot of heart disease or cancer.

So, what in modern life does aspirin protect against? sciencedirect.com/science/articl…
Aspirin inhibits COX-1, an enzyme which synthesizes prostaglandins from arachidonic acid.

Prostaglandins are involved in inflammation, pain, and platelet aggregation, and this is how aspirin decreases them.

onlinelibrary.wiley.com/doi/abs/10.100…
Arachidonic acid, the source material for prostaglandins, is much higher when large amounts of omega-6 linoleic acid is consumed.

Arachidonic acid levels vary widely in humans depending on diet. High consumption of seed oils increases it.
Read 4 tweets
26 Jun
Endocannabinoids are several fold higher in obese vs normal weight people.

Why does this matter?

Thread 👇

journals.plos.org/plosone/articl…
Higher endocannabinoids could be very important in the development of obesity.

Overactivation of endocannabinoids could lead to ectopic fat, in turn leading to insulin resistance.

journals.physiology.org/doi/full/10.11…
One cause of increased endocannabinoids: high intake of omega-6 fatty acids.

Main dietary source: seed oils.

pubmed.ncbi.nlm.nih.gov/20013888/
Read 9 tweets
18 Jun
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, muscle strength, and cognition

👇

onlinelibrary.wiley.com/doi/full/10.10…
For those of you who don't know, NAC and glycine are cheap OTC supplements.

NAC is a delivery vehicle for the sulfur amino acid cysteine, which oxidizes readily but does not when formulated as NAC. Cells take up NAC and convert it into cysteine.

Glycine is itself an amino acid
The results of this study show that the combination of NAC and glycine in people age 71-80 fights aging, and the results are not weak.

Since the supplements used are amino acids, that means that someone eating a higher protein diet might get similar results.
Read 7 tweets
17 Jun
Anti-obesity drugs are of obvious interest to drug companies - virtually unlimited market, and people would likely have to take these drugs for life.

Many such drugs not only show weak results, but have serious side effects. Several have been withdrawn. link.springer.com/article/10.100…
A combination of 2 drugs and an amino acid appears to be safe. Participants lost ~5 lbs. (2.4 kg) in 16 weeks without any dietary/exercise change.

The result is remarkable yet also weak.
journals.lww.com/americantherap…
Unless some drug shows up that has better results, any drug will have to be combined with diet and/or exercise to have any significant effect on obesity.

But then we've come full circle: diet is the most effective anti-obesity intervention.
Read 6 tweets

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