Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, muscle strength, and cognition

👇

onlinelibrary.wiley.com/doi/full/10.10…
For those of you who don't know, NAC and glycine are cheap OTC supplements.

NAC is a delivery vehicle for the sulfur amino acid cysteine, which oxidizes readily but does not when formulated as NAC. Cells take up NAC and convert it into cysteine.

Glycine is itself an amino acid
The results of this study show that the combination of NAC and glycine in people age 71-80 fights aging, and the results are not weak.

Since the supplements used are amino acids, that means that someone eating a higher protein diet might get similar results.
However, protein consumption among older adults is shockingly low, and the RDA for protein from health authorities is inadequate, many scientists contend.

Of course, the taboo on eating more meat doesn't help.
Even if NAC and glycine are a band-aid for low protein consumption, they can obviously help. When it comes to fighting aging, you can't wait for 100% certainty, otherwise you'll die first.

But, the FDA is trying to ban NAC.
The FDA has been trying to ban supplements for decades, but has been largely stopped by legislation.

Trying to ban NAC seems particularly insidious.

NAC may well be effective as a Covid/flu treatment.

Is that why they're trying to ban it?
In any case, NAC + glycine may increase healthspan for the elderly, conceivably even increase lifespan.

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More from @Mangan150

17 Jun
Anti-obesity drugs are of obvious interest to drug companies - virtually unlimited market, and people would likely have to take these drugs for life.

Many such drugs not only show weak results, but have serious side effects. Several have been withdrawn. link.springer.com/article/10.100…
A combination of 2 drugs and an amino acid appears to be safe. Participants lost ~5 lbs. (2.4 kg) in 16 weeks without any dietary/exercise change.

The result is remarkable yet also weak.
journals.lww.com/americantherap…
Unless some drug shows up that has better results, any drug will have to be combined with diet and/or exercise to have any significant effect on obesity.

But then we've come full circle: diet is the most effective anti-obesity intervention.
Read 6 tweets
11 Jun
My client Majed completely transformed his body composition in just 12 weeks: down 20 pounds and 4 inches around his waist.

Here’s his testimonial:

“I had a big belly even though I was working out 4-5 days/week

Truth is, I wasn’t sure that coaching would work
But clearly, PD’s advice was spot on

I went from 4-5 days a week training, to only 2 days a week

And I lost 4 inches off my waistline, my arms are bigger

And energy levels are fantastic"
If you want an effective, efficient and, most importantly, SUSTAINABLE strategy designed just for you

So that you can
-Lose the excess body fat once and for all
-Get all the health benefits of exercise in 40-50 minutes per week
-Have the freedom to NEVER go hungry
Read 4 tweets
10 Jun
The wrong question is “does it work”

You see, the right question about choosing a fat loss strategy is is…

Will it work for me LONG-TERM
The truth about about diets and workout routines?

Everything can work short-term

But short-term thinking won’t get you forever results
So here’s the deal

If you’re wanting to lose excess body fat…

And install a fitness system in your life that won’t require you to:

-Choose salad over steak
-Get a gym membership
Read 4 tweets
7 Jun
N-acetylcysteine is a safe, effective, and cheap OTC supplement that's been shown useful in many different health conditions.

That's why the FDA doesn't want you to have it.
Here's an example of why n-acetylcysteine irks the establishment:

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients

RCT

Authors specifically mention how cheap NAC is:
"A monthly supply of 600-mg NAC capsules... costs $15–30 on the retail market... sharply contrasts with the estimated average annual direct medical costs of ∼$22,580 per patient in 2009. Thus, the cost of NAC at $180–360/year would be negligible" compared to lupus burden.
Read 5 tweets
7 Jun
Metabolic syndrome and non-alcoholic fatty liver disease are essentially two definitions of the same problem.

You definitely want to avoid fatty liver

karger.com/Article/Abstra…
Substituting starch for sugar, at the same calorie intake, cut liver fat in half, in 9 days.

Evidence points to sugar (fructose) as causing fatty liver

sciencedirect.com/science/articl…
Higher protein diet, 30% protein, either animal or plant protein, decreased liver fat

40% carbs, lower than what most people eat but not "low carb", could also contribute to less liver fat.

sciencedirect.com/science/articl…
Read 4 tweets
31 May
VO2max, or total aerobic power, is tightly correlated to blood volume and total hemoglobin.

journals.lww.com/acsm-essr/full… Image
When untrained men trained for 6 weeks, VO2max and peak cardiac output increased, but the increase was abolished by calibrated phlebotomy to bring their blood volume back to baseline.

physoc.onlinelibrary.wiley.com/doi/full/10.11…
Why does this matter? Because continuous aerobic training is not some kind of super-special training modality.

Any exercise that causes sufficient muscular work will increase VO2max.
Read 7 tweets

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